Fig. 1.

The alleviating effect of intrathecal dexmedetomidine and ketorolac on mechanical allodynia in spinal nerve ligation rats. All the rats underwent SNL. Group S (n = 5) received intrathecal injection of normal saline, while groups D (n = 5) and K (n = 5) received intrathecal injection of dexmedetomidine and ketorolac, respectively. Group DK (n = 5) received simultaneous intrathecal injection of both dexmedetomidine and ketorolac. At 1, 2, and 4 hr after drug injection, on 3 consecutive days beginning on the 10th day after SNL, statistically significant increases in ipsilateral paw withdrawal thresholds were shown by groups D and K compared to group S (P< 0.05); and by Group DK compared to groups D and K (P< 0.05). ∗P< 0.05 compared to Group S, † P< 0.05 compared to Group D. ‡P< 0.05 compared to Group K.

Fig. 2.

Increases in ipsilateral paw withdrawal thresholds in spinal nerve ligation rats caused by intrathecal dexmedetomidine and ketorola. Regarding % pre-SNL in ipsilateral paw, significantly higher PWTs were shown by groups D and K compared to group S at 1, 2, and 4hr after drug injection, on 3 consecutive days beginning on the 10th day after SNL (P< 0.05); and by group DK compared to groups D and K (P< 0.05). ∗P< 0.05 compared to Group S, †P< 0.05 compared to Group D. ‡P< 0.05 compared to Group K.

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Figure & Data

References

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