- Satellite cell distribution in the medial rectus muscle in cadavers
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Chang Zoo Kim, Sang Joon Lee
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Kosin Med J. 2024;39(3):195-200. Published online September 10, 2024
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DOI: https://doi.org/10.7180/kmj.24.124
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 Abstract
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- Background
This study aimed to elucidate the potential usefulness of the medial rectus muscle of cadavers for research on satellite cells.
Methods
Twenty-four medial rectus muscles were obtained from 12 cadavers. The control group included six medial rectus muscles from three live adults without brain activity. The muscle fiber diameter and distribution of satellite cells were measured and compared. Immunohistochemistry for myosin heavy chain and the transcription factor PAX7 was performed, and the distributions of myocytes and satellite cells were evaluated.
Results
The average muscle fiber diameter was 142.18±36.49 μm in the cadaver group and 149.34±15.26 μm in the control group, and there was no significant difference between the two groups (p=0.38). The ratio of PAX7(+) cells to the number of muscle fibers was 0.056±0.015 in the control group and 0.006±0.006 in the cadaver group, reflecting a significant difference (p<0.05).
Conclusions
The medial rectus muscles of cadavers can be helpful in studying anatomical morphology; however, their usefulness in muscle satellite cell research appears to be limited.
- Correlation between nasal mucosal thickness around the lacrimal sac fossa and surgical outcomes in endonasal dacryocystorhinostomy
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Jae Ho Yoo, Chang Zoo Kim, Ki Yup Nam, Seung Uk Lee, Jae Ho Lee, Sang Joon Lee
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Kosin Med J. 2018;33(3):358-368. Published online December 31, 2018
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DOI: https://doi.org/10.7180/kmj.2018.33.3.358
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Abstract
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Objectives
To identify the relationship between surgical success rate and preoperative nasal mucosal thickness around the lacrimal sac fossa, as measured using computed tomography.
Methods
We reviewed 33 eyes from 27 patients who underwent endoscopic dacryocystorhinostomy after diagnosis of primary nasolacrimal duct obstruction and who were followed-up with for at least six months between 2011 and 2014. We measured preoperative nasal mucosal thickness around the bony lacrimal sac fossa using computed tomography and analyzed patient measurements after classifying them into three groups: the successfully operated group, the failed operation group, and the non-operated group.
Results
Surgery failed in six of the 33 eyes because of a granuloma at the osteotomy site and synechial formation of the nasal mucosa. The failed-surgery group showed a clinically significantly greater decrease in nasal mucosal thickness at the rearward lacrimal sac fossa compared with the successful-surgery group. However, nasal mucosal thickness of fellow eyes (i.e., non-operated eyes) was not significantly different between the two groups, and the location of the uncinate process did not appear to influence mucosal thickness. In the failed group, posteriorly located mucosal thickness of operated eye fossa was thinner than that of the non-operated eyes, but not significantly so.
Conclusions
Our results from this quantitative anatomical study suggest that nasal mucosal thickness is a predictor of endoscopic dacryocystorhinostomy results.
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Citations
Citations to this article as recorded by  - Post-operative Clinical Evaluation of Endoscopic Dacryocystorhinostomy: Insights from a Three-Month Follow-Up Study
Josiah Irma, Michael Lekatompessy, Arief S. Kartasasmita, Angga Kartiwa, Irawati Irfani, Saraswati Anindita Rizki, Giovanni Adrian Santoso, Jonathan Salim, Veli Sungono, Serena Onasis
Indian Journal of Otolaryngology and Head & Neck Surgery.2024; 76(5): 4208. CrossRef
- Clinical applications and advancements in noninvasive prenatal diagnosis
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Sul Lee, Jin Hyuk Choi, Jong Hyouk Yun, Su Hwan Kang, Jesang Yu, Jihun Kang, Chang Zoo Kim, Taek Yong Ko, Hanggoo Yun
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Received May 26, 2025 Accepted June 16, 2025 Published online June 23, 2025
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DOI: https://doi.org/10.7180/kmj.25.118
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Abstract
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- Noninvasive prenatal testing (NIPT) is widely performed and enables the detection of fetal chromosomal abnormalities through the analysis of cell-free fetal DNA in maternal blood. Since its introduction in 2011, NIPT has demonstrated high sensitivity and specificity for common trisomies (trisomy 21, trisomy 18, trisomy 13), and its scope has rapidly expanded to include sex chromosome aneuploidies, microdeletion syndromes, and single-gene disorders. However, the widespread adoption of NIPT has brought new challenges, including technical limitations (e.g., low fetal fraction, placental mosaicism), interpretation of variants of uncertain significance, and ethical concerns related to over-screening and patient anxiety. This review summarizes the historical evolution, technical advances, clinical applications, limitations, and future perspectives of NIPT, emphasizing the need for balanced clinical implementation and ongoing innovation.
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KOSIN UNIVERSITY COLLEGE OF MEDICINE
