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Case Report
A Case of Glomerulonephritis Associated with Klinefelter' Syndrome - Jin Hyuk Cho, Yeoung Sin Sin, Eun Hee Sim, Min Gyu Park, Dong Heo, Hak Rim
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Kosin Medical Journal 2012;27(2):177-180.
DOI: https://doi.org/10.7180/kmj.2012.27.2.177
Published online: December 27, 2012
1Department of Internal Medecine, Dae Dong Hospital, Busan, Korea.
2Department of Nephrology, College of Medicine, Kosin University, Gospel Hospital, Busan, Korea.
- Corresponding Author: Jin Hyuck Cho, Department of internal medecine, Dae Dong Hospital, Myeongnyun-dong, Dongnae-gu, Busan 607-711, Korea. TEL: +82-10-5334-7508, FAX: +82-51-553-7575, happy2639@hanmail.net
• Received: June 14, 2012 • Revised: July 25, 2012 • Accepted: August 5, 2012
Copyright © 2012 Kosin University College of Medicine
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Abstract
- Klinefelter' syndrome is a disorder of sexual differentiation in males, characterized by the presence of two or more X-chromosomes, hypogonadism, and lack of secondary sexual characteristics. The association between Klinefelter' syndrome and glomerulonephritis has been reported, while cases of glomerulonephritis associated with Klinefelter' syndrome are rare. We report the Korean case: a 31-year-old man with Klinefelter' syndrome who developed glomerulonephritis. The patient's urine analysis shows microscopic hematuria and the result of kidney biopsy was minimal change disease. The onset and course of his disease might have been influenced by the sex hormone imbalance.
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XML DownloadA Case of Glomerulonephritis Associated with Klinefelter' Syndrome
Fig. 1
The patient's karyotype is compatible with Klinefelter' syndrome.
Fig. 2
Light microsccopic finding of kidney biopsy shows no definite abnormal finding except mild increase of mesangeal matrix (× 200, H & E staining).
Fig. 3
Electron microscopic finding of kidney biospy shows focal effacement of foot process.
Fig. 1
Fig. 2
Fig. 3
A Case of Glomerulonephritis Associated with Klinefelter' Syndrome
