An overview of the pathogenic mechanisms of autoimmune thyroid disorders
Article information
Kosin Med J. 2014;29(2):93-98
Publication date (electronic) : 2014 December 18
doi :
https://doi.org/10.7180/kmj.2014.29.2.93
Received 2014 July 29; 2014 July 29; Accepted 2014 August 01.
Abstract
Abstract
Objectives, recent epidemiologic studies in humans suggest an increased prevalence of thyroiditis associated with the excessive administration of iodine. More than three times of recommended daily intake of iodine was observed among people in North America. These people generally presented higher level of anti-thyroglobulin antibody, anti-thyroperoxidase antibody, serum thyroid-stimulating hormone and exacerbation of lymphocytic infiltration in thyroid, which indicated the overconsumption of iodine could induce hypothyroidism and enhance the autoimmune response. However, the precise mechanism of excessive iodine intake induced autoimmune thyroid disease remains largely unknown.
Over half a century has elapsed since the 1956 identification of thyroglobulin antibodies and the devising of the first experimental model of autoimmune thyroiditis. Since then an incredible amount of experimental work has led to an ever deeper understanding of the nature of thyroid auto-antigens, the main immune mechanisms responsible for Hashimoto's thyroiditis and graves’ disease, their genetics, and therir environmental risk factor. Yet, in the majority of genetically predisposed people the individual trigger of thyroid autoimmunity remains obscure. Similarly, effective prevention strategies still remain to be established and, hopefully, will be the target of future studies.
Keywords: Autoimmune; Pathogenic mechanism; Thyroid disorders
References
1. Giulia Cogni, vato Luca Chio. An overview of the pathogenesis of thyroid autoimmunity. Hormones 2013;1:19–29.
2. Jenkius RC, weetman AP. Disease association with autoimmune thyroid disease. Thyroid 2002;2:977–88.
3. Rosalind S, Brown . Autoimmune Thyroiditis in childhood. Jclin Res Pediatr Endocrinol 2013;5:45–9.
4. Rose NR, Bona C. Defining criteria for autoimmune disease. Immunol Today 1993;14:426–30.
5. Yoshidab A, Hisa tome I, Taniguchs , Shirayoshi Y, Yamamoto Y, Miake J, et al. Pendrin is a novel autoantigen recognized by patients with autoimmune thyroid diseases. Jclin Endocrinol Metab 2009;94:441–8.
6. Psegnas , Pirozzi G, Poccoli M, Fratir , Santoni A, Palmieri G. p38MADK activation controls are the TLR3-mediated up-regulation of cytotoxicity and cytokine production in human NK cells. Blood 2004;104:4157–64.
7. Sivori S, Falco M, DellaChiesa M, Carlomagno S, Vitale M, Moretta L, et al. CpG and double-stranded RNA trigger human NK cells by Toll-like receptors: induction of cytokine release and cytotoxicity against tumors and dendritic cells. Proc Natl Acad Sci USA 2004;101:10116–21.
8. Foley TP Jr, Abbassi V, Copeland KC, Draznin MB. Brief report; hypothyroidism caused by chronic autoimmune thyroiditis in very young infants. N Engi J Med 1994;330:466–8.
9. Gessl A, Wifing A, Agis H, Steiner G, Czernin S, Boltz-Nitulescu G, et al. Activated Naive CD4+ peripheral blood T cells in autoimmune thyroid disease. Thyroid 1995;5:117–25.
10. Wang SH, Baker JR. The role of apoptosis in thyroid autoimmunity. Tyhroid 2007;17:975–9.
11. Bottazzo GF, Pujol-Borrell R, Hanafusa T, Feldmann M. Role of aberrant HLA-DR expression and antigen presentation in induction of endocrine autoimmunuity. Lancet 1983;2:1115–9.
12. Weetman AP. Cellular immune responses in autoimmune thyroid disease. Clin Endocrinol (Oxf) 2004;61:405–13.
13. Ajjan Ram Kemp EH, Waterman EA, Watson PF, Endo T, Onaya T, Weetman AP. Detection of binding and blocking autoantibodies to the human sodium-iodide symporter in patients with autoimmune thyroid disease, J Clin Endocrinol Metab 2 0000;85:2020–7.
14. Yoshida A, Hisatome I, Taniguchi S, Shirayoshi Y, Yamamoto Y, Miake J, et al. Pendrin is a novel autoantigen recongnized by patients with autoimmune thyroid diseases. J Clin Endocrino Metab 2009;94:442–8.
Epub 2008 Dec 2.
15. Feingold SB, Smith J, Houtz J, Popov sky E, Brown RS. Prevalance and functional significance of thyrotropin receptor blocking antibodies in children and adolescents with chronic lymphocytic thyroiditis. J Clin Endocrinol Metab 2009;94:4742. Epub 2009 Oct. 2223;
16. Menconi F, Monti MC, Greenberg DA, Oashi T, Osman R, Davies TF, et al. Molecular amino acid signatures in the MHC class II peptide binding pocket predispose to autoimmune thyroiditis in humans and in mice. Proc Natl Acad Sci USA 2008;105:14034–9.
17. Yoshida A, Hisatome I, Taniguchi S, Shirayoshi Y, Yamamoto Y, Miake J, et al. Pendrin is a novel autoantigen recognized by patients with autoimmune thyroid disease. J Clin Endocrinol Metab 2009;94:442–8.
18. Vasu C, Dogan RN, Holterman MJ, Prabhakar BS. Selective induction of dendritic cells using granulocyte macrophagecolony stimulating factor, but not fmslike tyrosine kinase receptor 3-ligand, activates thyroglobulin-specific CD4+/CD25+ T cells and suppresses experimental autoimmune thyroiditis. J immunol 2003;170:5511–22.
19. Kroemer G, Hirsch F, Conzalez-Garcia A, Martinez C. Differential involvement of Thl and, Th2 cytokines in autoimmune diseases. Autoimmunity 1996;24:25–33.
20. Langrish CL, Chen Y, Blumenschein WM, Mattson J, Basham B, Sedgwick JD, et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med 2005;201:233–40.
21. Yoshimoto T, Takeda K, Tanaka T, Ohkusu K, Kashiwamura S, Okamura H, et al. IL-12 up-regulates IL-18 receptor expression on T cell, Thl cells, and B cells: synergism with IL-18 for IFN-gamma production. J Immunol 1998;161:3400–7.
22. Kong YC, Morris GP, Brown NK, Yan Y, Flynn JC, David CS. Autoimmune thyroiditis: a model uniquely suited to probe regulatory T cell fuction. J Autoimmun 2009;33:239–46.
23. Gangi E, Vasu C, Cheatem D, Pravhakar BS. IL-10-producing CD4+CD25+ regulatory T cell play a critical role in granulocyte macrophage colony-stimulating factor-induced suppression of experimental autoimmune thyroiditis. J Immunol 2005;174:7006–13.
24. Quaratino S, Badami E, Pang YY, Bartok I, Dyson J, Kioussis D, et al. Degenerate self-reactive human T cell receptor causes spontaneous autoimmune disease in mice. Nat Med 2004;10:920–6.
25. Ehlers M, Thiel A, Bernecker C, Porwol D, Papewalis C, Willenberg HS, et al. Evidence of a combined cytotoxic thyroglobulin and thyroperoxidase epitope-specific cellular immunity in Hashimoto's thyroiditis. J Clin Endocrinol Metab 2012;97:1347–54.
26. Rotondi M, Chiovato L, Tomagnani S, Serio M, Romagnani P. Role of chemokines in endocrine autoimmune diseases. Endocr Rev 2007;28:492–520.
27. Ban Y, Greenberg DA, Concepcion E, Skrabanek , Villanueva R, Tomer Y. Amino acid substitution in the thyroglobulin gene are associated with susceptibility to human and murine autoimmune thyroid disease. Proc Natl Acad Sci USA 2003;100:15119–24.
28. Rose NR, Bonita R, Burek CL. Iodine: an environmental trigger of thyroiditis. Autoimmun Rev 2002;1:97–103.
29. Brent GA. Environmental exposures and autoimmune thyroid disease. Thyroid 2010;20:755–61.
30. Tomer Y. Genetic susceptibility to autoimmune thyroid disease; past, present, and future. Thyroid 2010;20:715–25.
31. Hasham A, Tomer Y. Genetic and epigenetic mechanisms in thyroid autoimmunity. Immunol Res 2012;54:204–13.
32. Jacobson EM, Huber AK, Akeno N, Sivak M, Li CW, Concepcion E, et al. A CD40 Kozak sequence polymorphism and susceptibility to antibody-mediated autoimmune conditions: the role of CD40 tissue-specific expression. Genes Immun 2007;8:205–14.
33. Burek CL, Talor MV. Environmental triggers of autoimmune thyroiditis. J Autoimmun 2009;33:183–9.
34. Duntas LH. Environmental factors and autoimmune thyroiditis. Nat Clin Pract Endocrinol Metab 2008;4:454–60.
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