Kosin Medical Journal

Risk factors for central and lateral lymph node metastasis in papillary thyroid carcinoma: Ji Hyun Ahn, Hee Kyung Chang; Kosin Med J. 2022;37(4):311-319. Published online December 19, 2022; DOI: https://doi.org/10.7180/kmj.22.136

1,066 View
29 Download
1 Citations

Background
Lymph node metastasis (LNM) is commonly observed in papillary thyroid carcinoma. This study aimed to investigate the risk factors for LNM in patients with papillary thyroid carcinoma.
Methods
The clinicopathological factors of 417 patients were investigated, and differences according to the presence or absence of LNM were evaluated.
Results
LNM was associated with age <55 years, male sex, tumor size >10 mm, multiple and bilateral tumors, tumor involving the lower pole or entire lobe, lymphovascular invasion (LVI), perineural invasion (PNI), and extrathyroidal extension (ETE). Univariable and multivariable analyses showed that age <55 years, male sex, tumor size >10 mm, LVI, and ETE were related to central LNM. Male sex, tumor size >10 mm, and LVI were correlated with lateral LNM (p<0.05). Compared to central LNM, more lymph nodes were involved in metastases and the metastatic tumors were larger in lateral LNM. Extranodal extension (ENE) was more commonly observed in lateral LNM (p<0.001) and was associated with tumor size >10 mm, multifocality, PNI, ETE, and the absence of lymphocytic thyroiditis (p<0.05).
Conclusions
Younger age, male sex, tumor size >10 mm, LVI, and ETE were risk factors for central LNM, while male sex, tumor size >10 mm, and LVI were risk factors for lateral LNM. ENE was more commonly observed in lateral LNM, and tumor size >10 mm, multifocal tumors, PNI, ETE, and tumors unrelated to lymphocytic thyroiditis were risk factors for ENE.

Citations

Citations to this article as recorded by

Alterations in the amino acid profile in patients with papillary thyroid carcinoma with and without Hashimoto’s thyroiditis
Andrzej Hellmann, Jacek Turyn, Agata Zwara, Justyna Korczynska, Aleksandra Taciak, Adriana Mika
Frontiers in Endocrinology.2023;[Epub] CrossRef

Analysis of factors related systemic recurrence after breast conserving surgery in stage I breast cancer: Yoon-Seok Kim, Dong-Won Ryu, Chung-Han Lee; Kosin Med J. 2018;33(3):289-296. Published online December 31, 2018; DOI: https://doi.org/10.7180/kmj.2018.33.3.289

938 View
3 Download

Abstract PDF PubReader: Objectives
In these days, patients with stage I breast cancer have increased by regular health examination and diagnostic tool development. The aim of this retrospective study is to identify systemic recurrence related factors after breast conserving surgery (BCS) for stage I breast cancer.
Methods
In this study, we analyzed the correlation between systemic recurrence and pathologic factors. We reviewed 223 patients who underwent BCS for stage I breast cancer. Postoperative pathologic factors, recurrent rates and sites were studied. In addition, preoperative patients'data were also collected. Statistical analysis was done by using PASW 16.0 (SPSS Inc., Chicago, IL, USA).
Results
Systemic recurrence was found in 16 patients (7.17%) within 5 years after primary surgery. 5 patients had lymphatic invasion and 6 patients had vascular invasion. Lymphatic and vascular invasion had statistical correlation with systemic recurrence (P = 0.004, P = 0.001).
Conclusions
In this retrospective study, we can conclude that vascular invasion and lymphatic invasion are related systemic recurrence after BCS for stage I patients. Further studies with large cohort will be required to fully understand the risk factors of systemic recurrence for stage I breast cancer patients.

Clinical findings and risk factors for Candida esophagitis: Sun Young Kim, Seung Hun Lee, Sung Hoon Kim, Jae Seung Lee, Hee Seung Park, Sung Ho Choi, Seun Ja Park; Kosin Med J. 2007;22(1):206-211. Published online June 30, 2007

210 View
0 Download

PDF

Relationship of Body Fat Distribution with Metabolic Risk Factors: Se Jin oh, Sang Jung Kang, Soo Keun Song, Dong Hyun Lim, Seong Man Kim, Young Sik Choi, Yo Han Park, Hyung Soo Cha; Kosin Med J. 2000;15(1):39-48.

276 View
0 Download

PDF

Search