Kosin Medical Journal

Review article

Fat embolism syndrome: a review in cosmetic surgery: Hongil Kim, Bommie Florence Seo, Gregory Randolph Dean Evans; Kosin Med J. 2024;39(3):169-178. Published online September 25, 2024; DOI: https://doi.org/10.7180/kmj.24.126

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The growing popularity of cosmetic procedures such as liposuction and fat grafting has been accompanied by a rise in associated side effects. Among these, fat embolism syndrome stands out as a potential complication that sometimes has critical consequences. It is important to recognize that fat embolism affects organs through distinct mechanisms from those involved with other types of embolisms. Early diagnosis is crucial. Unfortunately, no effective treatments have been established for this condition. Therefore, starting with a more detailed categorization of diagnoses, developing new treatment methods for each subtype is essential.

Citations

Citations to this article as recorded by

Safety and Efficacy of Subcutaneous Buttock Augmentation in Indian Population: A Retrospective Analysis
Rajat Gupta, Priya Bansal, Gautam Chaudhury, Nandini Singh Tanwar
Indian Journal of Plastic Surgery.2025;[Epub] CrossRef
The Relationship Between Non-Traumatic Fat Embolism and Fat Embolism Syndrome (FES) in Patients with Cancer
Beáta Ágnes Borsay, Barbara Dóra Halasi, Zoltán Hendrik, Róbert Kristóf Róbert, Katalin Károlyi, Teodóra Tóth, Péter Attila Gergely
Diseases.2025; 13(6): 174. CrossRef

Original articles

Influence of Cold Ischemia Time and Storage Period on DNA Quality and Biomarker Research in Biobanked Colorectal Cancer Tissues: Min Gyoung Pak, Mee Sook Roh; Kosin Med J. 2020;35(1):26-37. Published online June 30, 2020; DOI: https://doi.org/10.7180/kmj.2020.35.1.26

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Objectives

Biobanking plays an important role in future research. Assessment and control of the preanalytical variables of biobanked tissues are fundamentals for the optimal use of biospecimens.

Methods

Forty-five colorectal cancer (CRC) tissues stored at −80°C in Bio-Resource Bank were evaluated to define the influence of cold ischemia time (CIT) and storage period (SP) on DNA quality in biobanked tissues. Three CITs (less than 30 minutes (CIT-1), 30–45 minutes (CIT-2), and 45–60 minutes (CIT-3)) and three SPs (less than 1 year (SP-1), 2–3 years (SP-2), and 4–5 years (SP-3)) were chosen. NanoDrop spectrophotometer was used to determine the 260/280 ratio for DNA purity. DNA integrity was analyzed by a UV transilluminator following electrophoresis on 2% agarose gel. To evaluate the practical usability of DNA for biomarker research, KRAS mutation status was assessed by PCR amplification.

Results

All DNA specimens had a 260/280 ratio ranging between 1.8 and 2.0 with the exception of one specimen (CIT-2/SP-2 group). For DNA integrity, DNA appeared as a compact, high-molecular-weight band with no or scanty low-molecular-weight smears. The concordance of KRAS mutation status between paired biobanked frozen tissues and formalin-fixed paraffin-embedded tissues was 100%. DNA remained stable in CRC tissues kept at room temperature for up to 1 hour and long-term storage up to 5 years.

Conclusions

Storage conditions of our biobank are suitable for long-term (at least five years) specimen preservation with high DNA quality. These results have practical implications that could affect banking guidelines.

Citations

Citations to this article as recorded by

Tumor specimen cold ischemia time impacts molecular cancer drug target discovery
Silvia von der Heyde, Nithya Raman, Nina Gabelia, Xavier Matias-Guiu, Takayuki Yoshino, Yuichiro Tsukada, Gerry Melino, John L. Marshall, Anton Wellstein, Hartmut Juhl, Jobst Landgrebe
Cell Death & Disease.2024;[Epub] CrossRef
Advancing wide implementation of precision oncology: A liquid nitrogen‐free snap freezer preserves molecular profiles of biological samples
Hanneke van der Wijngaart, Sahil Jagga, Henk Dekker, Richard de Goeij, Sander R. Piersma, Thang V. Pham, Jaco C. Knol, Babs M. Zonderhuis, Harry J. Holland, Connie R. Jiménez, Henk M. W. Verheul, Srinivas Vanapalli, Mariette Labots
Cancer Medicine.2023; 12(9): 10979. CrossRef
Precision Medicine for Gastric Cancer: Applicability from the Perspective of Helicobacter pylori Infection
Ah Cheon Park, Sung Eun Kim
The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2023; 23(3): 231. CrossRef

Endovascular treatment of acute limb ischemia due to thrombotic occlusion of the suprainguinal artery: Byung Woo Kang, Jun Ho Bae, Deuk Young Nah, Jin Wook Chung, Byeong Joo Jo, Jun Gi Park; Kosin Med J. 2016;31(1):56-66. Published online February 4, 2016; DOI: https://doi.org/10.7180/kmj.2016.31.1.56

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Abstract PDF PubReader ePub: Abstract
Acute limb ischemia (ALI) is a serious condition requiring prompt intervention due to a sudden decrease in limb perfusion threatening limb viability. Treatment of ALI depends on the clinical status of the affected limb and patient comorbidities. Surgical therapy has been the historical standard of care for restoring limb perfusion; however, percutaneous endovascular intervention has been shown to be a promising treatment option in selected patients of ALI at high surgical risk. We report on a case of a 75-year-old man with ALI caused by thrombotic occlusion of the suprainguinal artery, successfully treated with endovascular therapy including stent insertion and thrombus aspiration and catheter-directed urokinase infusion in view of the clinical findings and imaging studies.

Review article

Tc-99m HMPAO Brain SPECT for ischemic strokes: Ha Yong Yum; The Journal of Kosin Medical College. 1991;7(1):55-74.

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