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- A case report of successfully treated metachronous gastrointestinal stromal tumor and colon cancer
- Young Jin Heo, Ji Young Lee
- Kosin Med J. 2023;38(1):60-65. Published online March 8, 2023
- DOI: https://doi.org/10.7180/kmj.22.138
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- The diagnosis of gastrointestinal stromal tumor (GIST) has become relatively common in recent years, but little is known about its association with other malignancies. We present a rare case of successfully treated metachronous GIST and colon cancer with concurrent FOLFOX (5-fluorouracil, leucovorin, and oxaliplatin) chemotherapy and imatinib. A 63-year-old man presented with abdominal pain that had started 2 weeks ago, and endoscopic ultrasonography showed masses that were compatible with GIST on the duodenum. He underwent Whipple surgery. One year after the GIST diagnosis, two liver masses were found on abdominal computed tomography images taken for surveillance. A liver biopsy showed metastatic adenocarcinoma, not GIST. Colonoscopy was then performed to identify the primary site of the metastatic adenocarcinoma in the liver, and sigmoid colon cancer was found. He received 12 cycles of adjuvant FOLFOX concurrently with adjuvant imatinib. There were no serious adverse events of grade 3 or higher from either imatinib or chemotherapy. He has completed adjuvant imatinib and FOLFOX chemotherapy and there is no evidence of disease recurrence. When a synchronous or metachronous tumor is found in a GIST patient, the clinician should keep in mind the possibility of another primary tumor of different histopathology, as well as GIST recurrence.
- Comparison of the prevalence and histology between primary benign bladder tumors and recurrent benign lesions after transurethral resection of malignant bladder tumors
- Jae Jin Baek, Yong Deuk Seo, Dong Ha Kim, Won Tae Seo, Su Hwan Kang, Taek Sang Kim, Bong Kwon Chun
- Kosin Med J. 2023;38(1):43-49. Published online February 17, 2023
- DOI: https://doi.org/10.7180/kmj.22.133
- 942 View
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- Background
Benign bladder tumors are rare disease entities, and insufficient studies have assessed their epidemiological characteristics. The authors investigated the prevalence of benign bladder tumors by retrospectively investigating pathology reports of transurethral resection of bladder tumor (TURBT) procedures over the past 20 years.
Methods
We analyzed 1,674 pathology reports of TURBT conducted in 1,160 patients from January 1, 2000, to April 30, 2022. The prevalence of benign tumors and histological classification according to the presence of primary (group 1) and recurrent (group 2) bladder lesions were retrospectively investigated.
Results
The mean age of patients was 65.2±11.5 years, and 1,284 cases (79.1%) were in men. Benign bladder tumors comprised 278 cases (248 patients) accounting for about 17.1% of the total TURBT cases (278/1,624). Furthermore, 184 patients (16.0%, 184/1,147) belonged to group 1 and 78 patients (27.4%, 78/285) belonged to group 2. Among all benign lesions that underwent TURBT, cystitis was the most common (41.0%, 114/278), and this rate was higher in group 2 (64/184 [34.8%] vs. 50/94 [53.2%], p<0.001). The prevalence of non-neoplastic lesions was higher in group 1 (44/184 [23.9] vs. 11/94 [11.7%], p<0.001). There was no difference in the prevalence of noninvasive urothelial neoplasms between the two groups (22/184 [12.0%] vs. 8/94 [8.5%], p=0.86).
Conclusions
The probability of benign lesions in TURBT was 17.1%, among which cystitis was the most common. When TURBT was performed for recurrent lesions, the frequency of benign tumors was higher than that of primary benign bladder tumors.
- Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma Arising from the Tongue: case report
- Young Chul Kim, Somi Ryu, Seong Jun Won, Jung Je Park
- Kosin Med J. 2020;35(1):58-63. Published online June 30, 2020
- DOI: https://doi.org/10.7180/kmj.2020.35.1.58
- 1,214 View
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Liposarcomas are common mesenchymal malignant tumors arising from adipose tissue. Although liposarcomas are the most frequent type of soft tissue sarcomas, accounting for approximately 20% of all soft tissue sarcomas, they are rare in the head and neck, particularly in the oral cavity. Oral liposarcomas have been reported to occur mainly on the buccal mucosa, with other sites including the floor of the mouth, tongue, palate, and mandible. This report describes a 76-year-old male patient with an atypical lipomatous tumor/well-differentiated liposarcoma of the tongue that underwent surgical excision. This report also reviews published data on these rare tumors.
- Comparative Study of Dynamic Susceptibility Contrast Perfusion MR Images between Warthin's Tumor and Malignant Parotid Tumors
- Shin Young Park, Hak Jin Kim, Wonjae Cha
- Kosin Med J. 2019;34(1):38-46. Published online June 30, 2019
- DOI: https://doi.org/10.7180/kmj.2019.34.1.38
- 1,175 View
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- 3 Citations
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Objectives To identify diagnostically meaningful differences between Warthin's tumor and malignant masses in the parotid gland by dynamic susceptibility contrast (DSC) MR imaging.
Methods Eleven malignant parotid tumors and 9 Warthin's tumors were included. MR imaging was performed on all patients. Signal intensity time curves of tumors were obtained by DSC MR imaging and dynamic susceptibility contrast percentages (DSC%) were calculated.
Results No significant difference was observed between malignant tumors and Warthin's tumors (
P = 0.437), although DSC% values tended to be higher for Warthin's tumors.Conclusions Warthin's tumor tended to have higher DSC% values than malignant parotid tumors, but this difference was not significantly different.
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Citations
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- Diagnostic imaging of salivary gland cancers: REFCOR recommendations by the formal consensus method
A. Varoquaux, N. Fakhry, B. Baujat, B. Verillaud, F. Jegoux, B. Barry, E. Chabrillac, S. Vergez, M. Terroir-Cassou-Mounat
European Annals of Otorhinolaryngology, Head and Neck Diseases.2024; 141(1): 27. CrossRef - Imagerie diagnostique des cancers salivaires : recommandations REFCOR par consensus formalisé
A. Varoquaux, N. Fakhry, B. Baujat, B. Verillaud, F. Jegoux, B. Barry, E. Chabrillac, S. Vergez, M. Terroir-Cassou-Mounat
Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale.2024; 141(1): 25. CrossRef - Advanced magnetic resonance imaging findings in salivary gland tumors
Erkan Gökçe, Murat Beyhan
World Journal of Radiology.2022; 14(8): 256. CrossRef
- Diagnostic imaging of salivary gland cancers: REFCOR recommendations by the formal consensus method
- A Case of Long-term Survival in a Patient with Primary Primitive Neuroectodermal Tumor of the Lung
- Lae Hyung Kang, Hyeong Jin Kim, Jin Ho Jang, Jun Hyun Kim, Kyoung Un Choi, Doosoo Jeon
- Kosin Med J. 2018;33(2):263-270. Published online December 31, 2018
- DOI: https://doi.org/10.7180/kmj.2018.33.2.263
- 995 View
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Primitive neuroectodermal tumor (PNET) arising primarily in the lung is an extremely rare and aggressive malignancy with poor chances of patient survival. We present a case of long-term survival by a 29-year-old woman with PNET diagnosed after a hertological and immunohertochemical examination of a biopsy specimen obtained by performing video-assisted thoracic surgery. The patient underwent a left lower lung lobe lobectomy and 6 cycles of adjuvant chemotherapy. The patient has been free of any symptoms of the recurrence of the disease for 6 years after treatment completion.
- IgA nephropathy in a patient with ankylosing spondylitis well controlled with etanercept
- Do-Hyeong Lee, Geun-Tae Kim, Na-Kyoung Hwang, Eun-Heui Kim
- Kosin Med J. 2018;33(1):85-90. Published online June 30, 2018
- DOI: https://doi.org/10.7180/kmj.2018.33.1.85
- 1,235 View
- 5 Download
- 1 Citations
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Ankylosing spondylitis (AS) can involve the eye, gastrointestinal system, cardiopulmonary system, skin, kidneys, and spinal and peripheral joints. It is rarely accompanied by immunoglobulin A (IgA) nephropathy. Although IgA is involved in both AS and IgA nephropathy, the relationship between these diseases remains unclear. We detected hematuria and proteinuria in a 32-year-old male patient with ankylosing spondylitis that remained stable for 4 years through treatment with etanercept, a tumor necrosis factor-α (TNF-α) inhibitor, and diagnosed IgA nephropathy through a renal biopsy. IgA nephropathy seems to be less commonly associated with AS disease activity or specific treatment such as TNF-α inhibitor use.
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Citations
Citations to this article as recorded by- IgA Nephropathy—Ankylosing Spondylitis–Associated or Adalimumab-Induced?
Joana Ricardo Pires, Anabela Tavares Valadão Barcelos
JCR: Journal of Clinical Rheumatology.2021; 27(8S): S449. CrossRef
- IgA Nephropathy—Ankylosing Spondylitis–Associated or Adalimumab-Induced?
- A 14-year-old boy with endobronchial carcinoid tumor presenting with asthma
- Yunmo Gu, Youngjin Hwang, Sung Won Kim
- Kosin Med J. 2017;32(2):221-226. Published online January 19, 2017
- DOI: https://doi.org/10.7180/kmj.2017.32.2.221
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Introduction Bronchial carcinoid tumors seldom occur in children, sometimes mistaken for a minor disease and diagnosed slowly. Materials and Methods: We report on a patient who diagnose tumors slowly because confused with asthma.
Results This case describes a 14-year-old boy, presenting with asthma-like symptoms throughout 3 years. He was treated as asthma but wax and wane. Chest x-ray showed an hyperlucent left lung, so we rechecked high resolution computed tomography (HRCT) for unilateral hyperinflation diseases diagnosis. It was found 1×1㎝ nodule in left main bronchus. We did bronchoscopy and discovered a round mass in the left bronchus, 2∼3㎝ away from carina. In the biopsy, it was bronchial carcinoid tumor, so we resected tumor.
Discussion Because symptoms of bronchial carcinoid tumors are various, it can often be misdiagnosed firstly. It is confused with asthma, pneumonia and foreign body. An additional examination were necessary when respiratory symptoms persist.
- Effects of L-ascorbic acid on the production of pro-inflammatory and anti-inflammatory cytokines in C57BL/6 mouse splenocytes
- Eun Hee Kong, Sun Young Ma, Jee Yeong Jeong, Kwang Hyuk Kim
- Kosin Med J. 2015;30(1):41-49. Published online January 20, 2015
- DOI: https://doi.org/10.7180/kmj.2015.30.1.41
- 1,618 View
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- 16 Citations
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Abstract Objective The imbalance between pro-inflammatory and anti-inflammatory cytokines may underlie different pain states. Although ascorbic acid is the most important physiological antioxidant that affects host defense mechanisms and immune homeostasis, there is limited information on the effects of ascorbic acid on the production of cytokines.
Methods In this study, we investigated the in vitro effect of L-ascorbic acid (AA) on the production of pro-inflammatory and anti-inflammatory cytokines by stimulating C57BL/6 mouse splenocytes with the polyclonal activators lipopolysaccharide or concanavalin A.
Results AA significantly downregulated the expression of IL-6, IL-12, and TNF-α at 48 h and 72 h in mouse splenocytes treated with a combination of polyclonal activators and AA. AA treatment also resulted in upregulation of IL-4 and IL-10 at 72 h. These findings demonstrated that AA significantly potentiated production of anti-inflammatory cytokines whereas there was an inverse association between AA and expression of pro-inflammatory cytokines in mouse splenocytes.
Conclusion AA may have potential applications in the reduction of inflammatory pain because of its function in modulating the production of cytokines. However, further in vivo investigations are necessary to elucidate the mechanisms involved.
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Citations
Citations to this article as recorded by- Interleukin-8 and neutrophil extracellular traps in children with lupus nephritis and vitamin C deficiency
Chanunya Santiworakul, Wilasinee Saisorn, Nuanpan Siripen, Asada Leelahavanichkul, Pornpimol Rianthavorn
Pediatric Nephrology.2024; 39(4): 1135. CrossRef - Antioxidant Activity, Stability in Aqueous Medium and Molecular Docking/Dynamics Study of 6-Amino- and N-Methyl-6-amino-L-ascorbic Acid
Lara Saftić Martinović, Nada Birkic, Vedran Miletić, Roberto Antolović, Danijela Štanfel, Karlo Wittine
International Journal of Molecular Sciences.2023; 24(2): 1410. CrossRef - Anticancer Activity of Mineral-Supplemented Organically Cultivated Carrot on HT-29 Cells and Its Anti-Inflammatory Effect on Mice Splenocytes
Yanni Pan, Yeon-Jun Lee, Sin-Il Sin, Seung-Hwan Park, Kun-Young Park
Applied Sciences.2023; 13(16): 9209. CrossRef - Sitagliptin Attenuates the Cognitive Deficits in L-Methionine-Induced Vascular Dementia in Rats
Suzan A. Khodir, Manar A. Faried, Huda I. Abd-Elhafiz, Eman M. Sweed, Krzysztof Siemianowicz
BioMed Research International.2022; 2022: 1. CrossRef - Combination Treatment of Omega-3 Fatty Acids and Vitamin C Exhibited Promising Therapeutic Effect against Oxidative Impairment of the Liver in Methotrexate-Intoxicated Mice
Mohammed Alorabi, Doha Saad Mohammed, Gomaa Mostafa-Hedeab, Suzy A. El-Sherbeni, Walaa A. Negm, Ali Ismail A. Mohammed, Hayder M. Al-kuraishy, Nani Nasreldin, Saqer S. Alotaibi, Bashir Lawal, Gaber El-Saber Batiha, Carlos Adam Conte-Junior, Valeria Pasciu
BioMed Research International.2022; 2022: 1. CrossRef - STAT3 inhibition decreases ATP-induced MUC8 gene expression in human airway epithelial cells
Cheol Hong Kim, Kyoung Seob Song
Kosin Medical Journal.2022; 37(2): 134. CrossRef - Critical review on the immunomodulatory activities of carrot’s β-carotene and other bioactive compounds
Gemala Anjani, Fitriyono Ayustaningwarno, Rafika Eviana
Journal of Functional Foods.2022; 99: 105303. CrossRef - Antioxidative and Anti-Inflammatory Activity of Ascorbic Acid
Agnieszka Gęgotek, Elżbieta Skrzydlewska
Antioxidants.2022; 11(10): 1993. CrossRef - The Effect of Ascorbic Acid on Interleukin-10 and Tumor Necrosis Factor-α Cytokines in Rattus norvegicus with Endometritis
Muhammad Oky Prabudi, M. F. G. Siregar, I. P. A. Nasution, S. Ilyas
Open Access Macedonian Journal of Medical Sciences.2021; 9(A): 798. CrossRef - Effect of Ascorbic Acid on Differentiation, Secretome and Stemness of Stem Cells from Human Exfoliated Deciduous Tooth (SHEDs)
Shilpa Bhandi, Ahmed Alkahtani, Mohammed Mashyakhy, Abdulaziz S. Abumelha, Nassreen Hassan Mohammad Albar, Apathsakayan Renugalakshmi, Mazen F. Alkahtany, Ali Robaian, Asma Saleh Almeslet, Vikrant R. Patil, Saranya Varadarajan, Thodur Madapusi Balaji, Rod
Journal of Personalized Medicine.2021; 11(7): 589. CrossRef - Development of a novel in vitro insulin resistance model in primary human tenocytes for diabetic tendinopathy research
Hui Yee Tan, Sik Loo Tan, Seow Hui Teo, Margaret M. Roebuck, Simon P. Frostick, Tunku Kamarul
PeerJ.2020; 8: e8740. CrossRef Active Cousinia thomsonii Extracts Modulate Expression of Crucial Proinflammatory Mediators/Cytokines and NFκB Cascade in Lipopolysaccharide-Induced Albino Wistar Rat Model
Khalid Bashir Dar, Ishfaq Shafi Khan, Shajrul Amin, Aijaz Hassan Ganie, Aashiq Hussain Bhat, Showkat Ahmad Dar, Bilal Ahmad Reshi, Showkat Ahmad Ganie
Journal of Inflammation Research.2020; Volume 13: 829. CrossRef- The potential cytoprotective effect of Vitamin C and Vitamin E on monosodium glutamate-induced testicular toxicity in rats
Safaa Mohamed El Kotb, Dalia El-sayed El-ghazouly, Omnia Ameen
Alexandria Journal of Medicine.2020; 56(1): 134. CrossRef - Combination of ascorbic acid and calcitriol attenuates chronic asthma disease by reductions in oxidative stress and inflammation
Farzaneh Kianian, Seyed Morteza Karimian, Mehri Kadkhodaee, Nasrin Takzaree, Behjat Seifi, Soheila Adeli, Elham Harati, Hamid Reza Sadeghipour
Respiratory Physiology & Neurobiology.2019; 270: 103265. CrossRef - Evaluation of Ascorbic Acid or Curcumin Formulated in a Solid Dispersion on Salmonella Enteritidis Infection and Intestinal Integrity in Broiler Chickens
Daniel Hernandez-Patlan, Bruno Solis-Cruz, Karine P. Pontin, Juan D. Latorre, Xochitl Hernandez-Velasco, Ruben Merino-Guzman, Abraham Mendez-Albores, Billy M. Hargis, Raquel Lopez-Arellano, Guillermo Tellez-Isaias
Pathogens.2019; 8(4): 229. CrossRef - Amelioration of Escherichia coli‐induced endometritis with ascorbic acid in non‐pregnant mouse models
Enitome Evi Bafor, Ikechukwu Onwukpa, Anne Oghenekevwe Itemire, Osemelomen Omoruyi, Ejiroghene Eferoba‐Idio, Kevin Odega, Osas Jim Eghianruwa
American Journal of Reproductive Immunology.2018;[Epub] CrossRef
- Interleukin-8 and neutrophil extracellular traps in children with lupus nephritis and vitamin C deficiency
- Circulating Tumor Cells and Extracellular Nucleic Acids in Breast Cancer
- Dong Won Ryu, Chung Han Lee
- Kosin Med J. 2012;27(1):1-9. Published online June 11, 2012
- DOI: https://doi.org/10.7180/kmj.2012.27.1.1
- 967 View
- 8 Download
- 1 Citations
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Circulating tumor cells (CTCs) are defined as tumor cells circulating in the peripheral blood of patients, shed from either the primary tumor or from its metastases. The detection of circulating tumor cells (CTCs) in the peripheral blood of breast cancer patients may account for the different steps in the biologic progression of the disease. The detection of microscopic disease in patients with breast cancer is imperative to prognosis and can predict the efficacy of targeted treatments. In general, there are two main methods for their detection. These are based on cytometric and nucleic acid manipulation. Both methods generally require an enrichment step to increase sensitivity of the assay. This step is based on either detection of specific surface markers using immuno-selection and/or on morphological features, such as cell size or density. We review the methods of detecting CTCs, their prognostic implications, and opportunities to exploit the properties of CTCs to develop personalized therapy.
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Citations
Citations to this article as recorded by- Effect of Docosahexaenoic Acid (DHA) on Breast Cancer Cells
Sun-yong Hwang, Tae-Hee Kim, Hae-Hyeog Lee, Heung Yeol Kim, Juhyun Seo
Kosin Medical Journal.2015; 30(2): 103. CrossRef
- Effect of Docosahexaenoic Acid (DHA) on Breast Cancer Cells
- Chnages in Tumor Growth Factors from Lung Cancer Patient and Nude Mice Injected with Lung Cancer Cell Lines
- Sang Beum Kim, Sung Dal Park, Song Myung Kim, Bang Huh
- Kosin Med J. 2010;25(1):77-89. Published online June 30, 2010
- 290 View
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- Cerebral Anaplastic Astrocytoma Presenting with Intratumoral Bleeding and Acute Subdural Hematoma : A Case Report
- Jin Wook Kim, Yong Seok Park
- Kosin Med J. 2010;25(1):94-97. Published online June 30, 2010
- 239 View
- 0 Download
- Differential Diagnosis of Fibroadenoma and Phyllodes Tumor - Additional Histopathologic Feature besides Common Diagnostic Criteria
- Min Jung Jung
- Kosin Med J. 2009;24(2):109-118. Published online December 31, 2009
- 193 View
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- Vertebral Epidermoid Tumor Mimicking Metastatic Spinal Tumor - A Case Report-
- Jin Wook Kim, Dae Yong Kim
- Kosin Med J. 2009;24(2):215-217. Published online December 31, 2009
- 219 View
- 0 Download
- Factor of FDG-PET/CT Imaging Assessment in Hepatocellularcarcinoma(HCC)
- Dong Hoon Shin
- Kosin Med J. 2009;24(1):95-101. Published online June 30, 2009
- 240 View
- 0 Download
- Temperature Change During Hepatic Cryotherapy
- Doo Sik Kim, Soo Bong Yu
- Kosin Med J. 2008;23(4):38-41. Published online December 31, 2008
- 293 View
- 0 Download
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