Kosin Medical Journal

Kwang Hyuk Kim

17 Articles

Effects of L-ascorbic acid on the production of pro-inflammatory and anti-inflammatory cytokines in C57BL/6 mouse splenocytes: Eun Hee Kong, Sun Young Ma, Jee Yeong Jeong, Kwang Hyuk Kim; Kosin Med J. 2015;30(1):41-49. Published online January 20, 2015; DOI: https://doi.org/10.7180/kmj.2015.30.1.41

3,032 View
34 Download
22 Citations

Abstract Objective

The imbalance between pro-inflammatory and anti-inflammatory cytokines may underlie different pain states. Although ascorbic acid is the most important physiological antioxidant that affects host defense mechanisms and immune homeostasis, there is limited information on the effects of ascorbic acid on the production of cytokines.

Methods

In this study, we investigated the in vitro effect of L-ascorbic acid (AA) on the production of pro-inflammatory and anti-inflammatory cytokines by stimulating C57BL/6 mouse splenocytes with the polyclonal activators lipopolysaccharide or concanavalin A.

Results

AA significantly downregulated the expression of IL-6, IL-12, and TNF-α at 48 h and 72 h in mouse splenocytes treated with a combination of polyclonal activators and AA. AA treatment also resulted in upregulation of IL-4 and IL-10 at 72 h. These findings demonstrated that AA significantly potentiated production of anti-inflammatory cytokines whereas there was an inverse association between AA and expression of pro-inflammatory cytokines in mouse splenocytes.

Conclusion

AA may have potential applications in the reduction of inflammatory pain because of its function in modulating the production of cytokines. However, further in vivo investigations are necessary to elucidate the mechanisms involved.

Citations

Citations to this article as recorded by

In-vitro administration of vitamin C solution induces multiple cellular mechanisms in common carp brain cells and carp-derived leukocytes, resisting infection by Koi herpesvirus
Ehdaa Eltayeb Eltigani Abdelsalam, Zuzana Bláhová, Veronika Piačková
Aquaculture.2025; 595: 741572. CrossRef
Functional and molecular insights in topical wound healing by ascorbic acid
Bhawana Jha, Ankit Majie, Kankan Roy, Bapi Gorain
Naunyn-Schmiedeberg's Archives of Pharmacology.2025;[Epub] CrossRef
Interleukin-8 and neutrophil extracellular traps in children with lupus nephritis and vitamin C deficiency
Chanunya Santiworakul, Wilasinee Saisorn, Nuanpan Siripen, Asada Leelahavanichkul, Pornpimol Rianthavorn
Pediatric Nephrology.2024; 39(4): 1135. CrossRef
Fisetin ameliorates polycystic ovary syndrome in rats via a mechanistic modulation of AMP-activated protein kinase and SIRT1 molecular pathway
Simerjeet Kaur Chahal, Atul Kabra
Naunyn-Schmiedeberg's Archives of Pharmacology.2024; 397(12): 10017. CrossRef
Insights into bioactive constituents of onion (Allium cepa L.) waste: a comparative metabolomics study enhanced by chemometric tools
Mariam M. Elattar, Hala M. Hammoda, Doaa A. Ghareeb, Shaymaa A. Abdulmalek, Fatma. A. Abdelrahim, Inas A. K. Seif, Hend M. Dawood, Reham S. Darwish
BMC Complementary Medicine and Therapies.2024;[Epub] CrossRef
The effect of vitamin C on the recovery of activity and survival of autografted ovaries through inhibition of oxidation and inflammation
Maedeh Talesh Sasani, Monireh Mahmoodi, Malek Soleimani Mehranjani
Tissue and Cell.2024; 91: 102564. CrossRef
LPS-induced systemic inflammation is suppressed by the PDZ motif peptide of ZO-1 via regulation of macrophage M1/M2 polarization
Hyun-Chae Lee, Sun-Hee Park, Hye Min Jeong, Goeun Shin, Sung In Lim, Jeongtae Kim, Jaewon Shim, Yeong-Min Park, Kyoung Seob Song
eLife.2024;[Epub] CrossRef
Antioxidant Activity, Stability in Aqueous Medium and Molecular Docking/Dynamics Study of 6-Amino- and N-Methyl-6-amino-L-ascorbic Acid
Lara Saftić Martinović, Nada Birkic, Vedran Miletić, Roberto Antolović, Danijela Štanfel, Karlo Wittine
International Journal of Molecular Sciences.2023; 24(2): 1410. CrossRef
Anticancer Activity of Mineral-Supplemented Organically Cultivated Carrot on HT-29 Cells and Its Anti-Inflammatory Effect on Mice Splenocytes
Yanni Pan, Yeon-Jun Lee, Sin-Il Sin, Seung-Hwan Park, Kun-Young Park
Applied Sciences.2023; 13(16): 9209. CrossRef
Sitagliptin Attenuates the Cognitive Deficits in L‐Methionine‐Induced Vascular Dementia in Rats
Suzan A. Khodir, Manar A. Faried, Huda I. Abd-Elhafiz, Eman M. Sweed, Krzysztof Siemianowicz
BioMed Research International.2022;[Epub] CrossRef
Combination Treatment of Omega‐3 Fatty Acids and Vitamin C Exhibited Promising Therapeutic Effect against Oxidative Impairment of the Liver in Methotrexate‐Intoxicated Mice
Mohammed Alorabi, Doha Saad Mohammed, Gomaa Mostafa-Hedeab, Suzy A. El-Sherbeni, Walaa A. Negm, Ali Ismail A. Mohammed, Hayder M. Al-kuraishy, Nani Nasreldin, Saqer S. Alotaibi, Bashir Lawal, Gaber El-Saber Batiha, Carlos Adam Conte-Junior, Valeria Pasciu
BioMed Research International.2022;[Epub] CrossRef
STAT3 inhibition decreases ATP-induced MUC8 gene expression in human airway epithelial cells
Cheol Hong Kim, Kyoung Seob Song
Kosin Medical Journal.2022; 37(2): 134. CrossRef
Critical review on the immunomodulatory activities of carrot’s β-carotene and other bioactive compounds
Gemala Anjani, Fitriyono Ayustaningwarno, Rafika Eviana
Journal of Functional Foods.2022; 99: 105303. CrossRef
Antioxidative and Anti-Inflammatory Activity of Ascorbic Acid
Agnieszka Gęgotek, Elżbieta Skrzydlewska
Antioxidants.2022; 11(10): 1993. CrossRef
The Effect of Ascorbic Acid on Interleukin-10 and Tumor Necrosis Factor-α Cytokines in Rattus norvegicus with Endometritis
Muhammad Oky Prabudi, M. F. G. Siregar, I. P. A. Nasution, S. Ilyas
Open Access Macedonian Journal of Medical Sciences.2021; 9(A): 798. CrossRef
Effect of Ascorbic Acid on Differentiation, Secretome and Stemness of Stem Cells from Human Exfoliated Deciduous Tooth (SHEDs)
Shilpa Bhandi, Ahmed Alkahtani, Mohammed Mashyakhy, Abdulaziz S. Abumelha, Nassreen Hassan Mohammad Albar, Apathsakayan Renugalakshmi, Mazen F. Alkahtany, Ali Robaian, Asma Saleh Almeslet, Vikrant R. Patil, Saranya Varadarajan, Thodur Madapusi Balaji, Rod
Journal of Personalized Medicine.2021; 11(7): 589. CrossRef
Development of a novel in vitro insulin resistance model in primary human tenocytes for diabetic tendinopathy research
Hui Yee Tan, Sik Loo Tan, Seow Hui Teo, Margaret M. Roebuck, Simon P. Frostick, Tunku Kamarul
PeerJ.2020; 8: e8740. CrossRef
Active Cousinia thomsonii Extracts Modulate Expression of Crucial Proinflammatory Mediators/Cytokines and NFκB Cascade in Lipopolysaccharide-Induced Albino Wistar Rat Model

Khalid Bashir Dar, Ishfaq Shafi Khan, Shajrul Amin, Aijaz Hassan Ganie, Aashiq Hussain Bhat, Showkat Ahmad Dar, Bilal Ahmad Reshi, Showkat Ahmad Ganie
Journal of Inflammation Research.2020; Volume 13: 829. CrossRef
The potential cytoprotective effect of Vitamin C and Vitamin E on monosodium glutamate-induced testicular toxicity in rats
Safaa Mohamed El Kotb, Dalia El-sayed El-ghazouly, Omnia Ameen
Alexandria Journal of Medicine.2020; 56(1): 134. CrossRef
Combination of ascorbic acid and calcitriol attenuates chronic asthma disease by reductions in oxidative stress and inflammation
Farzaneh Kianian, Seyed Morteza Karimian, Mehri Kadkhodaee, Nasrin Takzaree, Behjat Seifi, Soheila Adeli, Elham Harati, Hamid Reza Sadeghipour
Respiratory Physiology & Neurobiology.2019; 270: 103265. CrossRef
Evaluation of Ascorbic Acid or Curcumin Formulated in a Solid Dispersion on Salmonella Enteritidis Infection and Intestinal Integrity in Broiler Chickens
Daniel Hernandez-Patlan, Bruno Solis-Cruz, Karine P. Pontin, Juan D. Latorre, Xochitl Hernandez-Velasco, Ruben Merino-Guzman, Abraham Mendez-Albores, Billy M. Hargis, Raquel Lopez-Arellano, Guillermo Tellez-Isaias
Pathogens.2019; 8(4): 229. CrossRef
Amelioration ofEscherichia coli‐induced endometritis with ascorbic acid in non‐pregnant mouse models
Enitome Evi Bafor, Ikechukwu Onwukpa, Anne Oghenekevwe Itemire, Osemelomen Omoruyi, Ejiroghene Eferoba‐Idio, Kevin Odega, Osas Jim Eghianruwa
American Journal of Reproductive Immunology.2018;[Epub] CrossRef

Effects of Capsaicin on the Production of Proinflammatory Cytokines in Mice: Kwang Hyuk Kim; Kosin Med J. 2008;23(4):58-63. Published online December 31, 2008

528 View
0 Download

PDF

Inhibitory Effects of Berberine on Proliferation of Human Leukemia Cells: Eun Young Kim, Kwang Hyuk Kim; Kosin Med J. 2007;22(2):14-17. Published online December 31, 2007

416 View
0 Download

PDF

Effects of Lidocaine and Propofol on Lymphocyte Proliferation in Mice: Su Ryoung Chung, Jong Seong Kim, Kwang Hyuk Kim; Kosin Med J. 2007;22(1):9-14. Published online June 30, 2007

457 View
0 Download

PDF

Effects of Eucalyptus and Geranium on Tumor Cell Growth: Kwang Hyuk Kim; Kosin Med J. 2006;21(1):318-322.

302 View
0 Download

PDF

Growth Patterns of Methicillin Resistant Staphylococcus aureus in β-Lactam Antibiotic Containing Muller-Hinton Broth: Myung Hoon Joh, Kwang Hyuk Kim, Myung Woong Chang; The Journal of Kosin Medical College. 1992;8(2):105-134.

418 View
1 Download

PDF

The Influence of Linoleic acid and Ursolic Acid on Mouse Natural Killer Cell Activity: Kwang Hyuk Kim, Myung Woong Chang, Yangil Sunwoo; The Journal of Kosin Medical College. 1992;8(1):35-46.

539 View
1 Download

PDF

Antimicrobial susceptibility of Ureaplasma urealyticum: Myung Woong Chang, Kwang Hyuk Kim, In Dal Park, Gyung Sig Yoo, Seung Kyun Lim; The Journal of Kosin Medical College. 1991;7(1):25-38.

411 View
0 Download

PDF

Karyological Characteristics of K-56 Cells Infected with Ureaplasma urealyticum: Kwang Hyuk Kim, Gyung Sig Yoo, In Dal Park, Myung Woong Chang; The Journal of Kosin Medical College. 1990;6(2):135-146.

506 View
0 Download

PDF

Ureaplasma Infection of Human Chronic Myelogenous Leukemia Cell Line(K-562): Kwang Hyuk Kim, Gyung Sig Yoo, In Dal Park, Myung Woong Chang; The Journal of Kosin Medical College. 1989;5(2):13-19.

414 View
5 Download

PDF

Chromosome Aberration of Human Lymphocyte Infected with Ureaplasma urealyticum: Myung Woong Chang, Kwang Hyuk Kim, In Dal Park, Gyung Sig Yoo; The Journal of Kosin Medical College. 1989;5(2):1-11.

456 View
3 Download

PDF

Electrom Microscopic studies on the Rise and Fall of Attached Ureaplasma urealyticum to Human Leukemia Cells: Myung Woong Chang, Kwang Hyuk Kim, In Dal Park; The Journal of Kosin Medical College. 1988;4(1):71-78.

481 View
0 Download

PDF

Isolation rates of Chlamydia trachomatis and Ureaplasma urealyticum from out-patients of obstetrics and Gynecology: Myung Woong Chang, Kwang Hyuk Kim, In Dal Park, Kee Muk Chung, Jae Hoon Chung; The Journal of Kosin Medical College. 1987;3(1):49-58.

540 View
1 Download

PDF

ANTIBIOTIC SUSCEPTIBILITY TEST AGAINST U. UREALYTICUM ISOLATED FROM CLINICAL SPECIMEN.: Myung Woong Chang, Kwang Hyuk Kim, In Dal Park, Kwang Sung Bae; The Journal of Kosin Medical College. 1987;3(1):43-48.

495 View
0 Download

PDF

Interferon Production in Human Lymphocyte Infected with Ureaplasma Urealyticum: Kwang Hyuk Kim, In Dal Park, Myung Woong Chang; The Journal of Kosin Medical College. 1986;2(1):31-36.

369 View
0 Download

PDF

Adherence of Ureaplasma Urealyticum to the Surface of Vero Cells: Myung Woong Chang, Kwang Hyuk Kim, In Dal Park; The Journal of Kosin Medical College. 1986;2(1):37-43.

450 View
0 Download

PDF

Effects of the Plant Growth Hormones on the Growth of Mycobacterium tuberculosis: yung-Woong Chang, Kwang Hyuk Kim, In Dal Park; The Journal of Kosin Medical College. 1985;1(1):19-24.

494 View
0 Download

PDF

Author index