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Review Article
Effect of Docosahexaenoic Acid (DHA) on Breast Cancer Cells
Sun-yong Hwang1, Tae-Hee Kim2, Hae-Hyeog Lee2, Heung Yeol Kim3, Juhyun Seo4
Kosin Medical Journal 2015;30(2):103-107.
Published online: January 20, 2015

1Department of Interdisciplinary Program in Biomedical Science, Soonchunhyang University Graduate School, Asan, Republic of Korea

2Department of Obstetrics and Gynecology, College of Medicine, Soonchunhyang University, Bucheon, Republic of Korea

3Department of Obstetrics and Gynecology, College of Medicine, Kosin University, Busan, Republic of Korea

4Department of Life Science and Biotechnology, Soonchunhyang University College of Natural Sciences, Asan, Republic of Korea

Corresponding Author: Tae-Hee Kim, MD, PhD, Department of Obstetrics and Gynecology, SoonchunhyangUniversity Bucheon Hospital, 170 Jomaru-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do, 14584, Korea TEL: +82-32-621-5380, Fax: +82-2-6008-6874 E-mail:;
• Received: September 15, 2015   • Accepted: September 16, 2015

Copyright © 2015 Kosin University School of Medicine Proceedings

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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  • Today, many materials as drug are developed having various prominent function in order to treatment of disease or cancer. Among these materials, especially docosahexaenoic acid (DHA), main constituents of omega-3 fatty acid, has a lot of beneficial and natural effects, so it has been known as anticancer material especially breast cancer. Breast cancer is disease taking high occurrence level among feminine diseases. DHA has anticancer effects on breast cancer cell, representatively inducing apoptosis, inhibiting proliferation or metastasis. Main effect of DHA on breast cancer cell is apoptosis inducing, which has mechanism that treated DHA causes lipid peroxidation increasing reactive oxygen species (ROS) level and it activates caspase 8 and caspase 9 so activated caspase occurs apoptosis. Cell lines of breast cancer are MDA-MB-231, MCF-7, SK-BR-3, T47D and ZR75. Especially this article uses the MCF-7 cell line at experiment of anti-proliferation by DHA, the MDA-MB-231 cell line at experiment of anti-metastasis by DHA, because that cell line has specialized metastasis activity. Therefore, this paper discusses the effects of natural material DHA as drug of breast cancer.
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      Effect of Docosahexaenoic Acid (DHA) on Breast Cancer Cells
      Kosin Med J. 2015;30(2):103-107.   Published online January 20, 2015
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