- Post-percutaneous core needle biopsy sputum cytology: diagnostic value and factors for positive prediction in diagnosing malignancy
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Sang Kyu Lee, Hee Kang, Min Jung Jung, Sekyoung Park, Ki Nam Lee
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Kosin Med J. 2023;38(3):201-209. Published online August 16, 2023
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DOI: https://doi.org/10.7180/kmj.23.127
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 Abstract
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- Background
This study evaluated the diagnostic yield and positive predictive factors of post-percutaneous core needle biopsy (PCNB) sputum cytology in diagnosing malignancy.
Methods
This retrospective study included patients who underwent PCNB at a single center from January 2014 to March 2022. Patient demographics, lung lesion characteristics on computed tomography, underlying lung disease, post-PCNB complications, histopathologic results of PCNB, post-PCNB sputum specimens, and final diagnoses were reviewed. The diagnostic yields and related factors were analyzed.
Results
Overall, 177 consecutive patients with sputum specimens obtained after PCNB for intrapulmonary lesions were enrolled. Among them, 152 patients had a final diagnosis of malignancy. Diagnostic sputum specimens with atypical or malignant cells were obtained in 12 patients. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of sputum cytology were 7.89%, 100%, 20.90%, 100%, and 15.15%, respectively. Lesion size, air-bronchogram, lesion multiplicity, and the cell type of squamous cell and adenocarcinoma differed significantly between the groups with diagnostic versus non-diagnostic sputum (p<0.05). The lesion size (odds ratio [OR], 1.035; 95% confidence interval [CI], 1.008–1.064; p=0.013), presence of air-bronchogram (OR, 23.485; 95% CI, 2.532–217.316; p=0.005), and squamous cell carcinoma (OR, 7.397; 95% CI, 1.773–30.865; p=0.006) were significantly associated with a diagnostic sputum specimen post-PCNB.
Conclusions
Although post-PCNB sputum cytology had low sensitivity in diagnosing lung cancer, it showed diagnostic results in some peripheral lung cancer patients who have squamous cell types, relatively large tumors, and air-bronchograms in the lesions.
- Mucinous precursor lesions of mucinous carcinoma in breast: Incidence and histopathologic features
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Min Jung Jung, Young Ok Kim
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Kosin Med J. 2015;30(2):131-139. Published online January 20, 2015
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DOI: https://doi.org/10.7180/kmj.2015.30.2.131
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Abstract
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- Abstract
Objectives
Columnar cell lesion (CCL), atypical ductal hyperplasia (ADH) and ductal carcinoma in situ (DCIS) may be premalignant lesion of mammary invasive carcinoma. A few recent investigators reported that the precursor lesions exhibited mucin production and they might be potential precursor lesion for mucinous carcinoma (mCA). This study aims to investigate the incidence and histopathologic characteristics of mucinous precursor lesions, including mucinous DCIS (mDCIS) and mucinous CCL (mCCL).
Methods
We retrospectively analyzed invasive carcinomas with mucin. Cases were grouped into three subgroups: pure mCA, mixed mCA, and invasive carcinoma of no special type with mucin production (IC of NST-m). Precursor lesions were evaluated with PAS and alcian blue staining.
Results
Total 27 cases of invasive carcinoma with mucin were analysed and classified as 18 pure mCA, 7 mixed mCA, and 2 IC of NST-m. mDCISs were found in 12 pure mCA, 4 mixed mCA and 2 IC of NST-m. mCCLs were found in 7 pure mCA and 2 mixed mCA. Majority of mucin was identified in both cytoplasm and ductal lumen, while some tumors exhibited only cytoplasmic mucin. We also observed three patterns of mDCIS classifiable by location of mucin and architecture of tumor cells.
Conclusions
Cytoplasmic mucin suggested that mucinous feature of precursor lesions in the vicinity of mCA might not be a passive morphologic finding but be involved in development of mCA.
- The Gene Profiling of Colon Cancer-Associated Genes From Colon Cancer Tissue
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Min Jung Jung, Hee Kyung Chang
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Kosin Med J. 2008;23(4):12-19. Published online December 31, 2008
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- Bronchogenic Cyst - Experience of One Hospital for Ten Years
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Min Jung Jung
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Kosin Med J. 2008;23(3):27-31. Published online September 30, 2008
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- Microsatellite Instability and Pathologic Characteristics of Sporadic Intestinal Type Adenocarcinoma of Stomach
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Chang Hee Cho, Yu Chan Hong, Ji Hyun Ahn, Kyung Hyun Choi, Sang Ho Lee, Young Myeong Shin, Ki Young Yoon, Min Jung Jung, Hee Kyung Chang
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Kosin Med J. 2007;22(2):18-23. Published online December 31, 2007
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- The Incidence and Pathologic Analysis for Patients with Large Gastric Tumors over 8cm
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So Yoon Choi, Young Jin Lee, Ji Hyun Ahn, Min Jung Jung, Hee Kyung Chang
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Kosin Med J. 2007;22(1):43-48. Published online June 30, 2007
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- Detection of Mycobacterium in the Patients with Inflammatory Bowel Disease
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Seo Ryong Han, Min Jung Jung, Hee Kyung Chang
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Kosin Med J. 2006;21(2):15-19.
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