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Review Article
Uterine leiomyoma research
Tae Hee Kim, Hae Hyeog Lee
Kosin Medical Journal 2015;30(1):13-22.
Published online: January 20, 2015

Department of Obstetrics and Gynecology, College of Medicine, Soonchunhyang University Bucheon Hospital Gyeonggi-do, Korea

Corresponding Author:Hae Hyeog Lee, Department of Obstetrics and Gynecology, Soonchunhyang University Bucheon Hospital 170 Jomaru-ro, Wonmi-gu, Bucheon-si, Gyunggi-do, 420-767, Korea TEL: +82-10-5273-7840 FAX: +82-2-6008-6874 E-mail:,
• Received: September 12, 2013   • Accepted: October 13, 2013

Copyright © 2015 Kosin University School of Medicine Proceedings

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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  • Uterine leiomyoma is the most common type of benign tumor in women of reproductive age. This disease is rare before menarche, and its incidence decreases after menopause. Uterine leiomyoma is known to be related to hormonal changes, but the precise underlying mechanism has yet to be determined. Although it is a benign disease, the most common form of management involves surgical intervention. Uterine leiomyoma is also related to infertility and obstetric complications. Here, we present a review of the literature regarding uterine leiomyoma and discuss management of this disease.
  • 1. Levy G, Hill MJ, Plowden TC, Catherino WH, Armstrong AY. Biomarkers in uterine leiomyoma. Fertil Steril 2013;99:1146–52.ArticlePubMed
  • 2. Parker WH. Chapter 15: Uterine fibroids. In: Berek JS, editors. Berek & Novak's gynecology. 15th ed.Philadelphia: Lippincott Williams & Wilkiins; 2012. p. 438–69.
  • 3. Brahma PK, Martel KM, Christman GM. Future directions in myoma research. Obstet Gynecol Clin North Am 2006;33:199–224.ArticlePubMed
  • 4. Nasiadek M, Kilanowicz A, Darago A, Lazarenkow A, Michalska M. The effect of cadmium on the coagulation and fibrinolytic system in women with uterine endometrial cancer and myoma. Int J Occup Med Environ Health 2003;26:291–301.Article
  • 5. Kim TH, Lee HH. How should painful cystic degeneration of myomas be managed during pregnancy? a case report and review of the literature. Iranian J Reprod Med 2011;9:243–6.
  • 6. Zivkovic ˋ N, Zivkovicˉ K, Despot A, Paic ˋ J, Zelic ˋ A. Measuring the volume of uterine fibroids using 2-and 3-dimensional ultrasound and comparison with histopathology. Acta Clin Croat 2012;51:579–89.PubMed
  • 7. Kabil KS, Temizkan O, Atis A, Gozukara I, Uludag EU, Agar S, et al. Role of endometrial power Doppler ultrasound using the international endometrial tumor analysis group classification in predicting intrauterine pathology. Arch Gynecol Obstet 2013;288:649–54.ArticlePubMed
  • 8. Kongnyuy EJ, Wiysonge CS. Interventions to reduce haemorrhage during myomectomy for fibroids. Cochrane Database Syst Rev 2011;11:CD005355.Article
  • 9. Uy K, Kim TH, Lee HH, Chung SH, Lee BI. Clinical Applications of hysteroscopic surgery in postmenopausal women. J Korean Soc Menopause 2010;16:46–51.
  • 10. Semm K. New methods of pelviscopy (gynecologic laparoscopy) for myomectomy, ovariectomy, tubectomy and adnectomy. Endoscopy 1979;11:85–93.ArticlePubMed
  • 11. Dubuisson JB, Fauconnier A, Deffarges JV, Norgaard C, Kreiker G, Chapron C. Pregnancy outcome and deliveries following laparoscopic myomectomy. Hum Reprod 2000;15:869–73.ArticlePubMed
  • 12. Lee JH, Choi JS, Jeon SW, Son CE, Lee SJ, Lee YS. Single-port laparoscopic myomectomy using transumbilical GelPort access. Eur J Obstet Gynecol Reprod Biol 2010;153:81–4.ArticlePubMed
  • 13. Pitter MC, Gargiulo AR, Bonaventura LM, Lehman JS, Srouji SS. Pregnancy outcomes following robot-assisted myomectomy. Hum Reprod 2013;28:99–108.ArticlePubMed
  • 14. Pisal P, Kim T, Lee H, Lee W, Chung S. Premature Ovarian Failure After uterine artery embolization. WebmedCentral Obstet Gynecol 2013;4(7):): WMC004231..
  • 15. Kim TH, Lee HH, Chung SH. Presenting Features of Pyometra including an increase in iatrogenic causes. J Low Genit Tract Dis 2011;15:316–7.ArticlePubMed
  • 16. Kang BM, Jeong U, Ju WD, Kwon HE, Kim SH, Chae HD, et al. Clinical effect of levonorgestrel-releasing intrauterine system (Mirena) on uterine myoma and other benign gynecologic diseases. J Korean Soc Menopause 2003;9:163–70.
  • 17. Talaulikar VS, Manyonda IT. Ulipristal acetate: a novel option for the medical management of symptomatic uterine fibroids. Adv Ther 2012;29:655–63.Article
  • 18. Di Tommaso S, Massari S, Malvasi A, Bozzetti MP, Tinelli A. Gene expression analysis reveals an angiogenic profile in uterine leiomyoma pseudocapsule. Mol Hum Reprod 2013;19:380–7.ArticlePubMed
  • 19. De Falco M, Staibano S, Mascolo M, Mignogna C, Improda L, Ciociola F, et al. Leiomyoma pseudocapsule after presurgical treatment with gonadotropin-releasing hormone agonists: Relationship between clinical features and immunohistochemical changes. Eur J Obstet Gynecol Reprod Biol 2009;144:44–7.ArticlePubMed
  • 20. Malvasi A, Cavallotti C, Nicolardi G, Pellegrino M, Dell'Edera D, Vergara D, et al. NT, NPY and PGP 9.5 presence in myomeytrium and in fibroid pseudocapsule and their possible impact on muscular physiology. Gynecol Endocrinol 2013;29:177–81.ArticlePubMed
  • 21. Wang L, Mou X, Xiao L, Tang L. T-cadherin expression in uterine leiomyoma. Arch Gynecol Obstet 2013;288:607–14.ArticlePubMed
  • 22. Tuzcu M, Sahin N, Ozercan I, Seren S, Sahin K, Kucuk O. The effects of selenium supplementation on the spontaneously occurring fibroid tumors of oviduct, 8-Hydroxy-2′-Deoxyguanosine levels, and heat shock protein 70 response in Japanese quail. Nutr Cancer 2010;62:495–500.ArticlePubMed
  • 23. Shveiky D, Shushan A, Ben Bassat H, Klein BY, Ben Meir A, Levitzky R, et al. Acetaldehyde differentially affects the growth of uterine leiomyomata and myometrial cells in tissue cultures. Fertil Steril 2009;91:575–9.ArticlePubMed
  • 24. Matsuzaki S, Canis M, Darcha C, Pouly JL, Mage G. HOXA-10 expression in the mid-secretory endometrium of infertile patients with either endometriosis, uterine fibromas or unexplained infertility. Hum Reprod 2009;24:3180–7.ArticlePubMed
  • 25. Cheng Z, Xie Y, Dai H, Hu L, Zhu Y, Gong J. Unequal tissue expression of proteins from the PA/PAI system, myoma necrosis, and uterus survival after uterine artery occlusion. Int J Gynecol Obstet 2008;102:55–9.Article
  • 26. Hsieh YY, Chang CC, Bau DT, Yeh LS, Tsai FJ, Tsai CH. X-ray repair cross-complementing group 4 (XRCC4) promoter −1394 (∗) T-related genotype, but not XRCC4 codon 247/intron 3 or xeroderma pigmentosum group D codon 312, 751/promoter −114, polymorphisms are correlated with higher susceptibility to myoma. Fertil Steril 2008;90:1417–23.PubMed
  • 27. Dingiloglu BS, Gungor T, Ozdal B, Cavkaytar S, Bilge U, Mollamahmutoglu L. Serum leptin levels in women with uterine leiomyomas. Taiwan J Obstet Gynecol 2007;46:33–7.ArticlePubMed
  • 28. Mehine M, Kaasinen E, Mäkinen N, Katainen R, Kämpjärvi K, Pitkänen E, et al. Characterization of uterine leiomyomas by whole-genome sequencing. N Engl J Med 2013;369:43–53.ArticlePubMed
  • 29. Choi TY, Ahn BM, Ju BS, Song SJ, Gim SG, Reproductive endocrinology: Overexpression of Hedgehog(Hh) signaling pathway system in leiomyoma tissue. Proceedings of the 96th Korean Society of Obstetrics and Gynecology; September 30-October 2;. Seoul: Korean Society of Obstetrics and Gynecology; 2010. p. 212.
  • 30. Lee BS, Jeong CJ, Bai SW, Park KH, Cho DJ, Lee K, et al. Oncology 2, general gynecology and pelviscopy: The effect of transforming growth factor-β1 and β3 on cell division of myometrium and uterine leiomyoma. Proceedings of the 78th Korean Society of Obstetrics and Gynecology;. Seoul: Korean Society of Obstetrics and Gynecology; 1996. p. 94.

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      Uterine leiomyoma research
      Kosin Med J. 2015;30(1):13-22.   Published online January 20, 2015
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