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Review Article
Effect of Docosahexaenoic Acid (DHA) on Breast Cancer Cells
Sun-yong Hwang1, Tae-Hee Kim2, Hae-Hyeog Lee2, Heung Yeol Kim3, Juhyun Seo4
Kosin Medical Journal 2015;30(2):103-107.
DOI: https://doi.org/10.7180/kmj.2015.30.2.103
Published online: January 20, 2015

1Department of Interdisciplinary Program in Biomedical Science, Soonchunhyang University Graduate School, Asan, Republic of Korea

2Department of Obstetrics and Gynecology, College of Medicine, Soonchunhyang University, Bucheon, Republic of Korea

3Department of Obstetrics and Gynecology, College of Medicine, Kosin University, Busan, Republic of Korea

4Department of Life Science and Biotechnology, Soonchunhyang University College of Natural Sciences, Asan, Republic of Korea

Corresponding Author: Tae-Hee Kim, MD, PhD, Department of Obstetrics and Gynecology, SoonchunhyangUniversity Bucheon Hospital, 170 Jomaru-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do, 14584, Korea TEL: +82-32-621-5380, Fax: +82-2-6008-6874 E-mail: heeobgy@schmc.ac.kr; heeobgy@naver.com
• Received: September 15, 2015   • Accepted: September 16, 2015

Copyright © 2015 Kosin University School of Medicine Proceedings

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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  • Today, many materials as drug are developed having various prominent function in order to treatment of disease or cancer. Among these materials, especially docosahexaenoic acid (DHA), main constituents of omega-3 fatty acid, has a lot of beneficial and natural effects, so it has been known as anticancer material especially breast cancer. Breast cancer is disease taking high occurrence level among feminine diseases. DHA has anticancer effects on breast cancer cell, representatively inducing apoptosis, inhibiting proliferation or metastasis. Main effect of DHA on breast cancer cell is apoptosis inducing, which has mechanism that treated DHA causes lipid peroxidation increasing reactive oxygen species (ROS) level and it activates caspase 8 and caspase 9 so activated caspase occurs apoptosis. Cell lines of breast cancer are MDA-MB-231, MCF-7, SK-BR-3, T47D and ZR75. Especially this article uses the MCF-7 cell line at experiment of anti-proliferation by DHA, the MDA-MB-231 cell line at experiment of anti-metastasis by DHA, because that cell line has specialized metastasis activity. Therefore, this paper discusses the effects of natural material DHA as drug of breast cancer.
  • 1. Sun SN, Jia WD, Chen H, Ma JL, Ge YS, Yu JH, et al. Docosahexaenoic acid (DHA) induces apoptosis in human hepatocellular carcinoma cells. Int J Clin Exp Pathol 2013;6:281–9.PubMedPMC
  • 2. Kim TH, Byun DW, Park Y. Omega-3 and menopause. J Korean Soc Menopause 2012;18:75–80.Article
  • 3. Lee HH, Kim TH, Park J, Lee A, Park Y, Byun DW, et al. Expression of ezrin in vagina cells of postmenopausal rats after dietary administration of omega-3 fatty acid formula. J Menopausal Med 2014;20:97–103.ArticlePubMedPMC
  • 4. Xiong A, Yu W, Tiwary R, Sanders BG, Kline K. Distinct roles of different forms of vitamin E in DHA-induced apoptosis in triple-negative breast cancer cells. Mol Nutr Food Res 2012;56:923–34.ArticlePubMed
  • 5. Nauroth JM, Liu YC, Van Elswyk M, Bell R, Hall EB, Chang G, et al. Docosahexaenoic acid (DHA) and docosapentaenoic acid (DPAn-6) algal oils reduce inflammatory mediators in human peripheral mononuclear cells in vitro and paw edema in vivo. Lipids 2010;45:375–84.ArticlePubMed
  • 6. Zhang G, Panigrahy D, Mahakian LM, Yang J, Liu JY, Stephen Lee KS, et al. Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis. Proc Natl Acad Sci U S A 2013;110:6530–5.ArticlePubMedPMC
  • 7. Merendino N, Costantini L, Manzi L, Molinari R, Velotti F. Dietary ω −3 polyunsaturated fatty acid DHA: a potential adjuvant in the treatment of cancer. Biomed Res Int 2013;2013:310186.ArticlePubMedPMCPDF
  • 8. Wang F, Bhat K, Doucette M, Zhou S, Gu Y, Law B, et al. Docosahexaenoic acid (DHA) sensitizes brain tumor cells to etoposide-induced apoptosis. Curr Mol Med 2011;11:503–11.ArticlePubMedPMC
  • 9. Rahman MM, Veigas JM, Williams PJ, Fernandes G. DHA is a more potent inhibitor of breast cancer metastasis to bone and related osteolysis than EPA. Breast Cancer Res Treat 2013;141:341–52.ArticlePubMed
  • 10. Hwang SY, Kim TH, Lee HH. Neutral sphingomyelinase and breast cancer research. J Menopausal Med 2015;21:24–7.ArticlePubMedPMC
  • 11. Ryu DW, Lee CH. Outcome of ductal carcinoma in situ in patients with or without p53 mutations. Kosin Med J 2012;27:119–25.Article
  • 12. Choi WS, Ryu DW, Lee CH. Clinical Usefulness of Cytokeratin 5/6 as an immunohistochemical marker to predict prognosis in triple-negative breast cancer. Kosin Med J 2010;2:20–5.
  • 13. Ryu DW, Lee CH. Circulating tumor cells and extracellular nucleic acids in breast cancer. Kosin Med J 2012;27:1–9.Article
  • 14. Kim YS, Jae EA, Ryu DW, Lee CH. Peritoneal and gastric metastasis from invasive lobular breast carcinoma: a case report. Kosin Med J 2015;30:87–92.Article
  • 15. Wang X, Huang M, Wang Y. The effect of insulin, TNF alpha and DHA on the proliferation, differentiation and lipolysis of pre adipocytes isolated from large yellow croaker PloS One 2012;7:e48069.
  • 16. Schley PD, Jijon HB, Robinson LE, Field CJ. Mechanisms of omega-3 fatty acid-induced growth inhibition in MDA-MB-231 human breast cancer cells. Breast Cancer Res Treat 2005;92:187–95.ArticlePubMed
  • 17. Mandal CC, Ghosh-Choudhury T, Yoneda T, Choudhury GG, Ghosh-Choudhury N. Fish oil prevents breast cancer cell metastasis to bone. Biochem Biophys Res Commun 2010;402:602–7.ArticlePubMedPMC
  • 18. Kang KS, Wang P, Yamabe N, Fukui M, Zhu BT. Docosahexaenoic acid induces apoptosis in MCF-7 cells in vitro and in vivo via reactive oxygen species formation and caspase 8 activation. PLoS One 2010;5:e10296.ArticlePubMedPMC
  • 19. Fasano E, Serini S, Piccioni E, Toesca A, Monego G, Cittadini AR, et al. DHA induces apoptosis by altering the expression and cellular location of GRP78 in colon cancer cell lines. Biochim Biophys Acta 2012;1822:1762–72.ArticlePubMed

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