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Seon Young Seo 1 Article
Therapeutic Effects of Prolonged Release Melatonin (Circadin®) in Patients with Overactive Bladder and Chronic Insomnia in More Than 55 Years Old
Min Jung Park, Seon Young Seo, Hyun Jun Park, Jih Hoon Park, Mi Young Lim, Nam Cheol Park
Kosin Med J. 2020;35(2):101-113.   Published online December 31, 2020
DOI: https://doi.org/10.7180/kmj.2020.35.2.101
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Abstract PDFPubReader   ePub   
Objectives

Bladder storage symptoms including nocturia is the most common cause of sleep disturbance in all age groups. Sleep disturbance is also a main cause of nocturia so that sleep recovery can clinically improve nocturia. Melatonin has main action to induce sleep and additional effects of smooth muscle relaxation, free radical scavenging, anti-inflammation, et cetera. This study was evaluated the improvement of sleep quality after administrating prolonged-release melatonin in elderly patients with overactive bladder and chronic insomnia.

Methods

This clinical trial was performed with a randomized single open study. Thirty-seven patients with overactive bladder and chronic insomnia were initially enrolled in this study. After 4 or 12 weeks treating with 2 mg of prolonged-release melatonin, clinical outcomes were evaluated with OABSS, IPSS, PSQI and WHO 5 well-being index.

Results

Of the 37 patients, 34 (91.9%) were included in the ITT group and 26 (76.5%) in the PP group. In the primary outcome of PP group, significant improvements were observed in total OABSS and nocturia frequencies at 12 weeks, respectively. Secondary outcome measurement including in voiding, storage symptoms, and total IPSS scores showed the improvement at 4 and 12 weeks and in total and sleep quality PSQI scores at 12 weeks, and in quality of life scores of the WHO 5 well-being index at 12 weeks. Only one (3.8%) adverse event was observed.

Conclusions

These results suggest clearly that prolonged-release melatonin in elderly patients with overactive bladder and chronic insomnia has the potential to control concomitant voiding and sleep difficulty.

Citations

Citations to this article as recorded by  
  • Melatonin and melatonin receptor agonists in the treatment of nocturia: A systematic review
    Christine Anh Burke, Victor W. Nitti, Lynn Stothers
    Neurourology and Urodynamics.2024; 43(4): 826.     CrossRef

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