Kosin Medical Journal

The solid predominant subtype as an independent risk factor for recurrence in patients with pathologic stage I lung adenocarcinoma: Chul Ho Lee, Yun-Ho Jeon; Kosin Med J. 2023;38(2):117-125. Published online June 8, 2023; DOI: https://doi.org/10.7180/kmj.23.103

Abstract PDF PubReader ePub: Background
Increasingly many patients have been diagnosed with stage I adenocarcinoma due to the use of low-dose chest computed tomography for lung cancer screening. Therefore, this study aimed to analyze tumor recurrence based on the predominant subtype in patients with stage I lung adenocarcinoma who underwent lobectomy.
Methods
We retrospectively analyzed 114 patients who underwent lobectomy for pathologic stage I lung adenocarcinoma from June 2001 to July 2019.
Results
In univariate analyses, significant factors were current smoking at the time of surgery (p=0.029), pathologic tumor size (p=0.006), central tumor location (p=0.003), maximum standardized uptake value on positron emission tomography-computed tomography (p=0.001), and the solid predominant subtype (p=0.012). In the multivariate analysis, only the solid predominant subtype (hazard ratio, 9.702; 95% confidence interval, 1.179–79.874; p=0.035) was an independent risk factor.
Conclusions
If the solid subtype is predominant in pathologic findings, adjuvant chemotherapy after standard surgical resection may be considered to help reduce the risk of tumor recurrence and increase survival.

A case report of successfully treated metachronous gastrointestinal stromal tumor and colon cancer: Young Jin Heo, Ji Young Lee; Kosin Med J. 2023;38(1):60-65. Published online March 8, 2023; DOI: https://doi.org/10.7180/kmj.22.138

Abstract PDF PubReader ePub: The diagnosis of gastrointestinal stromal tumor (GIST) has become relatively common in recent years, but little is known about its association with other malignancies. We present a rare case of successfully treated metachronous GIST and colon cancer with concurrent FOLFOX (5-fluorouracil, leucovorin, and oxaliplatin) chemotherapy and imatinib. A 63-year-old man presented with abdominal pain that had started 2 weeks ago, and endoscopic ultrasonography showed masses that were compatible with GIST on the duodenum. He underwent Whipple surgery. One year after the GIST diagnosis, two liver masses were found on abdominal computed tomography images taken for surveillance. A liver biopsy showed metastatic adenocarcinoma, not GIST. Colonoscopy was then performed to identify the primary site of the metastatic adenocarcinoma in the liver, and sigmoid colon cancer was found. He received 12 cycles of adjuvant FOLFOX concurrently with adjuvant imatinib. There were no serious adverse events of grade 3 or higher from either imatinib or chemotherapy. He has completed adjuvant imatinib and FOLFOX chemotherapy and there is no evidence of disease recurrence. When a synchronous or metachronous tumor is found in a GIST patient, the clinician should keep in mind the possibility of another primary tumor of different histopathology, as well as GIST recurrence.

Metachronous anterior urethral metastasis of prostatic ductal adenocarcinoma: Jeong Hyun Oh, Taek Sang Kim, Hyun Yul Rhew, Bong Kwon Chun; Kosin Med J. 2016;31(1):66-70. Published online February 4, 2016; DOI: https://doi.org/10.7180/kmj.2016.31.1.66

Abstract PDF PubReader ePub: Abstract
Prostate cancer is increasing in frequency in Korea. Among them, ductal adenocarcinoma (DCP) has a more aggressive and poor prognosis than acinar adenocarcinoma (ACP), despite its low incidence. Patients usually present with symptoms of lower urinary tract symptoms and hematuria due to increasing tumor mass within the lumen of the prostatic urethra, making diagnosis of DCP by the transrectal prostate biopsy difficult. DCP is often metastasized at the time of diagnosis. DCP is transferable to most other organs but the metastasis to the anterior urethra is rare. There is no doubt that localized DCP requires radical prostatectomy (RP) but the guidelines for adjuvant therapy after RP have not yet been established. Methods of the treatment are confounded by individual differences, and arriving at a consensus is challenging due to insufficient data. We report a case of DCP and urethral metastasis after RP, thus aiding in the determination of treatment guidelines.

Conservative Treatment of Endometrial Cancer in A Young Woman with Infertility Caused by Chronic Anovulation: Jong Yeol Choi, Chun Jun Lee, Won Gyu Kim; Kosin Med J. 2007;22(2):155-160. Published online December 31, 2007

Stein-Leventhal Syndrome associated with Endometrial Adenocarcinoma - A Case Report -: Bang Hur, In Sun Jun, Man Ha Huh; The Journal of Kosin Medical College. 1990;6(1):105-112.

Conservative Approach for Treatment of Endometrial Carcinoma in Young Age Associated with Infertility caused by Chronic Anovulation: Won Gue Kim; The Journal of Kosin Medical College. 1993;9(2):129-136.

A Case of Urachal Adenocarcinoma: Chang Kyu Lee, Seong Choi, Jong Chul Kim, Hyun Yul Rhew; The Journal of Kosin Medical College. 1994;10(1):63-67.

A Case of Primary Signet Ring Cell Adenocarcinoma of Uterine Cervix: Tae Hwa Lee, chun june lee, Sung Han Kim; Kosin Med J. 2006;21(2):166-169.

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