Kosin Medical Journal

Locally recurrent primary adrenal leiomyosarcoma discovered incidentally 7 years after initial surgery: a case report: Myungsoo Im, Doohwa Kim, Soree Ryang, Bo Hyun Kim; Kosin Med J. 2026;41(1):85-90. Published online March 20, 2026; DOI: https://doi.org/10.7180/kmj.25.129

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Abstract PDF PubReader ePub: Primary adrenal leiomyosarcoma (PAL) is an aggressive, rare tumor that is frequently diagnosed at an advanced stage. We report the case of a 65-year-old female patient with hypertension who presented with stabbing lower abdominal pain and unintentional weight loss. Abdominal computed tomography (CT) demonstrated a 10.4×8.2×8.1 cm heterogeneous left adrenal mass without biochemical evidence of hormonal hypersecretion. Retroperitoneal left adrenalectomy was performed without complications, and histopathological examination confirmed a moderately differentiated adrenal leiomyosarcoma. The patient was followed at the outpatient oncology clinic for 5 years with no evidence of recurrence. Seven years after the initial surgery, a newly detected left suprarenal mass was identified on imaging. Abdominal CT revealed a new, well-circumscribed 7.1×6.4×6.2 cm heterogeneous mass. Laparoscopic resection of the recurrent mass was performed. Pathological examination again revealed a moderately differentiated leiomyosarcoma with positive surgical margins but no lymphovascular invasion. Immunohistochemical staining was positive for smooth muscle actin, desmin, h-caldesmin, neuron-specific enolase, and synaptophysin, findings consistent with recurrent adrenal leiomyosarcoma. This case demonstrates that PAL can recur locally after prolonged disease-free intervals, underscoring the importance of extended surveillance, potentially beyond 10 years.

Primary gastric leiomyosarcoma: a case report and literature review: Yedaun Lee; Kosin Med J. 2024;39(1):60-65. Published online August 18, 2023; DOI: https://doi.org/10.7180/kmj.23.118

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After separating gastrointestinal (GI) stromal tumors from true smooth muscle tumors of the GI tract, leiomyosarcoma (LMS) of the GI tract has become a rare tumor. Gastric LMS is extremely rare and accounts for 0.1% of all cases of LMS in the GI tract. There are few English-language reports of gastric LMS describing radiologic findings. Here, we report a case of gastric LMS and review the recent literature focusing on radiologic findings. An 80-year-old female patient was referred for evaluation of a gastric mass accompanied by severe anemia. The physical examination revealed no specific findings except for an anemic conjunctiva. Laboratory data showed a low hemoglobin level of 5.1 g/dL. Endoscopy revealed a huge subepithelial mass in the posterior wall of the gastric body. Contrast-enhanced computed tomographic images showed an intraluminal protruding enhancing mass with an internal stalk appearance in the gastric body. There was no internal necrosis or calcification. The patient underwent subtotal gastrectomy and was diagnosed with primary gastric LMS. The diagnosis of gastric LMS is challenging due to its rarity. Our case report suggests that the presence of an internal stalk or spouting appearance can help prompt the radiologist to consider gastric LMS in the differential diagnosis.

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Pleomorphic gastric leiomyosarcoma with retroperitoneal extension and hepatic metastasis: A case report
Kun Huang, Wen Wang, Mei-Ling Xu, Yun-Shen He, Jiang-Ying Zhao, Xiao-Feng Hu
World Journal of Gastrointestinal Surgery.2026;[Epub] CrossRef

A Clinical Study of 12 Cases of Uterine Sarcoma: Heung Yeol Kim, Un Dong Park; The Journal of Kosin Medical College. 1992;8(2):197-206.

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A case of Leiomyosarcoma of the Vulva: Bae Geun Yoon, Un Dong Park; The Journal of Kosin Medical College. 1993;9(1):91-96.

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Leiomyosarcoma of the Vulva: Myeong Su Jeon, Wan Kyu Eo, Heung Yeon Kim; Kosin Med J. 2006;21(2):183-186.

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