Kosin Medical Journal

Review articles

Clinical applications and advancements in noninvasive prenatal diagnosis: Sul Lee, Jin Hyuk Choi, Jong Hyouk Yun, Su Hwan Kang, Jesang Yu, Jihun Kang, Chang Zoo Kim, Taek Yong Ko, Hanggoo Yun; Kosin Med J. 2025;40(2):106-115. Published online June 30, 2025; DOI: https://doi.org/10.7180/kmj.25.118

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Abstract PDF PubReader ePub: Noninvasive prenatal testing (NIPT) is widely performed and enables the detection of fetal chromosomal abnormalities through the analysis of cell-free fetal DNA in maternal blood. Since its introduction in 2011, NIPT has demonstrated high sensitivity and specificity for common trisomies (trisomy 21, trisomy 18, trisomy 13), and its scope has rapidly expanded to include sex chromosome aneuploidies, microdeletion syndromes, and single-gene disorders. However, the widespread adoption of NIPT has brought new challenges, including technical limitations (e.g., low fetal fraction, placental mosaicism), interpretation of variants of uncertain significance, and ethical concerns related to over-screening and patient anxiety. This review summarizes the historical evolution, technical advances, clinical applications, limitations, and future perspectives of NIPT, emphasizing the need for balanced clinical implementation and ongoing innovation.

Current understanding of modulated electro-hyperthermia in cancer treatment: Sungmin Kim, Jesang Yu, Jihun Kang, Yunkyung Kim, Taek Yong Ko; Kosin Med J. 2024;39(3):160-168. Published online September 23, 2024; DOI: https://doi.org/10.7180/kmj.24.127

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Traditional hyperthermia involves increasing the temperature at the tumor site to above 39 ℃, inducing death in cancer cells. Although hyperthermia is an effective cancer treatment, its clinical application has decreased due to potential complications, including damage to surrounding normal tissue. In recent years, modulated electro-hyperthermia (mEHT) has emerged as an effective and safe treatment modality. mEHT selectively heats tumor cells to 42–43 °C, while reducing the average temperature in the treatment area, including the surrounding normal tissue, compared to conventional methods. Additionally, mEHT may be used in combination with systemic chemotherapy and radiation therapy in tumor treatment, providing a synergistic effect to increase efficacy. As chemotherapy and radiation therapy technologies advance, the application of combined mEHT may improve clinical outcomes. In this study, we review and discuss reports on the clinical outcomes of mEHT combined with chemotherapy and/or radiation therapy, which are established anticancer treatments.

Citations

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Advances and applications of hyperthermia in tumor therapy: Mechanisms, techniques, and clinical integration
Cuihua Gu, Jinzhong Zhang, Wenhua Gao, Jisong Wang, Kun Mou, Xuequn Zhang, Jiude Qi
International Communications in Heat and Mass Transfer.2025; 164: 108895. CrossRef

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