Kosin Medical Journal

Correlation of long interspersed element-1 open reading frame 1 and c-Met proto-oncogene protein expression in primary and recurrent colorectal cancers: Kyung-Yoon Jeon, Eun-Ji Ko, Hee-Kyung Chang, Seung-Hyun Lee, Byung-Kwon Ahn, Mee Sun Ock, Hee-Jae Cha; Kosin Med J. 2022;37(4):283-290. Published online December 22, 2022; DOI: https://doi.org/10.7180/kmj.22.106

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Background
Colorectal cancer is one of the most common cancers worldwide. Colorectal cancer that has recurred and metastasized to other organs also has a very poor prognosis. According to recent studies, the long interspersed element-1 (LINE-1) retrotransposon open reading frame (ORF) is located in the intron of the c-Met proto-oncogene, which is involved in cancer progression and metastasis, and regulates its expression. However, no study has compared the expression patterns of LINE-1 ORF1 and c-Met, which are closely related to cancer progression and metastasis, and their correlation in primary and recurrent cancers.
Methods
In the present study, we compared the expression patterns of LINE-1 ORF1 and c-Met in both primary and recurrent colorectal cancer tissues from 10 patients. Expression patterns and correlations between LINE-1 ORF1 and c-Met proto-oncogene proteins were analyzed by immunofluorescence staining using both LINE-1 ORF1 and c-Met antibodies.
Results
The expression patterns of LINE-1 ORF1 and c-Met showed significant individual differences, and the expression of both proteins was correlated in all colorectal cancer patients. However, the expression levels of LINE-1 ORF1 and c-Met were not significantly different between primary and recurrent colorectal cancers.
Conclusions
The protein expression levels of LINE-1 ORF1 and c-Met were correlated, but did not change significantly in cases of recurrent colorectal cancer in the same patient.

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Functional Analysis of Membrane-Associated Scaffolding Tight Junction (TJ) Proteins in Tumorigenic Characteristics of B16-F10 Mouse Melanoma Cells
Eun-Ji Ko, Do-Ye Kim, Min-Hye Kim, Hyojin An, Jeongtae Kim, Jee-Yeong Jeong, Kyoung Seob Song, Hee-Jae Cha
International Journal of Molecular Sciences.2024; 25(2): 833. CrossRef

Imaging of F-18 FDG PET/CT and follow up of bilateral invasive adrenal diffuse large B cell lymphoma mimicking adrenocortical carcinoma: Hye Kyung Shim, So Woon Kim; Kosin Med J. 2017;32(2):269-276. Published online December 29, 2017; DOI: https://doi.org/10.7180/kmj.2017.32.2.269

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Abstract PDF PubReader ePub: The incidence of malignant adrenal tumors, including primary adrenal lymphoma (PAL) and adrenocortical carcinoma (ACC), is rather low. Early differentiation between ACC and PAL is necessary because the therapeutic strategies for the two differ and the prognosis of each disease is poor. Unfortunately, there is no pathognomonic characteristic of PAL, so radiologists have difficulty in differentiating it from ACC. To our knowledge, there have been only two case reports on ACC that was evaluated and followed up using F-18 FDG PET/CT. The previously reported cases were simple, involving only the bilateral adrenal glands. Here, we report on a 52-year-old man diagnosed with PAL that radiologically mimicked ACC. He had findings of heterogeneous enhancement on CT, several adjacent lymphadenopathies with internal necrosis, and abutting hepatic and bilateral crural invasion. After pathological confirmation, we monitored his prognosis using F-18 FDG PET/CT after three cycles of rituximab-CHOP and again after six cycles of treatment.

A Case of Treatment with Steroid and Hydrochloroquine of Thrombocytopenia in Primary Sjögren's Syndrome: Yeong Seop Yun, Ji Wook Choi, Young Jae Doo, Tae Hyung Kim, Hye Lim Oh, Ji Min Oh; Kosin Med J. 2017;32(1):118-126. Published online June 30, 2017; DOI: https://doi.org/10.7180/kmj.2017.32.1.118

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Abstract PDF PubReader ePub: Sjögren's syndrome is a systemic autoimmune disease characterized by sicca symptoms and extraglandular manifestations. Anemia, leukopenia, thrombocytopenia and lymphoproliferative disorders are well-known extraglandular, hematological complications of Sjögren's syndrome. These hematologic alterations are usually mild and respond well with steroid therapy. We report a case of a 52-year-old female patient who was initially presented with thrombocytopenia. The patient was then diagnosed with primary Sjögren's syndrome and initially treated with steroid. The patient's platelet count was decreased when steroid was tapered. The dose of steroid could be effectively reduced after combined medication with hydroxychloroquine.

Therapeutic comparison of Surgery combined with chemotherapy and chemotherapy alone for Primary Gastrointestinal Lymphoma: A single center study: Je Hun Kim, Ho Sup Lee, Jun Seop Lee, Jin Young Lee, Su Young Kim, Cheol Su Kim, Joung Wook Yang, Ga In You; Kosin Med J. 2015;30(1):29-39. Published online January 20, 2015; DOI: https://doi.org/10.7180/kmj.2015.30.1.29

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Abstract PDF PubReader ePub: Abstract Objectives
There is still no consensus on the optimal treatment for primary gastrointestinal lymphoma (PGIL). The aim of this study was to compare surgery combined with chemotherapy and chemotherapy alone in PGIL.
Methods
We retrospectively reviewed and analyzed the treatment outcomes of 107 patients with primary gastrointestinal lymphoma diagnosed between March 1999 and December 2009 at Kosin University Gospel Hospital. Patients were divided into two groups: 35 patients who underwent surgery combined with chemotherapy (group A) and 72 patients who were treated with chemotherapy alone (group B). And we analyzed prognostic factors associated with short survival.
Results
The 5-year progression free survival rates (PFS) of group A and B were 86.7% and 66.1%, respectively (P = 0.037), while the 5-year overall survival rates (OS) were 86.8% and 68.4%, respectively (P = 0.129). In multivariate analysis, Both PFS and OS were not changed by treatment strategies (surgery combined with chemotherapy or chemotherapy only). The international prognostic index (IPI) was the only independent predictive factor for PFS.
Conclusions
In our study, surgery combined with chemotherapy and chemotherapy only make no difference of survival rate. And further randomized prospective studies are needed to confirm a treatment strategies at improving survival outcomes in PGIL patients.

Primary Repair of Collateral Ligaments Injury in Simple Elbow Joint Dislocation Using the Suture Anchor: Gu Hee Jung; Kosin Med J. 2009;24(1):18-22. Published online June 30, 2009

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A Case of Granulocytic Sarcoma: Sook Ja Park, Jin Sook Lee, Jae Sun Park; The Journal of Kosin Medical College. 1990;6(2):177-184.

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Two cases of Primary Hyperparathyroidism: Joong Kyou Kim, Yoon Hoi Koo, Sung Do Lee, Bang Hur, Man Ha Heo, Sang Kyun Bae, Ha Yong Yum; The Journal of Kosin Medical College. 1995;10(2):71-78.

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Percutaneous Needle Biopsy of Bone Lesions: Accuracy, Effective Accuracy, and Diagnostic Utility: Byung Kook Cheon, Jin Do Huh, Jong Min Kim, Kyung Seoung Oh, Gyoo Sik Jung, Yung Duk Joh; The Journal of Kosin Medical College. 1996;11(1-2):49-56.

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A Case of Primary Cutaneous Cryptococcosis Treated with Itraconazole: Hyun Cheol Kim, Yeong Jin Kim, Young Soo Chae, Kee Suck Suh, Sang Tae Kim; The Journal of Kosin Medical College. 1996;11(1-2):113-120.

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A Case of Small Sized Primary Malignant Lymphoma of the Thyroid: Dal Soo Park, Jin Hyung Lim, Jun Chul Pyun, Young Soo Lee, Young Sik Choi, Yo Han Park, Joong Kyou Kim, Hee Kyung Chang; The Journal of Kosin Medical College. 1998;13(1-2):45-51.

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A Case of Primary Small Cell Carcinoma of the stomach: Seoung Hoon Kim, Jee Yeon Kim, Hyun Young Kim, Chae Hee Shin, Dong Wan Kim, Ki Hwan Kim, Hyeong Young Park Moo In Park, Seun Ja Park, Ja Young Koo; Kosin Med J. 2002;17(1):157-160.

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Primary Lymphoma of the Common Bile Duct A Case Report: Bong-Kwon Chun; Kosin Med J. 2004;19(1):47-52.

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Clinical Characteristics and Follow-up study in Primary Female Urethral Tumors: Chang Ho Jung, Hyun Yul Rhew; Kosin Med J. 2004;19(1):184-194.

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Two Cases of Hypokalemic Periodic Paralysis due to Primary Aldosteronism: Ji Hyun Lee, Ji Su Moon, Min Jeong Kim, Bong Goo Yoo, Kwang Soo Kim; Kosin Med J. 2005;20(1):72-75.

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A Case of Primary Malignant Melanoma of the Vagina: Jong-Soon Choi, chun june lee; Kosin Med J. 2006;21(1):53-57.

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