A Case of Seizure and Metabolic Acidosis Due to Renal Adjustment Dosage of Isoniazid in an Elderly Woman

Article information

Kosin Med J. 2014;29(1):63-68

Publication date (electronic) : 2014 December 17

doi : https://doi.org/10.7180/kmj.2014.29.1.63

Young Shin Shin ¹, Eun Hee Sim ¹, Chang Woo Yeo ¹, Jin Doo Kang ¹, Ji Yeon Kim^,¹, Seon Ja Park ²

¹Department of Internal Medicine, Dae-Dong Hospital, Busan, Korea

²Department of Internal Medicine, College of Medicine, Kosin University, Busan, Korea

Corresponding Author: Ji Yeon Kim, Deparment of Internal Medicine, Dae-Dong Hospital, 187 Chungyel-daero, Dongrae-gu, Busan, 607-711, Korea TEL: +82-10-9323-9669 FAX: +82-51-553-7575 E-mail: bbuss36@naver.com

Received 2013 March 07; Revised 2013 May 26; Accepted 2013 July 10.

Abstract

Isoniazid is one of the most commonly used antituberculosis drug. Acute into xication is characterized by repetitious convulsions, high anion gap metabolic a cidosis and coma. The basis of theraphy consists of parental pyridoxine admi nistration in a dose equivalent to that of isoniazid ingested. Here we present a case of seizure and metabolic acidosis due to only renal adjustment dosage of Isoniazid in an elderly woman.

Keywords: Isoniazid; Metabolic acidosis; Pyridoxine; Seizure

Fig. 1.

Non-enhanced abdominal CT scan demonstrates lytic destructive change in Thoracic vertebral body.

Fig. 2.

T2-weighted sagittal MRI of spine demonstrates destruction of T10, T 11, T12 bodies due to spinal tuberculosis and secondary to abscess formation.

Fig. 3.

Skin lesions of erythema and dry patches were observed on the buttock and abdomen.

Fig. 4.

There is no gross abnormality in T2-weighted magnetic resonance imaging of brain.

Table 1.

Serial of arterial blood gas analysis

Table 2.

Comparison of laboratory examination findings before and after administrating antituberculosis agents

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