- Usefulness of Kaloderm® in Finger Tip Necrosis : A Case Report
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Chung-Min Yoon, Seung Cheol Lee, Ji-An Choi
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Kosin Med J. 2021;36(2):144-147. Published online December 31, 2021
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DOI: https://doi.org/10.7180/kmj.2021.36.2.144
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 Abstract
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We experienced a case of crush injury of the hand for which we performed a flap surgery and treated the necrotic parts placement using cultured allogeneic keratinocytes (Kaloderm®) with good results.
The patient was a 31-year-old woman whose left middle finger was caught in a door, causing a crush injury. Although primary repair was performed, a 2 × 2.5-cm-sized necrosis developed, and a V-Y advancement flap was performed after the removal of dead tissues. However, a 1 × 2-cm-sized partial necrosis occurred and was treated using Kaloderm®.
After the use of Kaloderm®, the patient’s wound was healed, and no complications, except for mild pain, were observed for 1 year after the surgery.
If a necrotic site appears after flap placement of fingertip, its treatment is difficult. If used well, Kaloderm® may be a good option for necrosis of the fingertips and other areas that are difficult to cure.
- Antinociceptive Effect of BPC-157 in the Formalin-induced Pain Model
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Sang Yoong Park, So Ron Choi, Jeong Ho Kim, Seung Cheol Lee, Seong Yeop Jeong, Joon Ho Jeong, Tae Young Lee
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Kosin Med J. 2021;36(1):1-13. Published online June 30, 2021
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DOI: https://doi.org/10.7180/kmj.2021.36.1.1
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Abstract
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Objectives
Body protective compound-157 (BPC-157) is a stable gastric pentadecapeptide that has been effective in trials aiming to increase wound healing capabilities and decrease inflammatory cell influx, including studies on the healing of muscles and tendons. There are no studies about the effect of BPC-157 on pain transmission via nociception. This study examined the antinociceptive effects of BPC-157 using formalin tests and immunohistochemistry.
Methods
Rats were randomly divided into the control, morphine and BPC-157 groups. Pain behavior was quantified periodically at 5- and 35- min intervals (representative values of phases 1 and 2) by counting the number of flinches exhibited by the injected paw after injection. The dorsal root ganglia (DRG) and spinal cords (SC) were collected, and then, the number of cytokine-positive cells was determined via immunostaining.
Results
BPC-157 dose-dependently decreased the number of flinches during phase 1 but did not decrease the number of flinches during phase 2. During phase 1, interleukin-1β (IL-1β) in the DRG tissue was significantly different in the morphine, 10 μg/kg BPC-157, and 20 μg/kg BPC-157 groups. During phase 2, statistical significance was achieved in the DRG tissue in the morphine, 20 μg/kg BPC-157, and 40 μg/kg BPC-157 groups. During phase 1, interleukin-6 was significantly different in the DRG tissue in the morphine group and the SC tissue in the 10 μg/kg BPC-157 group. During phase 2, statistical significance was achieved in the morphine group and the BPC-157 20 μg/kg group in both the DRG and SC tissues. There were no significant differences in tumor necrosis factor-α between the DRG and SC tissues.
Conclusions
BPC-157 was effective during phase 1 but not during phase 2, as determined by the formalin test. BPC-157 decreased the expression of IL-1β in the DRG tissue in phases 1 and 2.
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Citations
Citations to this article as recorded by  - Stable Gastric Pentadecapeptide BPC 157 May Recover Brain–Gut Axis and Gut–Brain Axis Function
Predrag Sikiric, Slaven Gojkovic, Ivan Krezic, Ivan Maria Smoday, Luka Kalogjera, Helena Zizek, Katarina Oroz, Hrvoje Vranes, Vlasta Vukovic, May Labidi, Sanja Strbe, Lidija Baketic Oreskovic, Marko Sever, Marijan Tepes, Mario Knezevic, Ivan Barisic, Vlad
Pharmaceuticals.2023; 16(5): 676. CrossRef - The anti-nociceptive effect of BPC-157 on the incisional pain model in rats
Young-Hoon Jung, Haekyu Kim, Hyaejin Kim, Eunsoo Kim, Jiseok Baik, Hyunjong Kang
Journal of Dental Anesthesia and Pain Medicine.2022; 22(2): 97. CrossRef - Stable Gastric Pentadecapeptide BPC 157 as Useful Cytoprotective Peptide Therapy in the Heart Disturbances, Myocardial Infarction, Heart Failure, Pulmonary Hypertension, Arrhythmias, and Thrombosis Presentation
Predrag Sikiric, Mario Udovicic, Ivan Barisic, Diana Balenovic, Gordana Zivanovic Posilovic, Dean Strinic, Sandra Uzun, Suncana Sikiric, Ivan Krezic, Helena Zizek, Haidi Yago, Slaven Gojkovic, Ivan Maria Smoday, Luka Kalogjera, Hrvoje Vranes, Marija Sola,
Biomedicines.2022; 10(11): 2696. CrossRef - Stable Gastric Pentadecapeptide BPC 157 and Striated, Smooth, and Heart Muscle
Mario Staresinic, Mladen Japjec, Hrvoje Vranes, Andreja Prtoric, Helena Zizek, Ivan Krezic, Slaven Gojkovic, Ivan Maria Smoday, Katarina Oroz, Eva Staresinic, Vilim Dretar, Haidi Yago, Marija Milavic, Suncana Sikiric, Eva Lovric, Lovorka Batelja Vuletic,
Biomedicines.2022; 10(12): 3221. CrossRef
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