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Hark Rim 22 Articles
Comparison of circuit patency and exchange rates between the original and generic versions of nafamostat mesylate in critically ill adults receiving continuous renal replacement therapy
Sujung Heo, Yanghyeon Kim, Nagyeom Lee, Ye Na Kim, Ho Sik Shin, Yeonsoon Jung, Hark Rim
Kosin Med J. 2023;38(1):36-42.   Published online March 20, 2023
DOI: https://doi.org/10.7180/kmj.22.137
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Abstract PDFPubReader   ePub   
Background
Nafamostat mesylate is widely used as an anticoagulant in continuous renal replacement therapy (CRRT). The generic versions of nafamostat mesylate have identical main components to the original product. However, it is questionable whether the generic versions have the same efficacy as the original. Therefore, we compared the circuit patency and exchange rates of the original nafamostat mesylate and a generic version to determine which is more efficient as an anticoagulant in CRRT.
Methods
This retrospective study enrolled 1,255 patients hospitalized to receive CRRT who received the original version of nafamostat mesylate or a generic version between January 2010 and July 2018. We evaluated the filter lifespan, number of filters used per day, mean blood flow, and transmembrane pressure (TMP).
Results
The mean filter lifespan was 36.3±15.1 hours in the original product group and 22.2±16.2 hours in the generic product group, which was not a statistically significant difference (p=0.060). The mean TMP was 62.2±47.3 mmHg in the original product group and 74.5±45.6 mmHg in the generic product group (p=0.045).
Conclusions
This retrospective study suggests no meaningful difference in filter lifespan between the original and generic versions of nafamostat mesylate. However, TMP was lower in the original product group than in the generic product group.
The Natural Course of Total Kidney Volume in Patients with Autosomal Dominant Polycystic Kidney Disease undergoing Hemodialysis
Ye Na Kim, Yeonsoon Jung, Ho Sik Shin, Hark Rim, Jung Gu Park, Dong Yeol Lee, Joong Kyung Kim
Kosin Med J. 2021;36(2):109-115.   Published online December 31, 2021
DOI: https://doi.org/10.7180/kmj.2021.36.2.109
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Abstract PDFPubReader   ePub   
Objectives

The natural course of native kidneys after hemodialysis initiation in patients with autosomal dominant polycystic kidney disease (ADPKD) remains poorly understood.

Methods

We measured the total volumes of native kidneys in 12 patients who had at least one enhanced computed tomography (CT) image both before and after initiation of hemodialysis (group 1) and in 18 patients who had no image before dialysis but more than two images after dialysis (group 2). In patients with images, the last image was used for analysis only after dialysis.

Results

The mean total kidney volume (TKV) (± SD) before hemodialysis initiation was 3132 ± 1413 mL and the mean TKV of the last image was 3047 ± 1323 mL in group 1. The mean TKV change rate (%) was −5.2 ± 27.4% (P > 0.05) during follow-up of 3.9 ± 1.9 years in group 1. The mean TKV change rate was 2.8 ± 34.4% (P > 0.05) in group 2. The follow-up period after dialysis initiation ranged from 4.2 ± 4.7 to 8.0 ± 5.2 years.

Conclusions

The results suggest that the TKV of native polycystic kidneys decreases substantially after hemodialysis initiation. This reduction occurs mainly during the early post-hemodialysis period and followed by a slow enlargement of TKV.

A Case of Hydrothorax Aggravated by Peritoneal Dialysate Leakage in Compensated Liver Cirrhosis Patient with Ascites
Gain You, Ho Sik Shin, Yeon Soon Jung, Hark Rim
Kosin Med J. 2014;29(1):53-57.   Published online December 17, 2014
DOI: https://doi.org/10.7180/kmj.2014.29.1.53
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Abstract PDFPubReader   
Abstract

The cirrhotic patients with ascites present unique challenge to the renal caregiver. Hydrothorax in a cirrhotic patient treated with PD poses a diagnostic dilemma. Proposed mechanisms for the development of a pleuroperitoneal communication include congenital diaphragmatic defects, acquired weakening of diaphragmatic fibers caused by high intra-abdominal pressures during peritoneal dialysis, and impairments in lymphatic drainage. Pleural fluid analysis and diagnostic imaging assist in differentiation from other causes of pleural effusion. We report a case of hydrothorax in a compensated cirrhotic patient after recent introduction to peritoneal dialysis.

A Case of Adult onset Bartter Syndrome with Nephrocalcinosis
Min Gyu Park, Tae Won Lim, Hee Taek Oh, Seung Un Song, Dong Heo, Hark Rim
Kosin Med J. 2014;29(1):75-79.   Published online December 17, 2014
DOI: https://doi.org/10.7180/kmj.2014.29.1.75
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Abstract PDFPubReader   
Abstract

Bartter syndrome is a renal tubular defect in electrolyte transport characterized by hypokalemia, metabolic alkalosis, hyperreninemia, hyperaldosteronism, normal blood pressure, and other clinical symptoms. As a clinical and genetical heterogeneous disorder, this syndrome can be classified into two clinical variants, antenatal Bartter syndrome and classic Bartter syndrome according to the onset age. Nephrocalcinosis is common in antenatal Bartter syndrome, but is rare in classic Bartter syndrome. It can also be classified into five genetic subtypes by the underlying mutant gene, all of which are expressed in the tubular epithelial cells of the thick ascending limb of the loop of Henle. Patients with Bartter syndrome type 1, 2 and 4 present at a younger age than classic Bartter syndrome type 3. We have experienced a case of Bartter syndrome with nephrocalcinosis in a 42-year-old woman diagnosed by biochemical and radiologic studies. We had successful response with potassium chloride and spironolactone.

Extended Spectrum β-lactamase–producing E. coli-related Nosocomial Peritonitis Treated Successfully with Meropenem in a Patient on Peritoneal Dialysis
Seong Kyu Jeong, Yeong Hee Ham, Jin Hyuk Jo, Yeong Sin Sin, Dong Heo, Hark Rim
Kosin Med J. 2013;28(1):43-47.   Published online January 19, 2013
DOI: https://doi.org/10.7180/kmj.2013.28.1.43
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Abstract PDFPubReader   ePub   

Peritonitis is a common and potentially serious infection in patients undergoing continuous ambulatory peritoneal dialysis (CAPD). The most common organisms usually associated with CAPD peritonitis are Staphylococcus aureus and Staphylococcus epidermidis. Rarely, aerobic gram negative bacilli have been the causative agents of CAPD peritonitis. The treatment of CAPD peritonitis requires removal of the peritoneal catheter and treatment with parenteral antibiotics active against the causative pathogen. While hospitalized for CAPD peritonitis, a 55-year-old man on CAPD had nosocomial peritonitis secondary to infection by ESBL–producing E. coli, that was sensitive to imipenem and meropenem. He was treated successfully with a 4-week course of intraperitoneal meropenem therapy without subsequent relapse, loss of peritoneal catheter, ultrafiltration failure, or dialysis inadequacy.

A Case of Invasive Aspergillosis of the Paranasal Sinuses Treated with Surgery and Voriconazole after Kidney Transplantation
Ho Sik Shin, Sin Jun Lee, Yeon Soon Jung, Hark Rim
Kosin Med J. 2011;26(2):183-189.   Published online December 1, 2011
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Related Factors of Depression in Patients with Peritoneal Dialysis
Jeong Rim Lee, Byeng Chul Yu, Hark Rim, Yong Hwan Lee
Kosin Med J. 2010;25(2):65-71.   Published online December 31, 2010
  • 341 View
  • 1 Download
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Glomerular Filtration Rate by Cystatin C-Based Prediction Equations Compared with Serum Creatinine Based GFR in Healthy Young Korean Men
Ho Sik Shin, Yeon Soon Jung, Hark Rim
Kosin Med J. 2009;24(2):20-26.   Published online December 31, 2009
  • 326 View
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Unusual Presentation of Acute Abdomen in Hemorrhagic Fever with Renal Syndrome: A Report of One Case
Ho Sik Shin, Yeon Soon Jung, Hark Rim
Kosin Med J. 2009;24(2):199-202.   Published online December 31, 2009
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A Case of Pelvic Congestion syndrome Mimicking Acute Pyelonephritis
Ja Young Kim, Bong Jin Kim, Chang Sub Lim, Jung Bum Hong, Won Huk Choi, Jin Hur, Dong Hur, Hark Rim
Kosin Med J. 2009;24(2):242-246.   Published online December 31, 2009
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A Case of Severe Renal Osteodystrophy with Pathologic Fractures of Vertebra
Song Ju Lee, Eun Mi Lee, Hark Rim, Yeon Soon Jung, Jae Ho Jang
Kosin Med J. 2008;23(4):234-238.   Published online December 31, 2008
  • 359 View
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A Case of Ureteral Obstruction and Pyonephrosis after Extracorporeal Shock Wave Lithotripsy in 5 Years
Hyun Seung Lee, Kyun Hong Kwon, Yong Gun Jo, Bong Jin Kim, Chang Sup Lim, Ja Young Kim, Dong Heo, Hark Rim
Kosin Med J. 2008;23(4):261-263.   Published online December 31, 2008
  • 205 View
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Remission of Nephrotic Syndrome by the Combination of Low-dose Cyclosporine-A with Diltiazem
Sung Eun Kim, Yeon Soon Jung, Hark Rim
Kosin Med J. 2008;23(3):22-26.   Published online September 30, 2008
  • 379 View
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A Case of Idiopathic Hypoparathyroidism Associated with Striatopallidodentate Calcinosis and Intention Tremor
Sung Jin Kang, Min Jeong Kim, Hark Rim
Kosin Med J. 2008;23(2):103-105.   Published online June 30, 2008
  • 254 View
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Acute Renal Failure induced by Amanita phalloides Poisoning : A Case Report
Hark Rim
Kosin Med J. 2007;22(1):275-278.   Published online June 30, 2007
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A Case of Urinothorax in a Patient with Uterine Cervical Cancer
Hark Rim
Kosin Med J. 2007;22(1):283-286.   Published online June 30, 2007
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Gastric Volvulus as a Complication of a Left Superior Pulmonary Lobectomy
Sang Ryul Chung, Tae In Ha, Seung Soo Moon, Eun A Lee, Soo Hyoung Lee, Byung Do Chai, Young Sik Choi, Hark Rim
Kosin Med J. 2006;21(2):175-179.
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The interdialytic weight gain as a nutritional parameter in hemodialysis patients
Ho Sik Shin, Yeon Soon Jung, Hark Rim
Kosin Med J. 2006;21(1):126-133.
  • 302 View
  • 1 Download
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Mechanism of Reduced Bicarbonate Reabsorption in Cadmium-Intoxicated Rat Kidneys
Young Gi Gil, Hark Rim, Do Whan Ahn
Kosin Med J. 2005;20(1):6-15.
  • 281 View
  • 1 Download
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A Case of Emphysematous Pyelonephritis Associated with Acute Renal Failure : An Experience of Successful Management by Medical Treatment
Hyae Ju Oh, Jae Seong Ryu, Young Il Kwon, Hyoun Jin Sim, Dong Heo, Hark Rim
Kosin Med J. 2003;18(1):152-156.
  • 282 View
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A Case of Rhabdomyolysis associated with Cerivastatin and Cyclosporine Combination Therapy in a Kidney Transplant Recipient
Seong Hoon Shin, Min Dae Kim, Seung Su Kang, Chan Ook Kim, Jee Young Lee, Jae Sup Eum, Kil Su Kim, Sung Il Kweon, Yeon Soon Jung, Hark Rim
Kosin Med J. 2002;17(1):137-141.
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Two Cases of Listeria monocytogenes Meningitis during Immunosuppressant Therapy
Hark Rim, Su Yul Ahn, Kyung Mu Yoo
The Journal of Kosin Medical College. 1994;10(1):59-62.
  • 448 View
  • 1 Download
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