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Original Article
Comparative Study of an Ondansetron and a Ramosetron an Aprepitant in the Control of Nausea and Vomiting in Gynecologinc Cancer Patient with Chemotherapy
HANGGOO Yun, Heung Yeol Kim, Eun ae Jeh
Kosin Medical Journal 2013;28(2):115-121.
DOI: https://doi.org/10.7180/kmj.2013.28.2.115
Published online: January 19, 2013

Department of Obstetrics and Gynecology, College of Medicine, Kosin University, Busan, Korea

Corresponding author: Heung Yeol Kim, Department of Obstetrics and Gynecology, College of Medicine, Kosin University, 34 Amnamdong, Seo-gu, Busan, 602-702, Korea TEL: +82-51-990-6226 FAX: +82-51-990-3300 E-mail: hykyale@yahoo.com
• Received: October 2, 2012   • Accepted: January 10, 2013

Copyright © 2013 Kosin University School of Medicine Proceedings

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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  • Results
    The efficacy of controlling nausea with an ondansetron regimen and a ramosetron regimen and an aprepitant regimen was 85.29%, 78.26%, 80% in acute periods (P-value = 0.037) and 88.23%, 98.26%, 87.5% in delayed periods (P-value = 0.000), respectively. The efficacy of controlling vomiting with an ondansetron regimen and a ramosetron regimen and an aprepitant regimen and an ondansetron regimen was 82.35%, 97.3%, 90% in acute periods (P-value=0.002) and 82.35%, 100%, 95% in delayed periods (P-value = 0.000), respectively. The common adverse effects in each groups were not significantly.
  • Conclusions
    Appropriate to each patient’s symptoms, the choice of drugs will be needed since each of the drugs have different effects on vomiting. Even though the each antiemetic drug has good efficacy, the effect of the drug is not complete. Therefore the use of additional drugs are also needed.
  • Objectives
    Chemotherapy induced nausea and vomiting is most distressing adversed effects in gynecologic cancer patients receiving chemotherapy. we compared effectiveness of ondansetron and ramosetron and aprepitant for optimal antiemetic treatment in gynecologic cancer patient receiving chemotherapy.
  • Methods
    The study was performed retrospective on 189 patients who was diagnosed initially the gynecological cancer during chemotherapy at Kosin university hospital between January 2008 and December 2010. The efficacy of controlling acute/delayed nausea and vomiting were analyzed by counting numbers of nausea and vomiting reported in medical records of 189 patient receiving cisplatin-based chemotherapy. Statistical analysis was performed using the ANOVA and Fisher’s exact chi-square test.
  • Results
    The efficacy of controlling nausea with an ondansetron regimen and a ramosetron regimen and an aprepitant regimen was 85.29%, 78.26%, 80% in acute periods (P-value = 0.037) and 88.23%, 98.26%, 87.5% in delayed periods (P-value = 0.000), respectively. The efficacy of controlling vomiting with an ondansetron regimen and a ramosetron regimen and an aprepitant regimen and an ondansetron regimen was 82.35%, 97.3%, 90% in acute periods (P-value=0.002) and 82.35%, 100%, 95% in delayed periods (P-value = 0.000), respectively. The common adverse effects in each groups were not significantly.
  • Conclusions
    Appropriate to each patient’s symptoms, the choice of drugs will be needed since each of the drugs have different effects on vomiting. Even though the each antiemetic drug has good efficacy, the effect of the drug is not complete. Therefore the use of additional drugs are also needed.
Table 1.
연구대상 환자군의 임상양상
Characteristics No. of patients
P-value
A (n = 40) O (n = 34) N (n = 115)
Age 57.1 ± 8.0 54.0 ± 6.4 53.47 ± 12.9 0.202
Cancer 0.013
o 10 12 58
c 30 22 57
Chemo 0.000
FP 10 13 40
CT 30 21 43
Other 0 0 32
Performance 0.004
0 26 22 96
1 11 10 19
2 3 2 0

Statistics were analyzed by ANOVA and Fisher’s exact chi-square test. mean ± SD, frequency (%).

Table 2.
Aprepitant, Ondansetron, Ramosetron 요법의 오심에 대한 조절 효과
Grade A (n = 40) O (n = 34) N (n = 115) P-value
Acute 0 23 22 44 0.037
1 9 7 46
2 8 5 24
3 0 0 0
Delayed 0 26 19 102 0.000
1 9 11 11
2 5 4 2
3 0 0 0

Statistics were analyzed by Fisher’s exact chi-square test.

Table 3.
Aprepitant, Ondansetron, Ramosetron 요법의 구토에 대한 조절 효과
Grade A (n = 40) O (n = 34) N (n = 115) P-value
Acute 0 27 21 100 0.002
1 9 7 12
2 4 6 3
3 0 0 0
Delayed 0 31 18 112 0.000
1 7 10 3
2 2 6 0
3 0 0 0

Statistics were analyzed by Fisher’s exact chi-square test.

Table 4.
Aprepitant, Ondansetron, Ramosetron 요법 간의 부작용
Aprepitant
Ondant
Nasea
N Sum N Sum N Sum
Dizziness 0   2 2 9 15
Diarrhea 7 11 6 8 5 10
Constipation 5 6 6 8 17 19
Epi. Soreness 3 3 4 4 21 44
Anorexia 6 6 5 5 25 37
Headache 3 3 4 4 11 12
Itching 1 1 1 1 10 12
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        Comparative Study of an Ondansetron and a Ramosetron an Aprepitant in the Control of Nausea and Vomiting in Gynecologinc Cancer Patient with Chemotherapy
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