The need for animal experiments |
Whether the conclusions of the research cannot be obtained without animal experiments. |
Alternatives to animal experiments |
Whether researchers strive to identify other approaches for their research that do not involve animal experiments (e.g., using invertebrate models, in vitro systems, or in silico methods) |
Enhancement of animal welfare |
Whether animal welfare and ethical treatment are appropriate in terms of animal experiments and animal management. |
The relevance of species and the number of experimental animals |
Whether the species and number of experimental animals are appropriate for the research purpose. |
Appropriate assessment and management of pain |
Whether the degree of pain and distress experienced by the experimental animals during the experiments is acceptable. |
Valid timing for humane endpoints and euthanasia |
Whether the method of euthanasia for experimental animals is appropriate and the timing of humanitarian termination is reasonable. |
The proper usage of sedatives, painkillers, and anesthesia |
Whether appropriate measures are planned to reduce pain in experimental animals during experiments. |
Compliance with regulations |
Whether the research is in compliance with the provisions of Article 24 of the Animal Protection Act (Prohibition of Animal Testing) |
Professional handling of experimental animals by well-trained researchers |
Whether experimental animal handling is conducted in an ethical manner, and whether the research staff have appropriate knowledge and training related to animal experiments. |
Other matters to be discussed |
Other matters considered necessary by the Committee for the Protection and Ethical Handling of Experimental Animals. |