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Original Article
A Case of Ischemic Colitis Related with Usual Dosage of Ibuprofen in a Young Man - Eun Jeong Kim, Moo In Park, Seun Ja Park, Won Moon, Go Eun Yeo, Weon Hyoung Lee
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Kosin Medical Journal 2014;29(2):147-150.
DOI: https://doi.org/10.7180/kmj.2014.29.2.147
Published online: December 18, 2014
1Department of Internal Medicine, College of Medicine, Kosin University Busan, Korea
- Corresponding Author : Moo In Park, Division of Gastroenterology, Department of Internal Medicine, Kosin University Gospel Hospital, 262, Kamcheon-ro, Seo-gu, Busan, 602-702, Korea TEL: +82-51-990-5133 FAX: +82-51-990-3049 E-mail: mipark@kosinmed.or.kr
• Received: July 17, 2013 • Accepted: December 16, 2013
Copyright © 2014 Kosin University School of Medicine Proceedings
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Abstract
- Ischemic colitis is a medical condition in which inflammation and injury of the large intestine result from inadequate blood supply. Although unoommon in the general p㢌pulation, ischemic colitis occurs with greater frequency in the elderly, and is the most common form of bowel ischemia. Other possible causes include medications s䴸ch as NSAIDs(non-steroidal antiinflammatory drugs), oral contraceptives, diuretics and others. In recent years, many of NSAID use in young age can cause ischemic lesions, but it is not common. Here we report a case of ischemic colitis in a 31-year-old man who had no specific medical history except taking 200mg of ibuprofen three times a day for seven days. It suggests the importance of precise history taking, including medications usage such as NSAIDs and other risk factors.
Fig 1.Abdominal comp䴸terized tomography showed the wall thickening of the colons, from ascending to transverse colon, and a small amᄋ䴸nt of the fluid in the right lower abdomen. The scans are otherwise 䴸nremarkable.
Fig 2.C㢌onoscopy showing hyperemic granular and easy friable m䴸cosa, with linear 䴸lcers running along the longit䴸dinal axis from ascending to transverse c㢌on.
Fig 3.C㢌onscopic biopsy showing loss of the s䴸rface epitheli䴸m, s䴸perficial m䴸cosal necrosis, and hemorrhagic foci in the lamina propria and lymhocyte cell infiltration.
Fig 4.Abdominal angiographic comp䴸terized tomography showing patent mesenteric vessels and no other abnormal findings
Fig 5.Colonoscopy performed at 7 days of admission showed several ᅵongit䴸dinaᅵ hyperemic m䴸cosa form ascending colon to transverse c㢌on, improving compared with the previo䴸s st䴸dy.
- 1.Higgins PD, Davis KJ, Laine L. Systematic review: the epidemiology of ischaemic colitis. Aliment Pharmacol Ther 2004;19:729–38.ArticlePubMedPDF
- 2.Green BT, Tendler DA. Ischemic colitis: a clinical review. South Med J 2005;98:217–22.ArticlePubMed
- 3.Gibson GR, Whitacre EB, Ricotti CA. Colitis induced by Nonsteroidal anti-inflammatory drugs. Report of and review of the literature. Arch Intern Med 1992;152:625–32.ArticlePubMed
- 4.Bjarnason I, Hayllar J, MacPherson AJ, Russell AS. Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans. Gastroenterology 1993;104:183–47.Article
- 5.Carratu R, Parisi P, Agozzino A. Segmental ischaemic colitis associated with nonsteroidal antiinflammatory drugs. J Clin Gastroenterol. 1993;16:31–4.PubMed
- 6.Appu S, Thompson G. Gangrenous ischemic colitis following non-steroidal anti inflmmatory drug overdose. ANZ J Surg 2001;71:694–5.PubMed
- 7.Vane JR. Inhibition of prostaglandin synthesis as a mechanism of action of aspirin - like drugs. Nat New Bial 1971;231:232–5.
- 8.Mahmud T, Rafi SS, Scott DL, Wrigglesworth JM, Bjarnason I. Nonsteroidal antiinflammatory drugs and uncoupling of mitochondrial oxidative phosphorylation. Arthritis Rheum 1996;39:1998–2003.ArticlePubMed
- 9.Brune K, Schweitzer A, Eckert H. Parietal cells of the stomach trap salicylates during absorption. Biochem Pharmacol 1977;26:1735–40.ArticlePubMed
- 10.Davies NM, Wallace JL. Nonsteroidal anti-inflammatory drug-induced gastrointestinal toxicity: New insights into an old problem. J Gastroenterol 1997;32:127–33.ArticlePubMed
- 11.Appleyard CB, McCafferty DM, Tigley AW, Swain MG, Wallace JL. Tumor necrosis factor mediation of NSAID-induced gastric damage: role of leukocyte adherence. Am J Physiol 1996;270:G42–8.ArticlePubMed
- 12.Aabakken L, Osnes M. Non-steroidal anti-inflammatory drug-induced disease in the distal ileum and large bowel. Scand J Gastroenterol Suppl 1989;163:48–55.ArticlePubMed
- 13.Gargot D, Chaussade S, d'Alteroche L, Desbazeille F, Grand-jouan S, Louvel A, et al. Non-steroidal anti-inflammatory drug-induced colonic strictures: two cases and literature review. Am J Gastroenterology 1995;90:2035–8.
- 14.Gut A, Halter F, Ruchti C. Nonsteroidal antirheumatic drugs and acetylsalicylic acid: adverse affects distal to the duodenum. Schweiz Med Wochenschr 1996;126:616–25.PubMed
- 15.Bjarnason I, Hayllar J, MacPherson AJ, Russell AS. Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans. Gastroenterology 1993;104:1832–47.ArticlePubMed
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