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Original articles
Correlation of long interspersed element-1 open reading frame 1 and c-Met proto-oncogene protein expression in primary and recurrent colorectal cancers
Kyung-Yoon Jeon, Eun-Ji Ko, Hee-Kyung Chang, Seung-Hyun Lee, Byung-Kwon Ahn, Mee Sun Ock, Hee-Jae Cha
Kosin Med J. 2022;37(4):283-290.   Published online December 22, 2022
DOI: https://doi.org/10.7180/kmj.22.106
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Abstract PDFPubReader   ePub   
Background
Colorectal cancer is one of the most common cancers worldwide. Colorectal cancer that has recurred and metastasized to other organs also has a very poor prognosis. According to recent studies, the long interspersed element-1 (LINE-1) retrotransposon open reading frame (ORF) is located in the intron of the c-Met proto-oncogene, which is involved in cancer progression and metastasis, and regulates its expression. However, no study has compared the expression patterns of LINE-1 ORF1 and c-Met, which are closely related to cancer progression and metastasis, and their correlation in primary and recurrent cancers.
Methods
In the present study, we compared the expression patterns of LINE-1 ORF1 and c-Met in both primary and recurrent colorectal cancer tissues from 10 patients. Expression patterns and correlations between LINE-1 ORF1 and c-Met proto-oncogene proteins were analyzed by immunofluorescence staining using both LINE-1 ORF1 and c-Met antibodies.
Results
The expression patterns of LINE-1 ORF1 and c-Met showed significant individual differences, and the expression of both proteins was correlated in all colorectal cancer patients. However, the expression levels of LINE-1 ORF1 and c-Met were not significantly different between primary and recurrent colorectal cancers.
Conclusions
The protein expression levels of LINE-1 ORF1 and c-Met were correlated, but did not change significantly in cases of recurrent colorectal cancer in the same patient.

Citations

Citations to this article as recorded by  
  • Functional Analysis of Membrane-Associated Scaffolding Tight Junction (TJ) Proteins in Tumorigenic Characteristics of B16-F10 Mouse Melanoma Cells
    Eun-Ji Ko, Do-Ye Kim, Min-Hye Kim, Hyojin An, Jeongtae Kim, Jee-Yeong Jeong, Kyoung Seob Song, Hee-Jae Cha
    International Journal of Molecular Sciences.2024; 25(2): 833.     CrossRef
Gamma Knife Radiosurgery in Recurrent Trigeminal Neuralgia after Other Procedures
Jae Meen Lee, Beong Ik Hur, Chang Hwa Choi
Kosin Med J. 2019;34(1):30-37.   Published online June 30, 2019
DOI: https://doi.org/10.7180/kmj.2019.34.1.30
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Abstract PDFPubReader   ePub   
Objectives

Trigeminal neuralgia (TN) is undurable paroxysmal pain in the distribution of the fifth cranial nerve. Invasive treatment modalities for TN include microvascular decompression (MVD) and percutaneous procedures, such as, radiofrequency rhizotomy (RFR). Gamma Knife radiosurgery (GKRS) is a considerable option for patients with pain recurrence after an initial procedure. This study was undertaken to analyze the effects of gamma knife radiosurgery in recurrent TN after other procedures.

Methods

Eleven recurrent TN patients after other procedures underwent GKRS in our hospital from September 2004 to August 2016. Seven patients had previously undergone MVD alone, two underwent MVD with partial sensory rhizotomy (PSR), and two underwent RFR. Mean patient age was 60.5 years. We retrospectively analyzed patient's characteristics, clinical results, sites, and divisions of pain. Outcomes were evaluated using the Visual Analog Scales (VAS) score.

Results

Right sides were more prevalent than left sides (7:4). The most common distribution of pain was V1 + V2 division (n = 5) following V2 + V3 (n = 3), V2 (n = 2), and V1 + V2 + V3 (n = 1) division. Median GKRS dose was 80 Gy and the mean interval between the prior treatment and GKRS was 74.45 months. The final outcomes of subsequent GKRS were satisfactory in most cases, and at 12 months postoperatively ten patients (90.0%) had a VAS score of ≤ 3.

Conclusions

In this study, the clinical result of GKRS was satisfactory. Invasive procedures, such as, MVD, RFR are initially effective in TN patients, but GKRS provides a safe and satisfactory treatment modality for those who recurred after prior invasive treatments.

Case report
A case of nonrecurrent laryngeal nerve
Jae Young Choi, Ju Won Yoon, Jeong Hoon Kim
Kosin Med J. 2007;22(1):259-261.   Published online June 30, 2007
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Original article
Usefulness of Cryosurgery on Recurrent or Persistent Prostatic Cancer After Radiation Therapy
Hyun Yul Rhew, Chang Kyu Lee, Andrew C. von Eschenbach
The Journal of Kosin Medical College. 1996;11(1-2):39-48.
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Case report
A Case of Diverticulitis Operated due to Recurrent Abdominal Pain
Jung Pil Park, Jin Wuk Hur, Sin Kim, Yu Ri Kim, Chan Bog Park, Hyun Jeung Lim, Jee Young Lee, Moo In Park, Seun Ja Park, Bong Guen Chun, Byung Kwon Ahn, Ja Young Koo
Kosin Med J. 2004;19(1):118-122.
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KMJ : Kosin Medical Journal