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From articles published since 2012.
- Effects of L-ascorbic acid on the production of pro-inflammatory and anti-inflammatory cytokines in C57BL/6 mouse splenocytes
- Eun Hee Kong, Sun Young Ma, Jee Yeong Jeong, Kwang Hyuk Kim
- Kosin Med J. 2015;30(1):41-49. Published online January 20, 2015
- DOI: https://doi.org/10.7180/kmj.2015.30.1.41
- 2,138 View
- 23 Download
- 20 Citations
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Abstract Objective The imbalance between pro-inflammatory and anti-inflammatory cytokines may underlie different pain states. Although ascorbic acid is the most important physiological antioxidant that affects host defense mechanisms and immune homeostasis, there is limited information on the effects of ascorbic acid on the production of cytokines.
Methods In this study, we investigated the in vitro effect of L-ascorbic acid (AA) on the production of pro-inflammatory and anti-inflammatory cytokines by stimulating C57BL/6 mouse splenocytes with the polyclonal activators lipopolysaccharide or concanavalin A.
Results AA significantly downregulated the expression of IL-6, IL-12, and TNF-α at 48 h and 72 h in mouse splenocytes treated with a combination of polyclonal activators and AA. AA treatment also resulted in upregulation of IL-4 and IL-10 at 72 h. These findings demonstrated that AA significantly potentiated production of anti-inflammatory cytokines whereas there was an inverse association between AA and expression of pro-inflammatory cytokines in mouse splenocytes.
Conclusion AA may have potential applications in the reduction of inflammatory pain because of its function in modulating the production of cytokines. However, further in vivo investigations are necessary to elucidate the mechanisms involved.
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- In-vitro administration of vitamin C solution induces multiple cellular mechanisms in common carp brain cells and carp-derived leukocytes, resisting infection by Koi herpesvirus
Ehdaa Eltayeb Eltigani Abdelsalam, Zuzana Bláhová, Veronika Piačková
Aquaculture.2025; 595: 741572. CrossRef - Interleukin-8 and neutrophil extracellular traps in children with lupus nephritis and vitamin C deficiency
Chanunya Santiworakul, Wilasinee Saisorn, Nuanpan Siripen, Asada Leelahavanichkul, Pornpimol Rianthavorn
Pediatric Nephrology.2024; 39(4): 1135. CrossRef - Fisetin ameliorates polycystic ovary syndrome in rats via a mechanistic modulation of AMP-activated protein kinase and SIRT1 molecular pathway
Simerjeet Kaur Chahal, Atul Kabra
Naunyn-Schmiedeberg's Archives of Pharmacology.2024;[Epub] CrossRef - Insights into bioactive constituents of onion (Allium cepa L.) waste: a comparative metabolomics study enhanced by chemometric tools
Mariam M. Elattar, Hala M. Hammoda, Doaa A. Ghareeb, Shaymaa A. Abdulmalek, Fatma. A. Abdelrahim, Inas A. K. Seif, Hend M. Dawood, Reham S. Darwish
BMC Complementary Medicine and Therapies.2024;[Epub] CrossRef - The effect of vitamin C on the recovery of activity and survival of autografted ovaries through inhibition of oxidation and inflammation
Maedeh Talesh Sasani, Monireh Mahmoodi, Malek Soleimani Mehranjani
Tissue and Cell.2024; 91: 102564. CrossRef - Antioxidant Activity, Stability in Aqueous Medium and Molecular Docking/Dynamics Study of 6-Amino- and N-Methyl-6-amino-L-ascorbic Acid
Lara Saftić Martinović, Nada Birkic, Vedran Miletić, Roberto Antolović, Danijela Štanfel, Karlo Wittine
International Journal of Molecular Sciences.2023; 24(2): 1410. CrossRef - Anticancer Activity of Mineral-Supplemented Organically Cultivated Carrot on HT-29 Cells and Its Anti-Inflammatory Effect on Mice Splenocytes
Yanni Pan, Yeon-Jun Lee, Sin-Il Sin, Seung-Hwan Park, Kun-Young Park
Applied Sciences.2023; 13(16): 9209. CrossRef - Sitagliptin Attenuates the Cognitive Deficits in L-Methionine-Induced Vascular Dementia in Rats
Suzan A. Khodir, Manar A. Faried, Huda I. Abd-Elhafiz, Eman M. Sweed, Krzysztof Siemianowicz
BioMed Research International.2022; 2022: 1. CrossRef - Combination Treatment of Omega-3 Fatty Acids and Vitamin C Exhibited Promising Therapeutic Effect against Oxidative Impairment of the Liver in Methotrexate-Intoxicated Mice
Mohammed Alorabi, Doha Saad Mohammed, Gomaa Mostafa-Hedeab, Suzy A. El-Sherbeni, Walaa A. Negm, Ali Ismail A. Mohammed, Hayder M. Al-kuraishy, Nani Nasreldin, Saqer S. Alotaibi, Bashir Lawal, Gaber El-Saber Batiha, Carlos Adam Conte-Junior, Valeria Pasciu
BioMed Research International.2022; 2022: 1. CrossRef - STAT3 inhibition decreases ATP-induced MUC8 gene expression in human airway epithelial cells
Cheol Hong Kim, Kyoung Seob Song
Kosin Medical Journal.2022; 37(2): 134. CrossRef - Critical review on the immunomodulatory activities of carrot’s β-carotene and other bioactive compounds
Gemala Anjani, Fitriyono Ayustaningwarno, Rafika Eviana
Journal of Functional Foods.2022; 99: 105303. CrossRef - Antioxidative and Anti-Inflammatory Activity of Ascorbic Acid
Agnieszka Gęgotek, Elżbieta Skrzydlewska
Antioxidants.2022; 11(10): 1993. CrossRef - The Effect of Ascorbic Acid on Interleukin-10 and Tumor Necrosis Factor-α Cytokines in Rattus norvegicus with Endometritis
Muhammad Oky Prabudi, M. F. G. Siregar, I. P. A. Nasution, S. Ilyas
Open Access Macedonian Journal of Medical Sciences.2021; 9(A): 798. CrossRef - Effect of Ascorbic Acid on Differentiation, Secretome and Stemness of Stem Cells from Human Exfoliated Deciduous Tooth (SHEDs)
Shilpa Bhandi, Ahmed Alkahtani, Mohammed Mashyakhy, Abdulaziz S. Abumelha, Nassreen Hassan Mohammad Albar, Apathsakayan Renugalakshmi, Mazen F. Alkahtany, Ali Robaian, Asma Saleh Almeslet, Vikrant R. Patil, Saranya Varadarajan, Thodur Madapusi Balaji, Rod
Journal of Personalized Medicine.2021; 11(7): 589. CrossRef - Development of a novel in vitro insulin resistance model in primary human tenocytes for diabetic tendinopathy research
Hui Yee Tan, Sik Loo Tan, Seow Hui Teo, Margaret M. Roebuck, Simon P. Frostick, Tunku Kamarul
PeerJ.2020; 8: e8740. CrossRef Active Cousinia thomsonii Extracts Modulate Expression of Crucial Proinflammatory Mediators/Cytokines and NFκB Cascade in Lipopolysaccharide-Induced Albino Wistar Rat Model
Khalid Bashir Dar, Ishfaq Shafi Khan, Shajrul Amin, Aijaz Hassan Ganie, Aashiq Hussain Bhat, Showkat Ahmad Dar, Bilal Ahmad Reshi, Showkat Ahmad Ganie
Journal of Inflammation Research.2020; Volume 13: 829. CrossRef- The potential cytoprotective effect of Vitamin C and Vitamin E on monosodium glutamate-induced testicular toxicity in rats
Safaa Mohamed El Kotb, Dalia El-sayed El-ghazouly, Omnia Ameen
Alexandria Journal of Medicine.2020; 56(1): 134. CrossRef - Combination of ascorbic acid and calcitriol attenuates chronic asthma disease by reductions in oxidative stress and inflammation
Farzaneh Kianian, Seyed Morteza Karimian, Mehri Kadkhodaee, Nasrin Takzaree, Behjat Seifi, Soheila Adeli, Elham Harati, Hamid Reza Sadeghipour
Respiratory Physiology & Neurobiology.2019; 270: 103265. CrossRef - Evaluation of Ascorbic Acid or Curcumin Formulated in a Solid Dispersion on Salmonella Enteritidis Infection and Intestinal Integrity in Broiler Chickens
Daniel Hernandez-Patlan, Bruno Solis-Cruz, Karine P. Pontin, Juan D. Latorre, Xochitl Hernandez-Velasco, Ruben Merino-Guzman, Abraham Mendez-Albores, Billy M. Hargis, Raquel Lopez-Arellano, Guillermo Tellez-Isaias
Pathogens.2019; 8(4): 229. CrossRef - Amelioration ofEscherichia coli‐induced endometritis with ascorbic acid in non‐pregnant mouse models
Enitome Evi Bafor, Ikechukwu Onwukpa, Anne Oghenekevwe Itemire, Osemelomen Omoruyi, Ejiroghene Eferoba‐Idio, Kevin Odega, Osas Jim Eghianruwa
American Journal of Reproductive Immunology.2018;[Epub] CrossRef
- In-vitro administration of vitamin C solution induces multiple cellular mechanisms in common carp brain cells and carp-derived leukocytes, resisting infection by Koi herpesvirus
- Aging of the respiratory system
- Seung Hun Lee, Su Jin Yim, Ho Cheol Kim
- Kosin Med J. 2016;31(1):11-18. Published online February 4, 2016
- DOI: https://doi.org/10.7180/kmj.2016.31.1.11
- 4,195 View
- 282 Download
- 16 Citations
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Abstract
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Abstract Changes in the respiratory system caused by aging generally include structural changes in the thoracic cage and lung parenchyma, abnormal findings on lung function tests, ventilation and gas exchange abnormalities, decreased exercise capacity, and reduced respiratory muscle strength. Decreased respiratory system compliance caused by reduced elastic recoil of the lung parenchymaand thoracic cage is related to decreased energy expenditure by the respiratory system. Lung function, as measured by 1-second forced expiratory volume and forced vital capacity (FVC), decreases with age, whereas total lung capacity remains unchanged. FVC decreases because of increased residual volume and diffusion capacity also decreases. Increased physiological dead space and ventilation/perfusion imbalance may reduce blood oxygen levels and increase the alveolar-arterial oxygen difference. More than 20% decrease in diaphragmstrength is thought to beassociated withaging-related muscle atrophy. Ventilation per minute remains unchanged, and blood carbon dioxide concentration does not increase with aging. However, responses to hypoxia and hypercapnia are decreased. Exercise capacity also decreases, and maximum oxygen consumption decreases by >1%/year. Consequence of these changes, many respiratory diseases occur with aging. Thus, it is important to recognize these aging-related respiratory system changes.
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Citations
Citations to this article as recorded by- Cut-off Value of Anthropometric Indices for the Prediction of Pulmonary Function and Risk Factors Among the Chiru Tribe of Manipur
Hosea Thanglen, Urapam Zimik, Ramthar Thanglen
The Oriental Anthropologist: A Bi-annual International Journal of the Science of Man.2024;[Epub] CrossRef - Effects of trunk muscle strength training on lung function in healthy runners
Yuki NAKAI, Yasufumi TAKESHITA
The Journal of Sports Medicine and Physical Fitness.2024;[Epub] CrossRef - Longitudinal Relationship Between Physical Activity Levels and Respiratory Function in Older Individuals : A Longitudinal Study
Makoto Suzuki, Takaaki Ikeda
Journal of Comprehensive Nursing Research and Care.2024;[Epub] CrossRef - Prediction of Lung Function Status Using Handgrip Strength and Anthropometry among the Healthy Malay Population in Malaysia
Mohd Hasni Ja’afar, Rosnah Ismail, Noor Hassim Ismail, Zaleha Md Isa, Azmi Mohd Tamil, Nafiza Mat Nasir, Tengku Saifudin Tengku Ismail, Nurul Hafiza Ab Razak, Najihah Zainol Abidin, MyLinh Duong, Khairul Hazdi Yusof
Healthcare.2023; 11(7): 1056. CrossRef - Activities of Daily Living and Related Factors in Elderly Patients with Pulmonary Disease Preparing for Discharge
Hyunwoo Jeong, Sanghee Kim, Mona Choi, Eui Geum Oh
Korean Journal of Adult Nursing.2022; 34(4): 391. CrossRef - Aging, inflammaging and immunosenescence as risk factors of severe COVID-19
Anteneh Mehari Tizazu, Hylemariam Mihiretie Mengist, Gebreselassie Demeke
Immunity & Ageing.2022;[Epub] CrossRef - Determinants of dynamic inspiratory muscle strength in healthy trained elderly
A Roldán, A Forte, P Monteagudo, A Cordellat, J Monferrer-Marín, C Blasco-Lafarga
Postgraduate Medicine.2021; 133(7): 807. CrossRef - Comparison of Voice-Related Quality of Life for the Elderly with and without Voice Disorders According to Genders by Aging Voice Index-Korean Version
Hwa-Young Pyo, Jae-Yol Lim, Sung-Eun Lim, Seung Jin Lee
Communication Sciences & Disorders.2021; 26(4): 933. CrossRef - Age‐related changes in cerebrovascular health and their effects on neural function and cognition: A comprehensive review
Benjamin Zimmerman, Bart Rypma, Gabriele Gratton, Monica Fabiani
Psychophysiology.2021;[Epub] CrossRef - Yaşlılarda Ortaya Çıkan Fizyolojik Değişiklikler
Ali AĞAR
Ordu Üniversitesi Hemşirelik Çalışmaları Dergisi.2020; 3(3): 347. CrossRef - Perubahan Fungsi Paru Pada Usia Tua
Helmia Hasan, Rena Arusita Maranatha
Jurnal Respirasi.2019; 3(2): 52. CrossRef - Possibilities of modern anesthetic management of laparoscopic cholecystectomy in elderly patients
O. V. Bielykh
Problems of Uninterrupted Medical Training and Science.2019; 2019(2): 84. CrossRef - Beneficial Effects of Inspiratory Muscle Training Combined With Multicomponent Training in Elderly Active Women
Ainoa Roldán, Ana Cordellat, Pablo Monteagudo, Consolación García-Lucerga, Nieves M. Blasco-Lafarga, Mª Carmen Gomez-Cabrera, Cristina Blasco-Lafarga
Research Quarterly for Exercise and Sport.2019; 90(4): 547. CrossRef - Factors Affecting Lung Function: A Review of the Literature
Alejandro Talaminos Barroso, Eduardo Márquez Martín, Laura María Roa Romero, Francisco Ortega Ruiz
Archivos de Bronconeumología (English Edition).2018; 54(6): 327. CrossRef - Factores que afectan a la función pulmonar: una revisión bibliográfica
Alejandro Talaminos Barroso, Eduardo Márquez Martín, Laura María Roa Romero, Francisco Ortega Ruiz
Archivos de Bronconeumología.2018; 54(6): 327. CrossRef - Normal aging: definition and physiologic changes
Chul Ho Chang, Ki-Young Lee, Yon Hee Shim
Journal of the Korean Medical Association.2017; 60(5): 358. CrossRef
- Cut-off Value of Anthropometric Indices for the Prediction of Pulmonary Function and Risk Factors Among the Chiru Tribe of Manipur
- How to write an original article in medicine and medical science
- Gwansuk Kang, Sung Eun Kim
- Kosin Med J. 2022;37(2):96-101. Published online June 24, 2022
- DOI: https://doi.org/10.7180/kmj.22.105
- 4,276 View
- 86 Download
- 10 Citations
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Abstract
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- Excellent research in the fields of medicine and medical science can advance the field and contribute to human health improvement. In this aspect, research is important. However, if researchers do not publish their research, their efforts cannot benefit anyone. To make a difference, researchers must disseminate their results and communicate their opinions. One way to do this is by publishing their research. Therefore, academic writing is an essential skill for researchers. However, preparing a manuscript is not an easy task, and it is difficult to write well. Following a structure may be helpful for researchers. For example, the standard structure of medical and medical science articles includes the following sections: introduction, methods, results, and discussion (IMRAD). The purpose of this review is to present an introduction for researchers, especially novices, on how to write an original article in the field of medicine and medical science. Therefore, we discuss how to prepare and write a research manuscript for publication, using the IMRAD structure. We also included specific tips for writing manuscripts in medicine and medical science.
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Citations
Citations to this article as recorded by- Predicting Safe Liver Resection Volume for Major Hepatectomy Using Artificial Intelligence
Chol Min Kang, Hyung June Ku, Hyung Hwan Moon, Seong-Eun Kim, Ji Hoon Jo, Young Il Choi, Dong Hoon Shin
Journal of Clinical Medicine.2024; 13(2): 381. CrossRef - Changes in parents’ health concerns by post-preterm birth period in South Korea: a cross-sectional study
Yu Jin Jung, Hun Ha Cho
Child Health Nursing Research.2024; 30(2): 118. CrossRef - Long-Term Outcomes and Risk Factors for Lymph Node Metastasis in Siewert Type II/III Early Gastric Cancer
Min Young Son, Dae Hyeon Cho, Sung Eun Kim, Seun Ja Park, Moo In Park, Won Moon, Jae Hyun Kim, Jung Wook Lee, Kyoungwon Jung
The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2024; 24(3): 252. CrossRef - Satellite cell distribution in the medial rectus muscle in cadavers
Chang Zoo Kim, Sang Joon Lee
Kosin Medical Journal.2024; 39(3): 195. CrossRef - Current understanding of modulated electro-hyperthermia in cancer treatment
Sungmin Kim, Jesang Yu, Jihun Kang, Yunkyung Kim, Taek Yong Ko
Kosin Medical Journal.2024; 39(3): 160. CrossRef - Troponin I and D-dimer levels as triaging biomarkers to distinguish acute pulmonary thromboembolism from myocardial infarction
Soo-Jin Kim, Moo Hyun Kim, Kwang Min Lee, Jin Woo Lee, Young Shin Cha, Da Eun Koh, Joo Yeong Hwang, Jong Sung Park
Kosin Medical Journal.2023; 38(4): 252. CrossRef - Prevention of myopia progression using orthokeratology
Stephanie Suzanne S. Garcia, Changzoo Kim
Kosin Medical Journal.2023; 38(4): 231. CrossRef - Basic knowledge of endoscopic retrograde cholangiopancreatography
Jung Wook Lee
Kosin Medical Journal.2023; 38(4): 241. CrossRef - How does quiz activity affect summative assessment outcomes? An analysis of three consecutive years’ data on self-directed learning
Chi Eun Oh, Hyunyong Hwang
Kosin Medical Journal.2022; 37(3): 228. CrossRef - The effects of rebamipide, sucralfate, and rifaximin against inflammation and apoptosis in radiation-induced murine intestinal injury
Won Moon, Sangwook Lim, Yeonsoon Jung, Yuk Moon Heo, Seun Ja Park, Moo In Park, Sung Eun Kim, Jae Hyun Kim, Kyoungwon Jung
Kosin Medical Journal.2022; 37(4): 320. CrossRef
- Predicting Safe Liver Resection Volume for Major Hepatectomy Using Artificial Intelligence
- Ethical issues in clinical research and publication
- Hyoung Shin Lee
- Kosin Med J. 2022;37(4):278-282. Published online December 15, 2022
- DOI: https://doi.org/10.7180/kmj.22.132
- 8,659 View
- 311 Download
- 9 Citations
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Abstract
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- Clinical research including human participants should be based on truth, demonstrate scientific integrity, and follow ethical standards and guidelines to protect study participants. The publication of clinical research should be transparent and adhere to strict criteria for authorship. A thorough understanding and knowledge of ethical issues will limit investigator misconduct in clinical research and publication. In this article, basic ethical issues in clinical research and publication are reviewed and summarized based on recent guidelines.
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Citations
Citations to this article as recorded by- Squamous cell carcinoma of the pancreas with a pancreatic intraductal papillary mucinous neoplasm: a case report
Nam Kyung Lee
Kosin Medical Journal.2024; 39(1): 71. CrossRef - Clinical efficacy and safety of autologous serum intramuscular injection in patients with mild-to-moderate atopic dermatitis: a prospective, open-label, uncontrolled study
Gil-Soon Choi, Jong Bin Park, Young-Ho Kim, Hee-Kyoo Kim
Kosin Medical Journal.2024; 39(1): 51. CrossRef - Surgical management of giant adrenal myelolipoma using a modified Makuuchi incision: a case report
Byeong Jin Kang, Seung Hyeon Kim, Kyoungha Jang, Kyung Hwan Kim, Hong Koo Ha
Kosin Medical Journal.2024; 39(1): 75. CrossRef - Evaluating the Potential of Immersive Virtual Reality-Based Serious Games Interventions for Autism: A Pocket Guide Evaluation Framework
Sara Peretti, Maria Chiara Pino, Federica Caruso, Tania Di Mascio
Education Sciences.2024; 14(4): 377. CrossRef - Informed Consent in Clinical Studies in the Republic of Srpska
Snežana Pantović, Dijana Zrnić
Review of European and Comparative Law.2024;[Epub] CrossRef - Antifungal susceptibility and speciation of Candida isolated from blood at a tertiary care centre
Jagruti Prajapati, Arpita Shah, Hemali Parmar, Bithika Duttaroy
International Journal of Medicine and Medical Research.2024; 10(1): 32. CrossRef - Satellite cell distribution in the medial rectus muscle in cadavers
Chang Zoo Kim, Sang Joon Lee
Kosin Medical Journal.2024; 39(3): 195. CrossRef - Clinical outcomes of prostate artery embolization for management of benign prostate hyperplasia (prostate larger than 100 mL) with or without hematuria
Soodong Kim
Kosin Medical Journal.2023; 38(4): 259. CrossRef - Basic knowledge of endoscopic retrograde cholangiopancreatography
Jung Wook Lee
Kosin Medical Journal.2023; 38(4): 241. CrossRef
- Squamous cell carcinoma of the pancreas with a pancreatic intraductal papillary mucinous neoplasm: a case report
- How to write case reports in medicine
- Sung Il Im
- Kosin Med J. 2022;37(2):102-106. Published online June 24, 2022
- DOI: https://doi.org/10.7180/kmj.22.109
- 3,832 View
- 115 Download
- 7 Citations
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Abstract
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- Medical research has become an important part of providing care to patients. Case reports published in medical journals can communicate information to the medical community about rare or unreported features, conditions, complications, or interventions. Case reports are generally short, focusing on key components such as a summary and introduction, case presentation, and discussion. Authors now have access to free, continuously updated case reports of different types from multiple journals. This review introduces the process and mechanisms for how and when to prepare a case report. We briefly review the editorial process of each of these complementary journals, along with author anecdotes, hoping to inspire authors to write and continue writing case reports; and discusses the essentials of a case report, aiming to provide guidelines for improving medical writing skills.
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Citations
Citations to this article as recorded by- Surgical management of giant adrenal myelolipoma using a modified Makuuchi incision: a case report
Byeong Jin Kang, Seung Hyeon Kim, Kyoungha Jang, Kyung Hwan Kim, Hong Koo Ha
Kosin Medical Journal.2024; 39(1): 75. CrossRef - A rare cause of progressive dysphagia
Jongin Jeon, Sung Eun Kim, Sun-Ju Oh
Clinical Endoscopy.2024; 57(5): 697. CrossRef - A fatal pediatric case of acute fulminant cerebral edema with COVID-19 in Korea: a case report
Minyoung Jung, Chi Eun Oh, Yujin Nam, Dalo Jung, Gyu Min Yeon
Kosin Medical Journal.2024; 39(3): 220. CrossRef - A Case of Early Malignant Change from Neurofibroma to Malignant Peripheral Nerve Sheath Tumor
Poo Reum Kang, Yeong Joon Kim, Sun Ju Oh, Hyoung Shin Lee
Korean Society for Head and Neck Oncology.2023; 39(2): 45. CrossRef - Gastric Adenocarcinoma of Fundic-gland Type Diagnosed and Treated by Endoscopic Mucosal Resection
Sung Eun Kim, Seun Ja Park, Moo In Park, Won Moon, Jae Hyun Kim, Kyoungwon Jung, Bang Ju Kim, Hee Kyung Chang
Journal of Digestive Cancer Research.2023; 11(3): 165. CrossRef - Perioperative cutaneous complications in an elderly patient due to inappropriate use of a forced-air warming device and underbody blanket: a case report
Myounghun Kim, Soo Jee Lee, Beomseok Choi, Geunho Lee, Seunghee Ki
Kosin Medical Journal.2023; 38(4): 288. CrossRef - Selective adjuvant radiation therapy for distant lymph node metastasis in patients with stage 4B epithelial ovarian cancer: a case series
Eun Taeg Kim, Seung Yeon Oh, Sun Young Ma, Tae Hwa Lee, Won Gyu Kim
Kosin Medical Journal.2023; 38(4): 293. CrossRef
- Surgical management of giant adrenal myelolipoma using a modified Makuuchi incision: a case report
- How to conduct well-designed clinical research
- Da Jung Kim, Song Yi Kil, Jongwon Son, Ho Sup Lee
- Kosin Med J. 2022;37(3):187-191. Published online September 27, 2022
- DOI: https://doi.org/10.7180/kmj.22.122
- 3,219 View
- 86 Download
- 6 Citations
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Abstract
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- Clinicians and healthcare decision-makers conduct their clinical practice based on the results of clinical trials. However, some health problems remain unresolved; in such cases, further research is required. To ensure reliable research results, it is important to understand the study design and conduct well-designed clinical trials. Many study designs can be chosen within the two broad categories of observational and interventional. Clinical studies have a variety of designs, including case series, case-control, cross-sectional, and prospective and retrospective cohort studies. Well-designed clinical studies can clarify important differences between treatment options and provide data on long-term drug efficacy and safety. Interpreting the results of clinical trials can be difficult because weaknesses in research design, data collection methods, analytic methods, and reporting can compromise their value and usefulness. However, although randomized controlled trials are limited owing to ethical and practical issues, they are optimal for investigating the effects of therapy and establishing causality. Here we present an overview of different clinical research designs and review their advantages and limitations.
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Citations
Citations to this article as recorded by- Gastric cancer and metabolic syndrome
Hyeong Ho Jo
Kosin Medical Journal.2024; 39(1): 26. CrossRef - Clinical efficacy and safety of autologous serum intramuscular injection in patients with mild-to-moderate atopic dermatitis: a prospective, open-label, uncontrolled study
Gil-Soon Choi, Jong Bin Park, Young-Ho Kim, Hee-Kyoo Kim
Kosin Medical Journal.2024; 39(1): 51. CrossRef - Changes in parents’ health concerns by post-preterm birth period in South Korea: a cross-sectional study
Yu Jin Jung, Hun Ha Cho
Child Health Nursing Research.2024; 30(2): 118. CrossRef - Basic knowledge of endoscopic retrograde cholangiopancreatography
Jung Wook Lee
Kosin Medical Journal.2023; 38(4): 241. CrossRef - Evaluation of automated calibration and quality control processes using the Aptio total laboratory automation system
Namhee Kim, Yein Kim, Jeongeun Park, Jungsoo Choi, Hyunyong Hwang
Kosin Medical Journal.2022; 37(4): 342. CrossRef - The effects of rebamipide, sucralfate, and rifaximin against inflammation and apoptosis in radiation-induced murine intestinal injury
Won Moon, Sangwook Lim, Yeonsoon Jung, Yuk Moon Heo, Seun Ja Park, Moo In Park, Sung Eun Kim, Jae Hyun Kim, Kyoungwon Jung
Kosin Medical Journal.2022; 37(4): 320. CrossRef
- Gastric cancer and metabolic syndrome
- The Roles of Human Endogenous Retroviruses (HERVs) in Inflammation
- Eun-Ji Ko, Hee-Jae Cha
- Kosin Med J. 2021;36(2):69-78. Published online December 31, 2021
- DOI: https://doi.org/10.7180/kmj.2021.36.2.69
- 3,180 View
- 76 Download
- 6 Citations
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Abstract
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Human endogenous retroviruses (HERVs) are ancient, currently inactive, and non-infectious due to recombination, deletions, and mutations in the host genome. However, HERV-derived elements are involved in physiological phenomena including inflammatory response. In recent studies, HERV-derived elements were involved directly in various inflammatory diseases including autoimmune diseases such as rheumatoid arthritis (RA), multiple sclerosis, amyotrophic lateral sclerosis (ALS), and Sjogren’s syndrome. Regarding the involvement of HERV-derived elements in inflammation, two possible mechanisms have been proposed. First, HERV-derived elements cause nonspecific innate immune processes. Second, HERV-derived RNA or proteins might stimulate selective signaling mechanisms. However, it is unknown how silent HERV elements are activated in the inflammatory response and what factors and signaling mechanisms are involved with HERV-derived elements. In this review, we introduce HERV-related autoimmune diseases and propose the possible action mechanisms of HERV-derived elements in the inflammatory response at the molecular level.
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Citations
Citations to this article as recorded by- Correlation analysis of cancer stem cell marker CD133 and human endogenous retrovirus (HERV)-K env in SKOV3 ovarian cancer cells
Do-Ye Kim, Heungyeol Kim, Eun-Ji Ko, Suk Bong Koh, Hongbae Kim, Ji Young Lee, Chul Min Lee, Wan Kyu Eo, Ki Hyung Kim, Hee-Jae Cha
Genes & Genomics.2024; 46(4): 511. CrossRef - The Humoral Immune Response against Human Endogenous Retroviruses in Celiac Disease: A Case–Control Study
Marco Bo, Roberto Manetti, Maria Luigia Biggio, Leonardo A. Sechi
Biomedicines.2024; 12(8): 1811. CrossRef - Transcriptome analysis of the effect of HERV-K env gene knockout in ovarian cancer cell lines
Eun-Ji Ko, Dong Soo Suh, Hongbae Kim, Ji Young Lee, Wan Kyu Eo, Heungyeol Kim, Ki Hyung Kim, Hee-Jae Cha
Genes & Genomics.2024;[Epub] CrossRef - The Role of Human Endogenous Retrovirus (HERV)-K119 env in THP-1 Monocytic Cell Differentiation
Eun-Ji Ko, Min-Hye Kim, Do-Ye Kim, Hyojin An, Sun-Hee Leem, Yung Hyun Choi, Heui-Soo Kim, Hee-Jae Cha
International Journal of Molecular Sciences.2023; 24(21): 15566. CrossRef - Effect of human endogenous retrovirus-K env gene knockout on proliferation of ovarian cancer cells
Eun-Ji Ko, Eun Taeg Kim, Heungyeol Kim, Chul Min Lee, Suk Bong Koh, Wan Kyu Eo, Hongbae Kim, Young Lim Oh, Mee Sun Ock, Ki Hyung Kim, Hee-Jae Cha
Genes & Genomics.2022; 44(9): 1091. CrossRef - A Systems Biology Approach on the Regulatory Footprint of Human Endogenous Retroviruses (HERVs)
Georgios S. Markopoulos
Diseases.2022; 10(4): 98. CrossRef
- Correlation analysis of cancer stem cell marker CD133 and human endogenous retrovirus (HERV)-K env in SKOV3 ovarian cancer cells
- New approach to learning medical procedures using a smartphone and the Moodle platform to facilitate assessments and written feedback
- Sang-Shin Lee, Haeyoung Lee, Hyunyong Hwang
- Kosin Med J. 2022;37(1):75-82. Published online March 25, 2022
- DOI: https://doi.org/10.7180/kmj.22.010
- 4,013 View
- 105 Download
- 5 Citations
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Abstract
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- Background
To overcome communication obstacles between medical students and trainers, we designed serial learning activities utilizing a smartphone and web-based instruction (WBI) on the Moodle platform to provide clear and retrievable trainer feedback to students on an objective structured clinical examination (OSCE) item.
Methods
We evaluated students’ learning achievement and satisfaction with the new learning tool. A total of 80 fourth-year medical students participated. They installed the Moodle app (the WBI platform) on their smartphones and practiced an endotracheal suction procedure on a medical simulation mannequin while being evaluated by a trainer regarding competence in clinical skills on the smartphone app. Students’ competency was evaluated by comparing the scores between the formative assessment and the summative assessment. The degree of satisfaction and usefulness for the smartphone and WBI system were analyzed.
Results
The means (standard deviations, SDs) of the formative and summative assessments were 8.80 (2.53) and 14.24 (1.97) out of a total of 17 points, respectively, reflecting a statistically significant difference (P<0.05). The degree of satisfaction and perceived usefulness of the smartphone app and WBI system were excellent, with means (SDs) of 4.60 (0.58), and 4.60 (0.65), respectively.
Conclusion
We believe that the learning process using a smartphone and the Moodle platform offers good guidance for OSCE skill development because trainers’ written feedback is recorded online and is retrievable at all times, enabling students to build and maintain competency through frequent feedback review. -
Citations
Citations to this article as recorded by- Faculty development: the need to ensure educational excellence and health care quality
Hyekyung Shin, Min-Jeong Kim
Kosin Medical Journal.2023; 38(1): 4. CrossRef - Is It Time to Revise the Competency-Based Assessment? Objective Structured Clinical Examination and Technology Integration
Haniye Mastour, Nazanin Shamaeian Razavi
Shiraz E-Medical Journal.2023;[Epub] CrossRef - Do we need Moodle in medical education? A review of its impact and utility
Seri Jeong, Hyunyong Hwang
Kosin Medical Journal.2023; 38(3): 159. CrossRef - The effectiveness of Moodle's “Lesson” feature in pre-learning about arterial puncture and blood transfusion procedures
Haeyoung Lee, Sang-Shin Lee, Hyunyong Hwang
Kosin Medical Journal.2023; 38(4): 278. CrossRef - How does quiz activity affect summative assessment outcomes? An analysis of three consecutive years’ data on self-directed learning
Chi Eun Oh, Hyunyong Hwang
Kosin Medical Journal.2022; 37(3): 228. CrossRef
- Faculty development: the need to ensure educational excellence and health care quality
- The Management of Foreign Body Sensation in the Throat after Stroke by Trigger Point Injection on Posterior Belly of Digastric Muscles
- Howard Kim, Hoe Saeng Yang, Ji Hwan Cheon, Ki Hong Won
- Kosin Med J. 2021;36(1):34-39. Published online June 30, 2021
- DOI: https://doi.org/10.7180/kmj.2021.36.1.34
- 1,992 View
- 15 Download
- 4 Citations
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Abstract
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Foreign body (FB) sensation in the throat is often a common symptom encountered in clinical practice. FB sensation in throat has numerous causes mainly caused by reflex diseases such as laryngopharyngeal reflux. Its treatment has been focused on organic problems or hysteria while musculoskeletal problem has been neglected. We hereby report a patient with dysphagia and complaint of FB sensation in the throat after nasogastric tube removal. It was relieved by trigger point injection on the posterior belly of digastric muscles.
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Citations
Citations to this article as recorded by- Relación entre los umbrales de dolor a la presión perilaríngeos y la severidad de los síntomas de disconfort del tracto vocal en mujeres vocalmente sanas
Christopher Fuentes Aracena, Christopher Biermann Orizola , Constanza Torres Yáñez
Revista de Investigación en Logopedia.2024; 14(1): e87660. CrossRef - Efectos de la termoterapia asociada a electroestimulación sobre los umbrales de dolor a la presión perilaríngeos y los síntomas de disconfort del tracto vocal en mujeres vocalmente sanas
Christopher Fuentes Aracena, Christopher Biermann Orizola , Constanza Torres Yáñez
Revista de Investigación en Logopedia.2024; 14(2): e90514. CrossRef - Odinofonía: una actualización clínica
Christopher Hernán Fuentes Aracena
Revista de Investigación e Innovación en Ciencias de la Salud.2023; 5(1): 191. CrossRef - Differences between the Perilaryngeal Pressure Pain Thresholds in Asymptomatic Women, Women With Bruxism, and Women With Odynophonia
Christopher Fuentes, Sebastián Castañón, Lylia Roldán
Journal of Voice.2023;[Epub] CrossRef
- Relación entre los umbrales de dolor a la presión perilaríngeos y la severidad de los síntomas de disconfort del tracto vocal en mujeres vocalmente sanas
- Antinociceptive Effect of BPC-157 in the Formalin-induced Pain Model
- Sang Yoong Park, So Ron Choi, Jeong Ho Kim, Seung Cheol Lee, Seong Yeop Jeong, Joon Ho Jeong, Tae Young Lee
- Kosin Med J. 2021;36(1):1-13. Published online June 30, 2021
- DOI: https://doi.org/10.7180/kmj.2021.36.1.1
- 4,433 View
- 24 Download
- 4 Citations
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Abstract
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Objectives Body protective compound-157 (BPC-157) is a stable gastric pentadecapeptide that has been effective in trials aiming to increase wound healing capabilities and decrease inflammatory cell influx, including studies on the healing of muscles and tendons. There are no studies about the effect of BPC-157 on pain transmission via nociception. This study examined the antinociceptive effects of BPC-157 using formalin tests and immunohistochemistry.
Methods Rats were randomly divided into the control, morphine and BPC-157 groups. Pain behavior was quantified periodically at 5- and 35- min intervals (representative values of phases 1 and 2) by counting the number of flinches exhibited by the injected paw after injection. The dorsal root ganglia (DRG) and spinal cords (SC) were collected, and then, the number of cytokine-positive cells was determined via immunostaining.
Results BPC-157 dose-dependently decreased the number of flinches during phase 1 but did not decrease the number of flinches during phase 2. During phase 1, interleukin-1β (IL-1β) in the DRG tissue was significantly different in the morphine, 10 μg/kg BPC-157, and 20 μg/kg BPC-157 groups. During phase 2, statistical significance was achieved in the DRG tissue in the morphine, 20 μg/kg BPC-157, and 40 μg/kg BPC-157 groups. During phase 1, interleukin-6 was significantly different in the DRG tissue in the morphine group and the SC tissue in the 10 μg/kg BPC-157 group. During phase 2, statistical significance was achieved in the morphine group and the BPC-157 20 μg/kg group in both the DRG and SC tissues. There were no significant differences in tumor necrosis factor-α between the DRG and SC tissues.
Conclusions BPC-157 was effective during phase 1 but not during phase 2, as determined by the formalin test. BPC-157 decreased the expression of IL-1β in the DRG tissue in phases 1 and 2.
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Citations
Citations to this article as recorded by- Stable Gastric Pentadecapeptide BPC 157 May Recover Brain–Gut Axis and Gut–Brain Axis Function
Predrag Sikiric, Slaven Gojkovic, Ivan Krezic, Ivan Maria Smoday, Luka Kalogjera, Helena Zizek, Katarina Oroz, Hrvoje Vranes, Vlasta Vukovic, May Labidi, Sanja Strbe, Lidija Baketic Oreskovic, Marko Sever, Marijan Tepes, Mario Knezevic, Ivan Barisic, Vlad
Pharmaceuticals.2023; 16(5): 676. CrossRef - The anti-nociceptive effect of BPC-157 on the incisional pain model in rats
Young-Hoon Jung, Haekyu Kim, Hyaejin Kim, Eunsoo Kim, Jiseok Baik, Hyunjong Kang
Journal of Dental Anesthesia and Pain Medicine.2022; 22(2): 97. CrossRef - Stable Gastric Pentadecapeptide BPC 157 as Useful Cytoprotective Peptide Therapy in the Heart Disturbances, Myocardial Infarction, Heart Failure, Pulmonary Hypertension, Arrhythmias, and Thrombosis Presentation
Predrag Sikiric, Mario Udovicic, Ivan Barisic, Diana Balenovic, Gordana Zivanovic Posilovic, Dean Strinic, Sandra Uzun, Suncana Sikiric, Ivan Krezic, Helena Zizek, Haidi Yago, Slaven Gojkovic, Ivan Maria Smoday, Luka Kalogjera, Hrvoje Vranes, Marija Sola,
Biomedicines.2022; 10(11): 2696. CrossRef - Stable Gastric Pentadecapeptide BPC 157 and Striated, Smooth, and Heart Muscle
Mario Staresinic, Mladen Japjec, Hrvoje Vranes, Andreja Prtoric, Helena Zizek, Ivan Krezic, Slaven Gojkovic, Ivan Maria Smoday, Katarina Oroz, Eva Staresinic, Vilim Dretar, Haidi Yago, Marija Milavic, Suncana Sikiric, Eva Lovric, Lovorka Batelja Vuletic,
Biomedicines.2022; 10(12): 3221. CrossRef
- Stable Gastric Pentadecapeptide BPC 157 May Recover Brain–Gut Axis and Gut–Brain Axis Function
- Spontaneous Coronary Artery Dissection in a female patient with fragile X syndrome
- Hyun-Young Park, Jin-Man Cho, Dong-Hee Kim, Chang-Bum Park, Chong-Jin Kim
- Kosin Med J. 2017;32(2):240-243. Published online January 19, 2017
- DOI: https://doi.org/10.7180/kmj.2017.32.2.240
- 1,707 View
- 7 Download
- 4 Citations
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Abstract
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We report a case of Spontaneous coronary artery dissection associated with fragile X syndrome. The relationship between fragile X syndrome and Spontaneous coronary artery dissection is unclear. However, More research will need about the causes and treatment of Spontaneous coronary artery dissection.
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Citations
Citations to this article as recorded by- Hypermobile Ehlers-Danlos syndrome (hEDS) phenotype in fragile X premutation carriers: case series
Nattaporn Tassanakijpanich, Forrest J McKenzie, Yingratana A McLennan, Elisabeth Makhoul, Flora Tassone, Mittal J Jasoliya, Christopher Romney, Ignacio Cortina Petrasic, Kaye Napalinga, Caroline B Buchanan, Paul Hagerman, Randi Hagerman, Emily L Casanova
Journal of Medical Genetics.2022; 59(7): 687. CrossRef - Exploring the Genetic Architecture of Spontaneous Coronary Artery Dissection Using Whole-Genome Sequencing
Ingrid Tarr, Stephanie Hesselson, Siiri E. Iismaa, Emma Rath, Steven Monger, Michael Troup, Ketan Mishra, Claire M.Y. Wong, Pei-Chen Hsu, Keerat Junday, David T. Humphreys, David Adlam, Tom R. Webb, Anna A. Baranowska-Clarke, Stephen E. Hamby, Keren J. Ca
Circulation: Genomic and Precision Medicine.2022;[Epub] CrossRef - Spontaneous Coronary Artery Dissection in Females With the Fragile X FMR1 Premutation
Forrest J. McKenzie, Nattaporn Tassanakijpanich, Kelly C. Epps, S. Kimara March, Randi J. Hagerman
JACC: Case Reports.2020; 2(1): 40. CrossRef - Cardiovascular Problems in the Fragile X Premutation
Nattaporn Tassanakijpanich, Jonathan Cohen, Rashelle Cohen, Uma N. Srivatsa, Randi J. Hagerman
Frontiers in Genetics.2020;[Epub] CrossRef
- Hypermobile Ehlers-Danlos syndrome (hEDS) phenotype in fragile X premutation carriers: case series
A Computer-Assisted, Real-Time Feedback System for Medical Students as a Tool for Web-Based Learning - Hyunyong Hwang
- Kosin Med J. 2016;31(2):134-145. Published online January 20, 2016
- DOI: https://doi.org/10.7180/kmj.2016.31.2.134
- 1,595 View
- 5 Download
- 4 Citations
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Abstract
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Abstract Objectives Medical students sometimes do not receive proper feedback from their instructors. This study evaluated a newly developed automated and personalized real-time feedback system intended to address this issue.
Methods Third- and fourth-year medical students participated in quizzes focusing on 17 learning objectives and a five-scale survey that queried their prior knowledge related to blood transfusions. Immediately after completing the quizzes, the students received automated and personalized, real-time feedback and were instructed to take part in self-directed learning. This activity was followed by a final quiz. After completion of the final quiz, the students responded to the five-scale survey that probed the usefulness of and satisfaction with the automated, personalized, real-time feedback system.
Results Eighty students took part in this study. The third-year group had a higher score for prior knowledge and also on the first quiz (P= 0.008, P= 0.046, respectively). There was no significant difference in final quiz scores between the third- and fourth-year groups (P= 0.633). The scores for usefulness of and satisfaction with the automated, real-time feedback system were 4.45 and 4.34, and 4.55 and 4.40 in the third- and fourth-year students, respectively.
Conclusions The automated, personalized, real-time feedback system provided timely and effective feedback for medical students and was helpful for their self-directed learning.
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Citations
Citations to this article as recorded by- Do we need Moodle in medical education? A review of its impact and utility
Seri Jeong, Hyunyong Hwang
Kosin Medical Journal.2023; 38(3): 159. CrossRef - The effectiveness of Moodle's “Lesson” feature in pre-learning about arterial puncture and blood transfusion procedures
Haeyoung Lee, Sang-Shin Lee, Hyunyong Hwang
Kosin Medical Journal.2023; 38(4): 278. CrossRef - New approach to learning medical procedures using a smartphone and the Moodle platform to facilitate assessments and written feedback
Sang-Shin Lee, Haeyoung Lee, Hyunyong Hwang
Kosin Medical Journal.2022; 37(1): 75. CrossRef - How does quiz activity affect summative assessment outcomes? An analysis of three consecutive years’ data on self-directed learning
Chi Eun Oh, Hyunyong Hwang
Kosin Medical Journal.2022; 37(3): 228. CrossRef
- Do we need Moodle in medical education? A review of its impact and utility
- Considerations for experimental animal ethics in the research planning and evaluation process
- Jaewon Shim, Jeongtae Kim
- Kosin Med J. 2022;37(4):271-277. Published online December 22, 2022
- DOI: https://doi.org/10.7180/kmj.22.139
- 7,948 View
- 237 Download
- 3 Citations
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Abstract
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- Research using experimental animals has substantially contributed to advances in science and medicine. Animal experiments are nearly essential for biomedical research and development efforts. Because many animals are sacrificed, researchers should consider the welfare of experimental animals and related ethical issues, along with the successful results of their experiments. This review introduces the criteria that should be considered in terms of experimental animal ethics, based on the principles of the 3 R’s: replacement, representing careful consideration of the need for animal experiments; reduction, representing the use of the minimal number of animals to obtain meaningful experimental results; and refinement, representing continuous effects to find alternative methods to reduce pain and distress in experimental animals. Based on these principles, the following points should be considered when planning experiments: the necessity of animal experiments; alternatives to animal experiments; the relevance of the species and numbers of experimental animals; appropriate assessment and management of pain; the proper usage of sedatives, painkillers, and anesthesia; and valid timing for humane endpoints and euthanasia. These criteria are beneficial for both experimental animals and researchers because careful handling to ensure experimental animal welfare guarantees that scientific research will yield convincing, repeatable, and accurate results.
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Citations
Citations to this article as recorded by- Functional Analysis of Membrane-Associated Scaffolding Tight Junction (TJ) Proteins in Tumorigenic Characteristics of B16-F10 Mouse Melanoma Cells
Eun-Ji Ko, Do-Ye Kim, Min-Hye Kim, Hyojin An, Jeongtae Kim, Jee-Yeong Jeong, Kyoung Seob Song, Hee-Jae Cha
International Journal of Molecular Sciences.2024; 25(2): 833. CrossRef - General Principles, Designs, and Statistical Analyses in Experimental Animal Studies
Şengül Cangür
Düzce Tıp Fakültesi Dergisi.2024; 26(S1): 14. CrossRef - Applications and advancements in animal models for antiviral research on mosquito‐borne arboviruses
Megan Caifeng Tang, Ka Heng Wong, Adzzie Shazleen Azman, Rafidah Lani
Animal Models and Experimental Medicine.2024;[Epub] CrossRef
- Functional Analysis of Membrane-Associated Scaffolding Tight Junction (TJ) Proteins in Tumorigenic Characteristics of B16-F10 Mouse Melanoma Cells
- The effects of ketamine on pain control in stage IV cancer patients receiving palliative care
- Seonghoon Kim, Jihun Kang, Jongsoon Choi, Eunhee Kong
- Kosin Med J. 2022;37(1):37-45. Published online March 14, 2022
- DOI: https://doi.org/10.7180/kmj.21.003
- 3,233 View
- 84 Download
- 3 Citations
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Abstract
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- Background
We evaluated the effects of intravenous ketamine on cancer pain in stage IV cancer patients receiving palliative care.
Methods
In total, 253 stage IV cancer patients with cancer pain hospitalized at a single tertiary hospital palliative care unit were included. The ketamine group contained 112 patients receiving ketamine, and the control group comprised 141 non-ketamine users. To evaluate the odds ratios (ORs) for favorable pain control, optimal pain control, and opioid-sparing effect among ketamine users, we used multivariable logistic regression adjusted for age and objective prognosis score. Differences in the visual analog scale (VAS) score, oral morphine equivalents, inter-dose frequency, and inter-dose amount were compared between both groups at the time of ketamine introduction (T0), after 24 hours (T1), and after 48 hours (T2) using repeated-measures analysis of covariance.
Results
The ketamine group was more likely to show favorable pain control (OR, 3.84; 95% confidence interval [CI], 1.76–8.37) and an optimal response (OR, 3.99; 95% CI, 1.73–9.22) than the control group. Compared to the control group, the ketamine group showed a higher VAS score at T0, but a more evident VAS score reduction at T1 and T2 (pint<0.001). The ketamine group was less likely than the control group to experience depressive mood (OR, 0.31; 95% CI, 0.10–0.92), but had a higher risk of delirium (OR, 2.06; 95% CI, 1.12–3.91).
Conclusion
Our findings suggest that ketamine can effectively reduce refractory cancer pain in stage IV cancer patients. -
Citations
Citations to this article as recorded by- Prevalence of Pain and Factors Affecting it in Patients with Lung Cancer in Ilam
Elham Bastani, Mahsa Rizehbandi, Fariba Shokri
International Journal of Cancer Management.2024;[Epub] CrossRef - A Phase II Study About Efficacy and Safety of the Continuous IntraVenous Infusion of Ketamine as Adjuvant to Opioids in Terminally Ill Cancer Patients With Refractory Cancer Pain (CIVIK Trial)
Kwonoh Park, Jae-Joon Kim, Sang-Bo Oh, So Yeon Oh, Yun Jeong Hong, Seo-jun Kim, Eun-Ju Park, Nayeon Choi, Seon-Hi Shin, Sungeun Kim, Heejung Ko
American Journal of Hospice and Palliative Medicine®.2024;[Epub] CrossRef - Is ketamine useful for pain management in patients with stage IV cancer?
Sung Eun Kim
Kosin Medical Journal.2022; 37(1): 1. CrossRef
- Prevalence of Pain and Factors Affecting it in Patients with Lung Cancer in Ilam
- Influence of Cold Ischemia Time and Storage Period on DNA Quality and Biomarker Research in Biobanked Colorectal Cancer Tissues
- Min Gyoung Pak, Mee Sook Roh
- Kosin Med J. 2020;35(1):26-37. Published online June 30, 2020
- DOI: https://doi.org/10.7180/kmj.2020.35.1.26
- 1,839 View
- 10 Download
- 3 Citations
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Abstract
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Objectives Biobanking plays an important role in future research. Assessment and control of the preanalytical variables of biobanked tissues are fundamentals for the optimal use of biospecimens.
Methods Forty-five colorectal cancer (CRC) tissues stored at −80°C in Bio-Resource Bank were evaluated to define the influence of cold ischemia time (CIT) and storage period (SP) on DNA quality in biobanked tissues. Three CITs (less than 30 minutes (CIT-1), 30–45 minutes (CIT-2), and 45–60 minutes (CIT-3)) and three SPs (less than 1 year (SP-1), 2–3 years (SP-2), and 4–5 years (SP-3)) were chosen. NanoDrop spectrophotometer was used to determine the 260/280 ratio for DNA purity. DNA integrity was analyzed by a UV transilluminator following electrophoresis on 2% agarose gel. To evaluate the practical usability of DNA for biomarker research, KRAS mutation status was assessed by PCR amplification.
Results All DNA specimens had a 260/280 ratio ranging between 1.8 and 2.0 with the exception of one specimen (CIT-2/SP-2 group). For DNA integrity, DNA appeared as a compact, high-molecular-weight band with no or scanty low-molecular-weight smears. The concordance of KRAS mutation status between paired biobanked frozen tissues and formalin-fixed paraffin-embedded tissues was 100%. DNA remained stable in CRC tissues kept at room temperature for up to 1 hour and long-term storage up to 5 years.
Conclusions Storage conditions of our biobank are suitable for long-term (at least five years) specimen preservation with high DNA quality. These results have practical implications that could affect banking guidelines.
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Citations
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Silvia von der Heyde, Nithya Raman, Nina Gabelia, Xavier Matias-Guiu, Takayuki Yoshino, Yuichiro Tsukada, Gerry Melino, John L. Marshall, Anton Wellstein, Hartmut Juhl, Jobst Landgrebe
Cell Death & Disease.2024;[Epub] CrossRef - Advancing wide implementation of precision oncology: A liquid nitrogen‐free snap freezer preserves molecular profiles of biological samples
Hanneke van der Wijngaart, Sahil Jagga, Henk Dekker, Richard de Goeij, Sander R. Piersma, Thang V. Pham, Jaco C. Knol, Babs M. Zonderhuis, Harry J. Holland, Connie R. Jiménez, Henk M. W. Verheul, Srinivas Vanapalli, Mariette Labots
Cancer Medicine.2023; 12(9): 10979. CrossRef - Precision Medicine for Gastric Cancer: Applicability from the Perspective of Helicobacter pylori Infection
Ah Cheon Park, Sung Eun Kim
The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2023; 23(3): 231. CrossRef
- Tumor specimen cold ischemia time impacts molecular cancer drug target discovery
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