- The effects of rebamipide, sucralfate, and rifaximin against inflammation and apoptosis in radiation-induced murine intestinal injury
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Won Moon, Sangwook Lim, Yeonsoon Jung, Yuk Moon Heo, Seun Ja Park, Moo In Park, Sung Eun Kim, Jae Hyun Kim, Kyoungwon Jung
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Kosin Med J. 2022;37(4):320-341. Published online December 26, 2022
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DOI: https://doi.org/10.7180/kmj.22.140
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 Abstract
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- Background
Radiotherapy improves overall survival in patients with abdominopelvic malignancies. However, the toxic effects of radiation restrict the maximum dose that can be given, and there are no well-established preventive or therapeutic strategies. This study was conducted to evaluate whether rebamipide, sucralfate, and rifaximin have a suppressive effect on acute ionizing radiation (IR)-induced inflammation in the intestines of mice.
Methods
Thirty-six ICR mice were divided into a vehicle-treated group with sham irradiation; a vehicle-treated group with irradiation; rebamipide, sucralfate, or rifaximin-treated groups with irradiation; and a rebamipide-treated group with sham irradiation. The expression of proinflammatory, anti-inflammatory, proapoptotic, and antiapoptotic factors was investigated.
Results
The downregulated expression of nicotinamide phosphoribosyltransferase by IR was attenuated by all drugs (p<0.05). All drugs suppressed the IR-induced activation of NF-κB and phosphorylation of MAPKs (p<0.05) and attenuated the production of TNF-α, IL-1β, and IL-6 in response to IR (p<0.05). The administration of all drugs markedly attenuated IR-induced increases in iNOS, COX-2, and PGE2 (p<0.05), as well as [Ca2+] oscillations that were increased by IR. The expression of proapoptotic genes and antiapoptotic genes was suppressed and induced, respectively, by all drugs. IR treatment increased the release of cytochrome C, which was attenuated by all drugs (p<0.05). All drug treatments resulted in a significant decrease in the expression of caspase-3 and caspase-7 (p<0.05), which were both upregulated following IR treatment.
Conclusions
The administration of rebamipide, sucralfate, or rifaximin prior to radiation therapy may prevent or attenuate acute radiation-induced enterocolitis.
- How to write an original article in medicine and medical science
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Gwansuk Kang, Sung Eun Kim
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Kosin Med J. 2022;37(2):96-101. Published online June 24, 2022
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DOI: https://doi.org/10.7180/kmj.22.105
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4,687
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- Excellent research in the fields of medicine and medical science can advance the field and contribute to human health improvement. In this aspect, research is important. However, if researchers do not publish their research, their efforts cannot benefit anyone. To make a difference, researchers must disseminate their results and communicate their opinions. One way to do this is by publishing their research. Therefore, academic writing is an essential skill for researchers. However, preparing a manuscript is not an easy task, and it is difficult to write well. Following a structure may be helpful for researchers. For example, the standard structure of medical and medical science articles includes the following sections: introduction, methods, results, and discussion (IMRAD). The purpose of this review is to present an introduction for researchers, especially novices, on how to write an original article in the field of medicine and medical science. Therefore, we discuss how to prepare and write a research manuscript for publication, using the IMRAD structure. We also included specific tips for writing manuscripts in medicine and medical science.
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Citations
Citations to this article as recorded by  - Predicting Safe Liver Resection Volume for Major Hepatectomy Using Artificial Intelligence
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Kosin Medical Journal.2022; 37(4): 320. CrossRef
- Differences in Endoscopic Findings of Primary and Secondary Gastric Lymphoma
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Kyoungwon Jung, Hae Soo Jeon, Moo In Park, Il Hyeong Choe, Hyun Seung Je, Jae Hyun Kim, Sung Eun Kim, Won Moon, Seun Ja Park
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Kosin Med J. 2020;35(2):114-124. Published online December 31, 2020
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DOI: https://doi.org/10.7180/kmj.2020.35.2.114
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2,107
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Abstract
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Objectives
: Since endoscopic findings of primary gastric lymphoma are ambiguous and diverse, it is not easy to distinguish them from gastric adenocarcinoma or secondary gastric lymphoma. The aim of this study was to investigate the difference in clinical and endoscopic features between primary gastric lymphoma and gastric involvement of lymphoma.
Methods
: Forty-eight patients were enrolled in this retrospective study between June 2008 and February 2017. The patients were divided into primary gastric lymphoma group (primary group, n = 18) and gastric involvement group (secondary group, n = 30) based on whether or not they carried gastric lesions alone. Patients’ clinical characteristics, endoscopic findings and pathologic data were retrospectively reviewed based on electronic medical records.
Results
: The mean age of patients was 63.3 ± 13.1 years and 29 patients were female (60.4%). Diffuse large B-cell lymphoma pathology (81.3%), gastric body involvement (47.9%) and ulceroinfiltrative morphology on endoscopy (43.8%) were common features. Regardless of the two groups, the initial endoscopic diagnosis was considered as lymphoma only in 41.7%. Compared with the primary group, fundus (P = 0.035) and regional lymph node (P < 0.001) were significantly associated with the secondary group. However, there was no significant difference in endoscopic findings including location, size, number, and morphology of lesion.
Conclusions
: Endoscopic diagnosis of gastric lymphoma is a challenge. There is no difference in endoscopic findings between the primary and secondary groups even when confirmed separately. However, when the lesion is present in the fundus, we keep in mind the possibility of secondary gastric lymphoma.
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Citations
Citations to this article as recorded by - Endoscopic and Histopathological Characteristics of Gastrointestinal Lymphoma: A Multicentric Study
Quang Trung Tran, Thinh Nguyen Duy, Bao Song Nguyen-Tran, Tung Nguyen-Thanh, Quy Tran Ngo, Nam Phuong Tran Thi, Vi Le, Thuan Dang-Cong
Diagnostics.2023; 13(17): 2767. CrossRef - A Differential Diagnosis of Unusual Gastric Ulcer
Soo-Yoon Sung, Hyun Ho Choi, Kyung Jin Seo
Diagnostics.2022; 12(8): 1929. CrossRef
- Medical treatment of functional dyspepsia
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Sung Eun Kim
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Kosin Med J. 2015;30(1):1-11. Published online January 20, 2015
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DOI: https://doi.org/10.7180/kmj.2015.30.1.1
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Abstract
PDFPubReader ePub
- Abstract
Functional dyspepsia (FD) is a condition in which upper abdominal symptoms, such as epigastralgia, postprandial discomfort, and bloating, occur in the absence of any organic or metabolic disease that could explain the symptoms. The prevalence of FD is increasing, presumably because of an increasingly stressful environment, as well as overlap with other motility disorders such as gastroesophageal reflux diseases and irritable bowel syndrome. Numerous studies have attempted to determine the pathophysiological mechanisms of FD and establish effective FD treatment, with little success. Several therapeutic options have been explored, including Helicobacter pylori eradication, proton pump inhibitors, prokinetic agents, anti-depressant and anxiolytic agents, and acotiamide, a recent emerging drug. Through the many trials evaluating the efficacy of drugs for FD treatment, we found that it is necessary to treat according to the symptoms of FD and to use a combination of therapeutic options. Additional well-designed, prospective studies are needed to confirm the management of FD.
- Remission of Nephrotic Syndrome by the Combination of Low-dose Cyclosporine-A with Diltiazem
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Sung Eun Kim, Yeon Soon Jung, Hark Rim
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Kosin Med J. 2008;23(3):22-26. Published online September 30, 2008
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- A Case of Metastatic Small Cell Lung Carcinoma to the Thyroid Gland
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Lee La Jang, Young Sik Choi, Yo Han Park, Dae Sung Moon, Ja Kyung Kim, Sung Eun Kim, In Soo Choi, Chan Hee Yoo, Sung Jin Nam
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Kosin Med J. 2008;23(3):118-121. Published online September 30, 2008
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- A Case of Synchronous Tuberculous Lymphadenitis Appearing Like Multiple Metastatic Node in a Patient with Gastric Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma
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Sung Eun Kim, Kyu Jong Kim, Do Hyun Kim, Jun Young Song, Dae Sung Moon, Lee La Jang, Chan Hui Yoo, Won Moon, Young Ok Kim
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Kosin Med J. 2008;23(2):92-95. Published online June 30, 2008
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