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- Locally recurrent primary adrenal leiomyosarcoma discovered incidentally 7 years after initial surgery: a case report
- Myungsoo Im, Doohwa Kim, Soree Ryang, Bo Hyun Kim
- Kosin Med J. 2026;41(1):85-90. Published online March 20, 2026
- DOI: https://doi.org/10.7180/kmj.25.129
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- Primary adrenal leiomyosarcoma (PAL) is an aggressive, rare tumor that is frequently diagnosed at an advanced stage. We report the case of a 65-year-old female patient with hypertension who presented with stabbing lower abdominal pain and unintentional weight loss. Abdominal computed tomography (CT) demonstrated a 10.4×8.2×8.1 cm heterogeneous left adrenal mass without biochemical evidence of hormonal hypersecretion. Retroperitoneal left adrenalectomy was performed without complications, and histopathological examination confirmed a moderately differentiated adrenal leiomyosarcoma. The patient was followed at the outpatient oncology clinic for 5 years with no evidence of recurrence. Seven years after the initial surgery, a newly detected left suprarenal mass was identified on imaging. Abdominal CT revealed a new, well-circumscribed 7.1×6.4×6.2 cm heterogeneous mass. Laparoscopic resection of the recurrent mass was performed. Pathological examination again revealed a moderately differentiated leiomyosarcoma with positive surgical margins but no lymphovascular invasion. Immunohistochemical staining was positive for smooth muscle actin, desmin, h-caldesmin, neuron-specific enolase, and synaptophysin, findings consistent with recurrent adrenal leiomyosarcoma. This case demonstrates that PAL can recur locally after prolonged disease-free intervals, underscoring the importance of extended surveillance, potentially beyond 10 years.
- Imaging of F-18 FDG PET/CT and follow up of bilateral invasive adrenal diffuse large B cell lymphoma mimicking adrenocortical carcinoma
- Hye Kyung Shim, So Woon Kim
- Kosin Med J. 2017;32(2):269-276. Published online December 29, 2017
- DOI: https://doi.org/10.7180/kmj.2017.32.2.269
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The incidence of malignant adrenal tumors, including primary adrenal lymphoma (PAL) and adrenocortical carcinoma (ACC), is rather low. Early differentiation between ACC and PAL is necessary because the therapeutic strategies for the two differ and the prognosis of each disease is poor. Unfortunately, there is no pathognomonic characteristic of PAL, so radiologists have difficulty in differentiating it from ACC. To our knowledge, there have been only two case reports on ACC that was evaluated and followed up using F-18 FDG PET/CT. The previously reported cases were simple, involving only the bilateral adrenal glands. Here, we report on a 52-year-old man diagnosed with PAL that radiologically mimicked ACC. He had findings of heterogeneous enhancement on CT, several adjacent lymphadenopathies with internal necrosis, and abutting hepatic and bilateral crural invasion. After pathological confirmation, we monitored his prognosis using F-18 FDG PET/CT after three cycles of rituximab-CHOP and again after six cycles of treatment.
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- Primary Diffuse Large B-Cell Lymphoma of the Adrenal Glands: a Rare Cause of Paraneoplastic Neuropathy
D. V. Shestakov, К. A. Posmetukhova, Ä. Т. Älieva
Journal of radiology and nuclear medicine.2024; 105(2): 87. CrossRef
- Primary Diffuse Large B-Cell Lymphoma of the Adrenal Glands: a Rare Cause of Paraneoplastic Neuropathy
- Testosterone - producing adrenocortical carcinoma
- Byung Ju Seong, Seong Ju Kim, Han Seok Kim, Du Yong Kim, Hyun Yul Rhew
- Kosin Med J. 2007;22(1):89-92. Published online June 30, 2007
- 768 View
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