Kosin Medical Journal

Clinical features in patients with thyroid eye disease according to seropositivity for anti-acetylcholine receptor antibodies: Jun Young Lee, Hee-Young Choi, Hyeshin Jeon; Received February 12, 2026 Accepted June 11, 2026 Published online July 6, 2026; DOI: https://doi.org/10.7180/kmj.26.155 [Epub ahead of print]

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Abstract PDF PubReader ePub: Background
Thyroid eye disease (TED) is an autoimmune disorder associated with thyroid-related antigens. Myasthenia gravis (MG) is characterized by impaired neuromuscular transmission caused by an autoimmune response against acetylcholine receptors (AChRs). Because both diseases can present with ocular symptoms, their differential diagnosis can be challenging. This study compared the clinical features of patients with TED according to anti-AChR antibody seropositivity.
Methods
The medical records of patients diagnosed with TED who underwent anti-AChR antibody testing were retrospectively reviewed. Patients were classified into seropositive and seronegative groups according to anti-AChR antibody status. Clinical findings, including eyelid abnormalities, strabismus, and extraocular movement limitations, were compared between the groups.
Results
Seventy-four patients, including 31 male patients (41.9%), were included in the study, and the mean age was 49.9±16.7 years. Eight patients (10.8%) were classified into the seropositive group. Asymmetric exophthalmos was observed in 18 patients (27.7%). Eyelid abnormalities were identified in 37 patients (50.0%), including lid retraction in 22 (29.7%), lid lag in nine (12.2%), and ptosis in 15 (20.3%). Ptosis was more common in the seropositive group than in the seronegative group (50.0% vs. 16.7%, p=0.048). Strabismus was identified in 47 patients (63.5%); vertical strabismus was the most frequent type (51.4%), followed by combined vertical and horizontal strabismus (28.4%), exotropia (20.3%), and esotropia (20.3%). Exotropia (50.0% vs. 16.7%, p=0.048) and adduction limitation (50.0% vs. 10.6%, p=0.014) were significantly more frequent in the seropositive group.
Conclusions
Ptosis, exotropia, and adduction limitation were more frequent in patients with anti-AChR antibody-positive TED. The presence of these findings may warrant further evaluation for coexisting ocular MG.

Stereopsis and clinical features of esotropia patients accompanied by congenital mild ptosis: Heeyoung Choi, Su-Jin Kim, Seung Ahn Yang, Kwang Eon Han; Kosin Med J. 2024;39(4):259-264. Published online December 3, 2024; DOI: https://doi.org/10.7180/kmj.24.123

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Background
To evaluate binocular function and clinical features in patients with esotropia (ET) accompanied by congenital ptosis.
Methods
Clinical records of 44 ET patients with congenital ptosis (ET-ptosis group) and 71 age-matched ET patients without ptosis (ET only group) who presented for eye examination between January 2016 and December 2021 were retrospectively reviewed. Best-corrected visual acuity (BCVA), magnitude of esodeviation and stereopsis at the first visit were reviewed. Stereopsis and other clinical features of the two groups were compared.
Results
The mean (±standard deviation) age of overall patients was 5.7 (±1.9) years. The margin reflex distance 1 (MRD1) of patients with ptosis was greater than 0 but less than or equal to 2, indicating that mild ptosis was included. There was no significant difference in the distribution of age, sex, spherical equivalent refractive errors, BCVA, or magnitude of ET (at distance or near) between the two groups (all p>0.05). Furthermore, stereopsis and the number of patients with amblyopia did not differ significantly between the two groups. The magnitudes of esodeviation, near stereopsis and BCVA did not differ significantly between the 0Conclusions
In patients with ET and congenital mild ptosis, stereopsis and visual acuity were not different from those in ET only patients. The presence of coexisting mild ptosis might not have a further deleterious impact on binocular function in ET patients.

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Congenital mild ptosis might not influence visual function in esotropia patients
Chang Zoo Kim
Kosin Medical Journal.2024; 39(4): 227. CrossRef

Disseminated Staphylococcus aureus infection and acute bacterial pericarditis: a case report: Su Hyun Bae, Song-Hyun Lee, Joon-Young Choi, Bong-Joon Kim, Soo-Jin Kim, Sung-Il Im, Hyun-Su Kim, Jung-Ho Heo; Kosin Med J. 2023;38(2):134-137. Published online August 16, 2022; DOI: https://doi.org/10.7180/kmj.22.021

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We experienced a case of disseminated Staphylococcus aureus infection with bacterial pericarditis that progressed to septic shock and multiorgan failure despite pericardiocentesis and surgical removal of the original abscess with intensive antibiotic therapy. We report this case because of the patient’s very rare and remarkable echocardiographic findings and highly turbid pericardial effusion.

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Case Report: Acute methicillin-sensitive Staphylococcus aureus pericarditis in a diabetic patient
Daniel J. Lim, Richard Lu, Edwin C. Y. Sng, Felix M. Uy, Wei L. Huang, Siang C. Chai, Anthony Yii, Ing X. Soo, Jenn N. Khoo, X. Ruan
Frontiers in Cardiovascular Medicine.2025;[Epub] CrossRef

Association of Weight Change and Physical Activity with Knee Pain and Health-Related Quality of Life in East Asian Women Aged 50 Years and Older with Knee Osteoarthritis: A Population-Based Study: Chong Bum Chang, Young Choi, Seung Baik Kang, Chin Youb Chung, Moon Seok Park, Kyoung Min Lee; Kosin Med J. 2021;36(2):125-135. Published online December 31, 2021; DOI: https://doi.org/10.7180/kmj.2021.36.2.125

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Abstract PDF PubReader ePub: Objectives
This study aimed to investigate the association of self-reported weight change and physical activity with the level of knee pain and health-related quality of life in East Asian women with knee osteoarthritis using population-based data.
Methods
A total of 564 women (mean age, 68.2 years, standard deviation, 8.9 years) aged 50 years or older with knee osteoarthritis (Kellgren-Lawrence (K-L) grade ≥ 2) were included in the data analyses from the fifth Korea National Health and Nutrition Examination Survey. Data regarding the radiographic grade, self-reported weight change during the past year, physical activity, level of knee pain, and health-related quality of life (EuroQOL five-dimension (EQ-5D) index) were collected. Multiple regression analysis was performed to identify factors significantly associated with the level of knee pain and health-related quality of life in subgroups according to the body mass index (BMI) range (≤ 22.5, between 22.6 and 27.5, and > 27.5 kg/m²).
Results
In the whole group, the level of knee pain was significantly associated with K-L grade (P < 0.001), and EQ-5D was negatively associated with age (P < 0.001), the level of knee pain (P < 0.001), and weekly hours of vigorous-intensity activity (P = 0.026). In the subgroup analysis, weight gain showed significant association with the level of knee pain only in women with 22.5 kg/m² < BMI ≤ 27.5 kg/m² (P = 0.006). Weight gain showed significant association with EQ-5D in women with BMI ≤ 22.5 kg/m² (P = 0.047) whereas weekly hours of moderate-intensity activity was negatively associated with EQ-5D in women with BMI > 27.5 kg/m².
Conclusions
The association of weight change and physical activity with knee pain and health-related quality of life might be different according to BMI ranges. Well-designed interventions to improve both knee pain and health-related quality of life need to be investigated in future studies that would strictly control physical activity, diet, and weight changes.

Endoscopic Removal of Remained Drawstring After Percutaneous Transhepatic Biliary Drainage: Tae Wook Yoon, Geun Yong Jung, Young Jun Park, Jun Young Choi, Jee Hwan Jung, Tae Gyoon Kim; Kosin Med J. 2016;31(2):173-178. Published online January 20, 2016; DOI: https://doi.org/10.7180/kmj.2016.31.2.173

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Abstract PDF PubReader ePub: Abstract
The percutaneous transhepatic biliary drainage (PTBD) is an effective intervention as a palliative therapy for relieving a jaundice and cholangitis. It may be used in place of Endoscopic retrograde cholangiopancreatography (ERCP) in the obstructive biliary disease. Recently, by developing invasive procedures, the incidence of the complications such as bleeding and perforation has been increasing in the diagnosis and treatment of hepatobiliary disease. We report here on a case of remained drawstring after PTBD in a 85-year-old man. The patient was conducted PTBD for relieving a jaundice and cholangitis. And then the patient had complained of abdominal pain constantly. A few days later, we removed PTBD and attempted ERCP for removal of CBD stone. The ERCP showed remained drawstring around ampulla of vater and we removed it by IT knife. The drawstring was successfully removed.

Giant Right Atrial Thrombus associated with Tunneled Cuffed Hemodialysis Catheter: A Case of Successful Treatment with Thrombolytic Agent and Anticoagulant: Young Jin Song, Young-Ki Lee, Sun Ryoung Choi, Ji-Hyun Kim, Sun Woo Kim, Jung-Woo Noh; Kosin Med J. 2013;28(1):61-65. Published online January 19, 2013; DOI: https://doi.org/10.7180/kmj.2013.28.1.61

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Abstract PDF PubReader ePub: There are a variety of tunneled cuffed hemodialysis catheter-related complications including infection, thrombus formation, and catheter dysfunction. Catheter-related thrombus in right atrium is a rare complication and treatment guideline for atrial thrombus does not exist. A 3.0×2.8 cm sized giant atrial thrombus was found in a 35-year-old female hemodialysis patient. She was treated with catheter removal, thrombolysis and anticoagulation therapy. Size of atrial thrombus was gradually decreased and left ventricular systolic function was clearly improved after treatment. We experienced and reported a case of giant right atrial thrombus associated with tunneled cuffed hemodialysis catheter that was successful treated with thrombolytic agent and anticoagulant.

Variant Angina Associated with Migrating Spontaneous Occlulsive Vasospasm of Right Coronary Artery: Joung Boom Hong, Jin Her, Jin Hyuck Cho, Park Min Gyu, Young Hee Ham, Sung Gu Jung, Su Hyung Kim, Jae Young Choi; Kosin Med J. 2011;26(2):203-208. Published online December 1, 2011

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Two Cases of Concurrent Papillary and Follicular Carcinoma of The Same Thyroid Lobe: Kyung Won Seo, Jae Young Choi, Jeong Hoon Kim; Kosin Med J. 2008;23(4):271-274. Published online December 31, 2008

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Analyses of Central Neck Lymph Node Metastasis from Papillary Thyroid Cancers: Jae Young Choi; Kosin Med J. 2007;22(2):181-185. Published online December 31, 2007

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The Effect of Asiaticoside on the Improvement of Lip: Kee Suck Suh, Jin Woo Lee, Soo Young Choi, Sang Tae Kim; Kosin Med J. 2007;22(1):220-231. Published online June 30, 2007

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A case of nonrecurrent laryngeal nerve: Jae Young Choi, Ju Won Yoon, Jeong Hoon Kim; Kosin Med J. 2007;22(1):259-261. Published online June 30, 2007

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A Case of Cutaneous Sarcoidosis in Surgical Scars: Kee Suck Suh, Hyoe Jin Roh, Soo Young Choi, Young Seung Jeon, Hyung Jun Sim, Sang Tae Kim; Kosin Med J. 2006;21(1):23-26.

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