Kosin Medical Journal

Review articles

Gout in the era of multimorbidity: pathogenesis, systemic comorbidities, and evolving therapeutic strategies: Phillip J Kim, Jihun Kang, Jesang Yu, Geun-Tae Kim, Yunkyung Kim; Kosin Med J. 2026;41(1):26-36. Published online March 31, 2026; DOI: https://doi.org/10.7180/kmj.26.159

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Abstract PDF PubReader: Gout is the most prevalent inflammatory arthritis worldwide and represents a growing global health burden. It arises from hyperuricemia resulting from disordered purine metabolism, leading to monosodium urate (MSU) crystal deposition and recurrent inflammatory arthritis. Although hyperuricemia is the principal risk factor, genetic susceptibility, impaired urate transport, and emerging factors such as the gut microbiota also contribute to disease development. Acute flares are mediated by MSU crystal-induced activation of the NLRP3 inflammasome and subsequent interleukin-1β production, whereas chronic inflammation results in tophus formation and structural joint damage. Gout is closely associated with metabolic syndrome, chronic kidney disease, and cardiovascular disease, which contribute to persistently elevated mortality. Although advances in imaging and pharmacologic therapy have improved diagnosis and management, the real-world use of urate-lowering therapy remains suboptimal. Further research and sustained efforts by healthcare professionals are needed to improve long-term disease control.

Current understanding of modulated electro-hyperthermia in cancer treatment: Sungmin Kim, Jesang Yu, Jihun Kang, Yunkyung Kim, Taek Yong Ko; Kosin Med J. 2024;39(3):160-168. Published online September 23, 2024; DOI: https://doi.org/10.7180/kmj.24.127

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Traditional hyperthermia involves increasing the temperature at the tumor site to above 39 ℃, inducing death in cancer cells. Although hyperthermia is an effective cancer treatment, its clinical application has decreased due to potential complications, including damage to surrounding normal tissue. In recent years, modulated electro-hyperthermia (mEHT) has emerged as an effective and safe treatment modality. mEHT selectively heats tumor cells to 42–43 °C, while reducing the average temperature in the treatment area, including the surrounding normal tissue, compared to conventional methods. Additionally, mEHT may be used in combination with systemic chemotherapy and radiation therapy in tumor treatment, providing a synergistic effect to increase efficacy. As chemotherapy and radiation therapy technologies advance, the application of combined mEHT may improve clinical outcomes. In this study, we review and discuss reports on the clinical outcomes of mEHT combined with chemotherapy and/or radiation therapy, which are established anticancer treatments.

Citations

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An integrative naturopathic oncology approach in metastatic malignant melanoma: two case reports
Sara Izadi-Najafabadi, Sydney Moffatt, Mackenzie Neufeld, Gurdev Parmar
Frontiers in Oncology.2026;[Epub] CrossRef
Advances and applications of hyperthermia in tumor therapy: Mechanisms, techniques, and clinical integration
Cuihua Gu, Jinzhong Zhang, Wenhua Gao, Jisong Wang, Kun Mou, Xuequn Zhang, Jiude Qi
International Communications in Heat and Mass Transfer.2025; 164: 108895. CrossRef

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