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Ho Sik Shin 10 Articles
Impact of dietary education on blood cadmium and mercury levels in chronic kidney disease: a path to renal health improvement
Ho Sik Shin
Kosin Med J. 2023;38(2):73-74.   Published online June 26, 2023
DOI: https://doi.org/10.7180/kmj.23.130
  • 1,700 View
  • 18 Download
PDFPubReader   ePub   
Comparison of circuit patency and exchange rates between the original and generic versions of nafamostat mesylate in critically ill adults receiving continuous renal replacement therapy
Sujung Heo, Yanghyeon Kim, Nagyeom Lee, Ye Na Kim, Ho Sik Shin, Yeonsoon Jung, Hark Rim
Kosin Med J. 2023;38(1):36-42.   Published online March 20, 2023
DOI: https://doi.org/10.7180/kmj.22.137
  • 1,854 View
  • 40 Download
Abstract PDFPubReader   ePub   
Background
Nafamostat mesylate is widely used as an anticoagulant in continuous renal replacement therapy (CRRT). The generic versions of nafamostat mesylate have identical main components to the original product. However, it is questionable whether the generic versions have the same efficacy as the original. Therefore, we compared the circuit patency and exchange rates of the original nafamostat mesylate and a generic version to determine which is more efficient as an anticoagulant in CRRT.
Methods
This retrospective study enrolled 1,255 patients hospitalized to receive CRRT who received the original version of nafamostat mesylate or a generic version between January 2010 and July 2018. We evaluated the filter lifespan, number of filters used per day, mean blood flow, and transmembrane pressure (TMP).
Results
The mean filter lifespan was 36.3±15.1 hours in the original product group and 22.2±16.2 hours in the generic product group, which was not a statistically significant difference (p=0.060). The mean TMP was 62.2±47.3 mmHg in the original product group and 74.5±45.6 mmHg in the generic product group (p=0.045).
Conclusions
This retrospective study suggests no meaningful difference in filter lifespan between the original and generic versions of nafamostat mesylate. However, TMP was lower in the original product group than in the generic product group.
The Natural Course of Total Kidney Volume in Patients with Autosomal Dominant Polycystic Kidney Disease undergoing Hemodialysis
Ye Na Kim, Yeonsoon Jung, Ho Sik Shin, Hark Rim, Jung Gu Park, Dong Yeol Lee, Joong Kyung Kim
Kosin Med J. 2021;36(2):109-115.   Published online December 31, 2021
DOI: https://doi.org/10.7180/kmj.2021.36.2.109
  • 1,746 View
  • 15 Download
Abstract PDFPubReader   ePub   
Objectives

The natural course of native kidneys after hemodialysis initiation in patients with autosomal dominant polycystic kidney disease (ADPKD) remains poorly understood.

Methods

We measured the total volumes of native kidneys in 12 patients who had at least one enhanced computed tomography (CT) image both before and after initiation of hemodialysis (group 1) and in 18 patients who had no image before dialysis but more than two images after dialysis (group 2). In patients with images, the last image was used for analysis only after dialysis.

Results

The mean total kidney volume (TKV) (± SD) before hemodialysis initiation was 3132 ± 1413 mL and the mean TKV of the last image was 3047 ± 1323 mL in group 1. The mean TKV change rate (%) was −5.2 ± 27.4% (P > 0.05) during follow-up of 3.9 ± 1.9 years in group 1. The mean TKV change rate was 2.8 ± 34.4% (P > 0.05) in group 2. The follow-up period after dialysis initiation ranged from 4.2 ± 4.7 to 8.0 ± 5.2 years.

Conclusions

The results suggest that the TKV of native polycystic kidneys decreases substantially after hemodialysis initiation. This reduction occurs mainly during the early post-hemodialysis period and followed by a slow enlargement of TKV.

Relationships of Total Lymphocyte Count and Subpopulation Lymphocyte Counts with the Nutritional Status in Patients Undergoing Hemodialysis/Peritoneal Dialysis
Ye Na Kim, Ho Sik Shin
Kosin Med J. 2017;32(1):58-71.   Published online January 19, 2017
DOI: https://doi.org/10.7180/kmj.2017.32.1.58
  • 1,608 View
  • 5 Download
  • 1 Citations
Abstract PDFPubReader   ePub   
Objectives

Dialysis patients’ nutritional indicators are quite subjective and complex and cannot be easily measured in clinical settings. Based on previous reports that total lymphocyte count (TLC) and subpopulation lymphocyte counts (SLCs) are associated with nutritional status in patients with dialysis, we designed this study to examine the relationships of the TLC and SLCs with clinical outcome and nutritional status in patients undergoing maintenance hemodialysis (HD) and peritoneal dialysis (PD).

Methods

In this prospective, observational study, we enrolled 66 patients (50 HD patients and 16 PD patients) receiving stable maintenance dialysis. We evaluated the baseline parameters of height; weight; TLC; SLCs expressing CD3, CD4, CD8 and CD19; CBC; iron profile (iron, TIBC, ferritin); BUN; Cr; Na; K; total CO2; Ca; P; iPTH; protein; albumin; total cholesterol; HDL; LDL; uric acid and CRP and calculated Onodera’s prognostic nutritional index (OPNI) and the Geriatric Nutritional Risk Index (GNRI) at baseline and three months. To analyze differences in the TLC and SLCs between the HD group and the PD group, we performed an independent samples t-test. Logistic regression analysis was performed to predict malnutrition in dialysis patients. In addition, to analyze changes in TLC, SLCs expressing each marker (CD3, CD4, CD8 and CD19) and other nutritional markers, we performed general linear model (GLM)-repeated measures ANOVA.

Results

Mean age was 55.8 ± 12.7 years in HD paitents and 49.8 ± 14.5 years in PD patients. The duration of dialysis was 59.7 ± 52.9 months in HD patients and 66.1 ± 33.6 years in PD patients. Logistic regression analysis revealed that patients aged 60 years or older, women, and those whose CD19 SLCs were lower than 100 had a higher risk of developing malnutrition. In GLM-repeated measures ANOVA, CD19 SLCs were significantly higher in women and in patients with a shorter period of dialysis.

Conclusions

Our results indicate that GNRI, OPNI, TLC and SLCs (especially CD19 count) may be significant nutritional markers in HD and PD patients.

Citations

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  • Inter-correlations Among Clinical, Metabolic, and Biochemical Parameters and Their Predictive Value in Healthy and Overtrained Male Athletes: The EROS-CORRELATIONS Study
    Flavio A. Cadegiani, Claudio E. Kater
    Frontiers in Endocrinology.2019;[Epub]     CrossRef
A Case of Hydrothorax Aggravated by Peritoneal Dialysate Leakage in Compensated Liver Cirrhosis Patient with Ascites
Gain You, Ho Sik Shin, Yeon Soon Jung, Hark Rim
Kosin Med J. 2014;29(1):53-57.   Published online December 17, 2014
DOI: https://doi.org/10.7180/kmj.2014.29.1.53
  • 1,370 View
  • 4 Download
Abstract PDFPubReader   
Abstract

The cirrhotic patients with ascites present unique challenge to the renal caregiver. Hydrothorax in a cirrhotic patient treated with PD poses a diagnostic dilemma. Proposed mechanisms for the development of a pleuroperitoneal communication include congenital diaphragmatic defects, acquired weakening of diaphragmatic fibers caused by high intra-abdominal pressures during peritoneal dialysis, and impairments in lymphatic drainage. Pleural fluid analysis and diagnostic imaging assist in differentiation from other causes of pleural effusion. We report a case of hydrothorax in a compensated cirrhotic patient after recent introduction to peritoneal dialysis.

Bladder Pheochromocytoma Presented as Thunderclap Headache Triggered by Urination and Angina Pectoris
You Jin Han, Ho Sik Shin, Yeon Soon, Jung Hark Rim, So Young Ock, Eun Jeong Kim
Kosin Med J. 2013;28(2):161-165.   Published online January 19, 2013
DOI: https://doi.org/10.7180/kmj.2013.28.2.161
  • 1,845 View
  • 2 Download
  • 1 Citations
Abstract PDFPubReader   ePub   

Pheochromocytoma is a catecholamine-producing tumor characterized by hypertension, headache, tachycardia, excessive diaphoresis, and angina pectoris. The thunderclap headache is so named because the pain strikes suddenly and severely. Although the symptoms of bladder pheochromocytoma are rather evident, the diagnosis of this rare neuroendocrine tumor can be missed. This study reports the case of a woman diagnosed with bladder pheochromocytoma who experienced thunderclap headache triggered by urination and angina pectoris as an initial manifestation. This case study suggests that thunderclap headache and angina pectoris occurring concurrently with sudden blood pressure elevation during or immediately after urination are important diagnostic clues of bladder pheochromocytoma.

Citations

Citations to this article as recorded by  
  • Micturition induced primary thunderclap headache in an 11-year-old with response to nimodipine
    Katherine M. Wojcicki, Rachel L. Evans, Benjamin Zwain, Stephen Deputy
    Journal of the Neurological Sciences.2021; 426: 117474.     CrossRef
A Case of Invasive Aspergillosis of the Paranasal Sinuses Treated with Surgery and Voriconazole after Kidney Transplantation
Ho Sik Shin, Sin Jun Lee, Yeon Soon Jung, Hark Rim
Kosin Med J. 2011;26(2):183-189.   Published online December 1, 2011
  • 388 View
  • 1 Download
PDF
Glomerular Filtration Rate by Cystatin C-Based Prediction Equations Compared with Serum Creatinine Based GFR in Healthy Young Korean Men
Ho Sik Shin, Yeon Soon Jung, Hark Rim
Kosin Med J. 2009;24(2):20-26.   Published online December 31, 2009
  • 326 View
  • 2 Download
PDF
Unusual Presentation of Acute Abdomen in Hemorrhagic Fever with Renal Syndrome: A Report of One Case
Ho Sik Shin, Yeon Soon Jung, Hark Rim
Kosin Med J. 2009;24(2):199-202.   Published online December 31, 2009
  • 272 View
  • 0 Download
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The interdialytic weight gain as a nutritional parameter in hemodialysis patients
Ho Sik Shin, Yeon Soon Jung, Hark Rim
Kosin Med J. 2006;21(1):126-133.
  • 302 View
  • 1 Download
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