Department of Pediatrics, Busan Medical Center, Busan, Korea
Copyright © 2020 by Korean Association of Medical Journal Editors
Articles published in Kosin Medical Journal are open-access, distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Short stature, defined as height ≦ 3 percentile; Suspicious short stature children, defined as 3 percentile < height ≦ 20 percentile
Data expressed means±standard deviation
MPH, midparental height; SDS, standard deviation score; BMI, body mass index; IGFBP3, insulin like growth factor binding protein 3
Charaoteristios | Mean values | |
---|---|---|
Male | Female | |
Total Patients (n) | 121 | 111 |
Age (yr) | 10.52 ± 2.83 | 10.20 ± 2.55 |
Bone age (yr) | 10.59 ± 2.49 | 9.74 ± 2.32 |
Bone age/Chronologioal age | 0.98 ± 0.11 | 0.91 ± 0.09 |
Midparental height (om) | 170.8 ± 4.1 | 158.5 ± 3.58 |
Midparental height SDS | −0.3 ± 0.5 | −0.3 ± 0.48 |
Height (om) | 135.0 ± 15.54 | 133.0 ± 12.79 |
Height SDS | −0.81 ± 0.5 | −0.7 ± 0.45 |
BMI (kg/m2) | 18.03 ± 3.19 | 16.84 ± 2.68 |
BMI peroentile (%) | 42.71 ± 27.68 | 33.52 ± 24.41 |
IGFBP3 (ng/ml) | 4347.26 ± 1063.8 | 4459.0 ± 975.8 |
IGFBP3 SDS | 0.41 ± 0.29 | 0.36 ± 0.26 |
Short stature | Our result | KNGC2007 | KNGC2017 |
---|---|---|---|
Year | 2014.1–2019.8 | 2017 | 2007 |
Age (yr) | 5–17 | 2–18 | 2–18 |
Location | Busan (yeon-je gu, busan-jin gu) | Whole country | Whole country |
Number/Total number | 43/582 | 68/7606 | 106/7606 |
Prevalence rate | 7.3% | 0.9% | 1.4% |
variable | Short stature children(n = 58) | Suspicious short stature children(n = 174) | P-value |
---|---|---|---|
Chronological age (yr) | 10.5 ± 3.1 | 11 ± 2.5 | 0.248 |
Bone age (yr) | 9.6 ± 2.7 | 10.38 ± 2.33 | 0.031 |
Bone age/Chronological age | 0.93 ± 0.1 | 0.95 ± 0.1 | 0.310 |
Midparnetal height (cm) | 164.6 ± 7.5 | 165.0 ± 7.2 | 0.728 |
MPH SDS | −0.42 ± 0.58 | −0.27 ± 0.46 | 0.045 |
Height (cm) | 126.8 ± 15.1 | 136.5 ± 13.2 | 0.000 |
Height SDS | −1.4 ± 0.4 | −0.6 ± 0.3 | 0.000 |
Weight (kg) | 28.4 ± 12.2 | 33.8 ± 11.6 | 0.003 |
BMI (kg/m2) | 16.9 ± 3.2 | 17.7 ± 2.9 | 0.089 |
BMI percentile | 31.9 ± 24.9 | 40.5 ± 26.8 | 0.033 |
IGFBP3 (ng/mL) | 4077.7 ± 1134 | 4508.5 ± 961.4 | 0.005 |
IGFBP3 SDS | 0.3 ± 0.3 | 0.4 ± 0.3 | 0.051 |
variable | Short stature children | P-value | Suspicious short stature children | P-value | ||
---|---|---|---|---|---|---|
low socioeconomic status group (n = 43) | Normal socioeconomic status group (n = 15) | low socioeconomic status group (n = 111) | Normal socioeconomic status group (n = 63) | |||
CA (years) | 10.6 ± 2.7 | 10.1 ± 4 | 0.704 | 10.9 ± 2.5 | 11.2 ± 2.5 | 0.361 |
BA (years) | 9.5 ± 2.5 | 9.8 ± 3.2 | 0.972 | 10.1 ± 2.3 | 10.9 ± 2.26 | 0.017 |
BA/CA | 0.9 ± 0.1 | 1 ± 0.2 | 0.084 | 0.93 ± 0.1 | 0.99 ± 0.1 | 0.001 |
MPH (cm) | 164.1 ± 7.78 | 166.13 ± 6.84 | 0.397 | 164.32 ± 7.45 | 166.28 ± 6.6 | 0.086 |
MPH SDS | −0.43 ± 0.62 | −0.38 ± 0.4 | 0.846 | −0.27 ± 0.46 | −0.26 ± 0.46 | 0.846 |
Height (cm) | 127.14 ± 13.26 | 125.85 ± 19.97 | 0.764 | 135.15 ± 12.56 | 138.8 ± 14.1 | 0.080 |
Height SDS | −1.4 ± 0.5 | −1.3 ± 0.2 | 0.633 | −0.7 ± 0.3 | −0.6 ± 0.4 | 0.080 |
Weight (kg) | 28 ± 9.6 | 29.4 ± 18.2 | 0.566 | 32.5 ± 10.6 | 36.1 ± 12.9 | 0.045 |
BMI (kg/m2) | 16.8 ± 2.7 | 17.3 ± 4.6 | 0.805 | 17.4 ± 2.8 | 18.1 ± 3.1 | 0.101 |
BMI percentile | 29.7 ± 23.9 | 38.2 ± 27.3 | 0.253 | 36.6 ± 24.2 | 47.3 ± 29.7 | 0.010 |
IGFBP3 | 4176.1 ± 1047.5 | 3795.9 ± 1352.7 | 0.307 | 4661.4 ± 914.7 | 4238.9 ± 989.4 | 0.005 |
IGFBP3 SDS | 0.3 ± 0.3 | 0.3 ± 0.4 | 0.602 | 0.5 ± 0.2 | 0.3 ± 0.3 | 0.008 |
variable | P-value | Odd ratio (95%CI) |
---|---|---|
BMI percentile | 0.005 | 0.982(0.97 – 0.995) |
IGFBP3 | 0.0002 | 1.001(1 – 1.001) |
Bone age/Chronological age | 0.001 | 0.004(< 0.001 – 0.118) |
Midparental SDS | 0.684 | 0.872(0.45 – 1.68) |
Height SDS | 0.564 | 0.768(0.314 – 1.87) |
short stature group vs. suspicious short stature group | 0.498 | 1.396(0.533 – 3.657) |
Data expressed means ± standard deviation SDS, standard deviation score; BMI, body mass index; IGFBP3, insulin like growth factor binding protein 3
KNGC, Korean National Growth Charts
Short stature, defined as height ≦ 3 percentile; Suspicious short stature children, defined as 3 percentile < height ≦ 20 percentile Data expressed means±standard deviation MPH, midparental height; SDS, standard deviation score; BMI, body mass index; IGFBP3, insulin like growth factor binding protein 3
Suspicious short stature children, defined as 3 percentile < height ≦ 20 percentile Data expressed means±standard deviation MPH, midparental height; SDS, standard deviation score; BMI, body mass index; IGFBP3, insulin like growth factor binding protein 3
BMI, body mass index: SDS, standard deviation score