, Won Moon
, Kyoungwon Jung
, Jae Hyun Kim
, Sung Eun Kim
, Moo In Park
, Seun Ja Park
Department of Internal Medicine, Kosin University Gospel Hospital, Kosin University College of Medicine, Busan, Korea
© 2026 Kosin University College of Medicine.
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Conflicts of interest
Won Moon is the Editor-in-Chief and Sung Eun Kim is an editorial board member of the journal but was not involved in the peer reviewer selection, evaluation, or decision process of this article. No other potential conflicts of interest relevant to this article were reported.
Funding
None.
Author contributions
Conceptualization: MHL, WM. Data curation: MHL, WM. Investigation: MHL, WM. Methodology: WM. Project administration: WM. Resources: MHL. Supervision: WM. Validation: KJ, JHK, SEK, MIP, SJP. Visualization: MHL. Writing-original draft: MHL, WM. Writing-review & editing: all authors. All authors read and approved the final manuscript.
| Risk factors | Practical implications in practice |
|---|---|
| Prior inadequate bowel preparation | Use intensified regimen, earlier special diet, clearer instructions; consider preprocedure check and low threshold for rescue or early rescheduling. |
| Chronic constipation or infrequent bowel movements, baseline laxative use | Consider earlier low-residue diet, split-dose PEG-based regimen, and adjunct laxatives (e.g., bisacodyl) when appropriate; provide reinforcement and reminders. |
| High comorbidity burden (e.g., diabetes, neurologic disease), limited mobility | Expect slower transit and adherence barriers; simplify instructions, engage caregiver, and consider supervised pathways if needed. |
| Exposure to medication that impairs motility (e.g., opioids, anticholinergics, tricyclics, iron/calcium) | Review medications and anticipate reduced efficacy; consider intensified regimens and symptom control for nausea. |
| Older age, frailty, cognitive impairment | Prioritize safety and completion; use predictable agents (often PEG), hydration plan, caregiver support, and fall-risk precautions. |
| CKD or electrolyte vulnerability | Avoid oral sodium phosphate; use caution with magnesium-containing agents; consider selective labs in advanced CKD or frailty. |
| Inpatient status, acute illness, competing tests/scheduling constraints | Use protocolized inpatient order sets with nursing monitoring of intake/output; coordinate timing with procedure schedule. |
| Poor health literacy, language barriers, limited social support | Use standardized written instructions, teach-back, reminders (text message/phone), and involve family/caregiver. |
| Short lead time to colonoscopy, early-morning procedures | Ensure true split dose when feasible; provide clear timing schedule; consider same-day regimen for afternoon cases when appropriate and safe. |
| Population | Preferred agents | Timing and diet | Special considerations | Monitoring and rescue |
|---|---|---|---|---|
| Inflammatory bowel disease | PEG-based solutions as first-line | Split dose; emphasize completion; standard low-residue diet per institutional policy | Interpret subtle lesions with awareness of prep-related mucosal changes (especially after sodium phosphate); prioritize visualization for activity assessment/surveillance | Early recognition of incomplete intake; low threshold for intensified or repeat preparation when visualization is critical |
| CKD | PEG-based solutions preferred; avoid sodium phosphate | Split dose; hydration plan | Use caution with magnesium-containing agents (advanced CKD); review diuretics/RAAS blockers; avoid dehydration | Consider selective electrolytes/renal function monitoring in advanced CKD or frailty; favor PEG-based rescue |
| Older adults | PEG-based regimens with predictable safety; consider low-volume PEG in selected patients | Split dose; simplify instructions; consider supervised preparation if there are adherence barriers | Assess frailty, mobility, cognition; caregiver engagement; fall-risk precautions | Hydration plan and medication review; early assessment for rescue or rescheduling if inadequate |
| Chronic constipation/hard-to-prepare outpatients | PEG-based regimens; consider higher-volume or adjuncts | Earlier dietary modification; split dose; reinforced education | Ask about prior inadequate preparation; consider adjunct laxatives (e.g., bisacodyl) when appropriate | Preprocedure effluent assessment; rescue strategy or early repeat colonoscopy if inadequate |
| Hospitalized patients | PEG-based regimens commonly used within protocolized pathways | Split dose aligned to schedule; standardized orders and diet | Address nausea/pain, opioid exposure; nursing documentation of intake/output and stool quality | Protocol-driven early assessment; presedation rescue or rescheduling to avoid low-yield procedures |
PEG, polyethylene glycol; CKD, chronic kidney disease.
PEG, polyethylene glycol; CKD, chronic kidney disease; RAAS, renin–angiotensin–aldosterone system.